(n.) A kind of mental unsoundness characterized by extreme depression of spirits, ill-grounded fears, delusions, and brooding over one particular subject or train of ideas.
Example Sentences:
(1) The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin.
(2) The patients were categorized according to DSM-III as suffering from either minor depression (including dysthymic disorder, 300.40; adjustment disorder with depressed mood, 309.00; atypical depression, 296.82) or major depression (without melancholia, 296.X2; with melancholia, 296.X3; with psychotic features, 296.X4).
(3) Von Trier, who took a " vow of silence " after being banned from the Cannes film festival in 2011 after joking about Nazism during a press conference for Melancholia, arrived at Nymphomaniac's photocall wearing a T-shirt emblazoned with the phrase "Persona Non Grata"; true to his word, he failed to attend the subsequent press conference where his actors and producer talked about the film.
(4) This study reports an open clinical trial in which seven of eight outpatients (88%) with melancholia responded to phenelzine treatment.
(5) Speaking at a press conference following the preview of his latest film, Melancholia, von Trier expressed sympathy for Hitler, remarked that Israel was "a pain in the arse" and jokingly confessed to being a Nazi .
(6) With the Extracted Criteria, initial insomnia, early waking, anorexia, weight loss, loss of libido, and worsened mood in the morning were all significantly more common in melancholia than in non-melancholic depression, while increased appetite was more common in non-melancholia.
(7) The first, or maybe, occurrence of the word "melancholia" is found in a French mediaeval book "Knight Yvain" (12th century).
(8) Patients with endogenous depression (melancholia) as defined by each of ICD-9, DSM-III, RDC and Newcastle scale demonstrated a reduced prolactin response to 60 mg oral fenfluramine when compared with non-endogenous subjects.
(9) We performed the DST in 95 depressed inpatients to determine whether abnormal DST results were associated with individual symptoms of depression, latent behavioral "factors," melancholia, or severity of depression.
(10) Neurotic subtyping was significantly negatively associated with DSM-III melancholia.
(11) In this study an evaluation of the inter-rater reliability of the Hamilton Depression Rating Scale, the Melancholia Scale and the Montgomery-Asberg Depression Rating Scale has been carried out.
(12) We also studied a group of depressed patients without melancholia (n = 11) with mean age 65.2 years, and found a similar, but less pronounced, alteration of the FVER.
(13) The Danish director was thrown out of the festival for dim comments made about Hitler at the press conference after his film Melancholia , although the film itself bizarrely remains in with a chance of prizes tonight, with its star Kirsten Dunst having particularly impressed Robert De Niro and his jury, I hear.
(14) This kind of acting is in fact also observed in melancholia, psychoses and prepsychotic states, depressions with jealousy, borderlines and the actors of "accompanied suicides".
(15) Non-suppression was found in most of the diagnostic categories, but there was a highly significant association with the DSM-III classification 'major depressive episode with melancholia' (52%) in comparison with the ICD group 'manic-depressive illness-depressed' (29%).
(16) The DST may be useful as an adjunct to the diagnostic and monitoring process in primary depression with melancholia.
(17) In psychiatry cocaine was used--also on Freud's recommendation--as an euphoriant excitant in cases of melancholia, both physical and psychic exhaustion and of cachexia.
(18) Our findings support the descriptive validity of the DSM-III melancholia diagnostic category, although the DSM-III criteria are too conservative and include nonrelevant symptoms (e.g., diurnal variation, anorexia-weight loss) whilst excluding some important items (e.g., loss of energy, cognitive disorders).
(19) The thyrotropin (TSH) and prolactin (PRL) responses to TRH were studied in 15 female depressed patients with melancholia (nine unipolar, six bipolar) during an electroconvulsive therapeutic course.
(20) Non-suppression of cortisol after dexamethasone was associated with blunted TSH-responses only in melancholia.
Melancholic
Definition:
(a.) Given to melancholy; depressed; melancholy; dejected; unhappy.
(n.) One affected with a gloomy state of mind.
(n.) A gloomy state of mind; melancholy.
Example Sentences:
(1) The authors took multiple serum samples for measurement of melatonin between 4:30 p.m. and 7:30 a.m. in seven male depressed patients with melancholia and five healthy male control subjects and found that melancholic patients had a significantly lower rise of melatonin.
(2) With the Extracted Criteria, initial insomnia, early waking, anorexia, weight loss, loss of libido, and worsened mood in the morning were all significantly more common in melancholia than in non-melancholic depression, while increased appetite was more common in non-melancholia.
(3) Patients with a past history of major melancholic depression or severe agoraphobia had similar binding parameters as panic disorder patients without a history of depression or severe agoraphobia.
(4) Every episode was diagnosed cross-sectionally as schizophrenic, melancholic, manic, manic-depressive mixed, schizodepressive, schizomanic or schizomanic-depressive mixed.
(5) Lower fT3 levels were also observed in melancholic depressed patients when compared with nonmelancholic depressed patients or when compared with normal control subjects.
(6) Melancholic episode: according to "Major Depression, Melancholic Type" of DSM-III-R. Manic episode: according to the criteria of DSM-III, slightly modified.
(7) Controlling for baseline biological, clinical, and demographic factors eliminated the higher prolactin response in the melancholic and psychotic patients, attenuated the blunted GH response in the unipolar patients, and revealed a blunted GH response in the melancholic patients.
(8) Occasionally certain behavioural styles and symptoms can be seen in melancholics which are difficult to classify as hysterical or pseudohysterical.
(9) However, when subjects were stratified based upon the presence or absence of DSM III-R melancholic features, the melancholic depressives showed little change in weekly depression ratings compared to patients without melancholic symptoms (p less than 0.001).
(10) Sixty-four percent of buspirone patients and 50% of placebo patients were melancholic; 64% of buspirone patients and 74% of placebo patients discontinued treatment before the end of the study.
(11) To explore whether abnormal CCK secretion during feeding may be related to pathophysiological mechanisms in disorders associated with appetite abnormalities, we report here studies of the plasma CCK response to a test meal in patients with bulimia nervosa, as well as seasonal (hyperphagic) and melancholic (anorexic) depression.
(12) A tendency in the opposite direction of the thyroxine values was found in bipolar (melancholic) patients.
(13) The results suggest that the 'depressive attributional style' may be specific to melancholic patients, and underline the importance of studying well-defined diagnostic subgroups.
(14) The test may have power in differentiating severe melancholic depression, mania, or acute psychosis from chronic psychosis (87% specificity) or dysthymia (77% specificity).
(15) In addition, when patients with more severe, melancholic, subtype of depression were examined, adinazolam was also as effective as imipramine.
(16) In the depressed group, irritability and DSM-III-R melancholic type predicted 40% or the variance of stage 4 increment after ritanserin, as assessed by stepwise multiple regression.
(17) In conditions of conflict between probability and value of reinforcement the dogs manifested two opposite strategies of behaviour: orientation to highly probable events (choleric and phlegmatic) and to low-probable events (sanguinic and melancholic) what is connected with individual properties of functioning and the character of interaction of four brain structures (frontal cortex, hippocampus, hypothalamus, amygdala).
(18) The sensitivity of the DST (rate of a positive outcome, or nonsuppression of cortisol) in major depression is modest (about 40%-50%) but is higher (about 60%-70%) in very severe, especially psychotic, affective disorders, including major depression with psychotic as well as melancholic features, mania, and schizoaffective disorder.
(19) Serotonin in platelet-free plasma and in platelets from melancholics was significantly reduced to 30% and 60% of their respective control values.
(20) Many wept, wiping tears off their faces as the melancholic tunes of the hymns reached them through loudspeakers.