(1) In dogs, H1-receptor stimulation with 2-MeH induced pulmonary vasoconstriction, and a decrease in cardiac output.
(2) Assays were optimized for time, pH, and temperature, using trans-stilbene oxide (TSO) and cis-stilbene oxide (CSO) as substrates for cEH and mEH, respectively.
(3) PGE1, PGF2alpha and 4-methylhistamine (4-MeH: a relatively specific H2-receptor agonist) contract pulmonary arterial strips but further increase in the dose of PGE1 produces relaxation.
(4) Gathering fasting and TPN data MEH excretion was significantly related to both body (r = 0.89) and muscle (r = 0.73) NB, that were highly related to each other (r = 0.93), being muscle always worse than body NB.
(5) The reaction from Wall Street traders is more often along the lines of "meh".
(6) Thus, the hypothalamus-pituitary-adrenal axis is involved in the regulation of mEH but the regulation of the cEH enzyme remains unclear.
(7) In microsomal fractions, enzyme activities measured were pentoxyresorufin O-dealkylase (PROD), ethoxyresorufin O-dealkylase (EROD), and epoxide hydrolase (mEH).
(8) Using benzo[alpha]pyrene-4,5-oxide as substrate, mEH enzymatic activity is shown to correlate closely with tissue levels of mEH mRNA.
(9) The study demonstrates that the balance between activation of CBZ by the cytochrome P450 enzymes to a chemically reactive arene oxide metabolite and its detoxification by mEH and GSH may contribute to individual susceptibility to CBZ idiosyncratic toxicity.
(10) Thus, the pituitary appears to be important in the developmental induction of mEH but not cEH.
(11) 'Hermless, hermless, there's never nae bather fae me, I go to the library, I tak oot a book, and then I go hame for meh tea.'"
(12) Immunoblot analyses revealed that hepatic mEH levels in males increased in an age-dependent manner, with a maximal increase (approximately 3-fold) being noted at 44 weeks of age, whereas the expression of hepatic mEH in females decreased significantly at 14 weeks of age or older, by approximately 70%s, compared with that of 4-week-old rats.
(13) The possible role of the secretion from the Mehlis' gland in egg-shell formation is discussed.
(14) The excretion of the amino acid 3-methylhistidine (3-MeH), an indicator of muscle protein breakdown, and urea nitrogen loss were measured in the urine collected the day before, and on the 2nd and 4th postoperative days.
(15) Urinary excretion of urea nitrogen and 3-methylhistidine (3-MeH) after surgery was significantly lower in the warmed group compared with the cold group (P less than 0.05).
(16) These results provide evidence that the imidazole antimycotic agents induce mEH and that the mEH induction involves large increases in mRNA, with transcriptional activation.
(17) Morphological studies revealed the following major characteristics for 35 day-old worms: the mean length of the terminal segment accounted for 54% of the total worm length; the position of the sexually mature segment was always terminal; the female reproductive system possessed an elongated ovary with compact lobules; the female ducts were also compact; the Mehlis' gland was covered by the vitelline gland and the testes were distributed throughout the segment, with 1 row posterior to the vitelline gland.
(18) We have assessed the effects of glutamine (Gln) availability on protein breakdown in perfused rat hindlimb by measuring net phenylalanine (Phe) production (an index of protein balance), the dilution of [15N]Phe labelling (an index of mixed protein breakdown) and rate of production of 3-methylhistidine (3-MeH) (an index of myofibrillar breakdown).
(19) Clotrimazole, however, maintained the activated mEH transcription rate at 24 hr after treatment, exhibiting a 11-fold increase, compared with control.
(20) Immunoblot analyses revealed that administration of either ketoconazole or clotrimazole caused a approximately 4-5-fold increase in mEH levels, whereas either miconazole or econazole resulted in a approximately 7-fold increase in mEH at day 3 after treatment.
Unexceptional
Definition:
Example Sentences:
(1) The unexceptional validity of the autosomal-recessive hereditary transmission may be confirmed.
(2) The house she walks back to, and in which she and her husband, Geoff, live, is pleasantly unexceptional.
(3) In the present study the iron-founding town of Kirkintilloch was found to have standardised mortality ratios (SMRs) for respiratory cancer in 1959-63, 1964-8, and 1969-73 that were unexceptional in comparison with Scotland.
(4) We perceive the circumstances of our youth as normal and unexceptional, however sparse or cruel they may be.
(5) These compounds also proved to be unexceptional in their inhibition of LAP (17-O-, Ki = 56 microM; 17-NH2, Ki = 40 microM).
(6) Substrates with sequences related to the cathepsin G cleavage site in angiotensin I and angiotensinogen, and the reactive site of alpha 1-antichymotrypsin, were hydrolyzed effectively by enzyme, but with unexceptional rates.
(7) It is this part of the operation which registars find most difficult and why we suggested (June 30, p. 773) a different site for insertion in the unexceptional case.
(8) Labour spending increased considerably, but until the crash was still "unexceptional", either by historic UK standards or international ones.
(9) How a 'moment of anger' led to tragic death of Bailey Gwynne Read more Lowe, who also had to establish the relationship between Bailey and his killer prior to the stabbing, concluded that their altercation had been “an unplanned, spontaneous conflict that emerged rapidly out of an unexceptional banter.
(10) It is suggested that these results were unexceptional, except possibly for the failure of the plasma cholesterol concentration to rise when cholesterol was ingested, despite gross differences in diet and many other factors.
(11) The means for all groups were unexceptional, but some of the differences were significant.
(12) The junction region comprises one base pair and the two neighboring internucleotide linkages and exhibits full hydrogen-bonded base-pairing, full base-stacking, and unexceptional stereochemistry.
(13) 5) They had fear of fatness almost unexceptionally.
(14) Three arguments are presented: a) that Darwin, qua scientist, was only interested in species adaptation, an entirely different concept from that of individual adaptation, b) that Darwin's writings on individual adaptation are so unexceptional that it is inconceivable that psychologists should have been influenced by them and c) that the two concepts are logically incompatible since species adaptation presupposes a strict hereditary determinism, while individual adaptation conceives of the organism either as free and undetermined or else as determined by the environment.
(15) The amino acid composition is unexceptional, and no evidence for hexosamine has been obtained.
(16) The testicular involvement was unexceptionally bilateral with occasional differences in the grade of infiltration, slight to moderate.
(17) Williams insisted the information Mulcaire held was commonly used by the media and unexceptional.
(18) Before that, his teenage band the Jades had released two entirely unexceptional doo-wop tracks in 1958 and two years later he had chanced his arm as a solo singer, recording in the perky, post-rock'n'roll style that predominated in pre-Beatles America.
(19) Calais camp: fires sweep settlement as refugees leave – in pictures Read more Describing the tragedy as an unexceptional day at sea, MSF called on the EU to provide safe alternative routes rather than focusing on deterrence.
(20) Rate constants for the other reactions are unexceptional.