(n.) Depression of spirits; a gloomy state continuing a considerable time; deep dejection; gloominess.
(n.) Great and continued depression of spirits, amounting to mental unsoundness; melancholia.
(n.) Pensive maditation; serious thoughtfulness.
(n.) Ill nature.
(a.) Depressed in spirits; dejected; gloomy dismal.
(a.) Producing great evil and grief; causing dejection; calamitous; afflictive; as, a melancholy event.
(a.) Somewhat deranged in mind; having the jugment impaired.
(a.) Favorable to meditation; somber.
Example Sentences:
(1) One radio critic described Jacobs' late night Sunday show as a "tidying-up time, a time for wistfulness, melancholy, a recognition that there were once great things and great feelings in this world.
(2) And melancholy is not the only thing that links Haigh’s work.
(3) Melancholy originally had another meaning from the present one.
(4) the agitated type of involutional melancholy occurred twice as often in Canada as in Hungary, the apathetic cases were rarer in Canada, and the illness began earlier among Canadian women.
(5) Thus New Zealand, like other countries, may be entering an age of melancholy.
(6) English explanations stressed religious aspects and a relationship to melancholy.
(7) I too was attracted to the paintings of De Chirico and Delvaux, with their dreamplaces – empty, melancholy cities, abandoned temples, broken statues, shadows, exaggerated perspectives.
(8) Earlier this week in Janesville, where post-industrial melancholy is evident in a closed car plant and eerily quiet downtown, House speaker Paul Ryan crushed a Trump-style challenger in a congressional primary.
(9) There was always a rueful melancholy, stiffened by irony and leavened by humour about him.
(10) Song of the summer was Waterloo Sunset by the Kinks, with its odd blend of keening melancholy and positivism.
(11) Resorting to a series of Ted the swordsman scenes which may merely be the lurid fantasies of the heroine, director Christine Jeffs never makes it clear whether Hughes was a rampaging philanderer whose sexual conquests and general obliviousness to Plath's mounting depression led to her demise, or a man driven into other women's arms by his wife's chronic melancholy - perhaps the most time-honoured excuse of the inveterate tomcat - or both.
(12) "Oh, if one of Dostoevsky's novels, whose black melancholy is regarded with such indulgent admiration, were signed with the name of Goncourt, what a slating it would get all along the line."
(13) It's a melancholy fate for any writer to become an eponym for all that he despised, but that is what happened to George Orwell, whose memory is routinely abused in unthinking uses of the adjective "Orwellian".
(14) As the lead singer with the Walker Brothers, he enjoyed a number of melancholy hits with songs such as The Sun Ain't Gonna Shine Anymore, My Ship Is Coming In, No Regrets.
(15) The leading role is infinitely variable: as Oscar Wilde said , "There are as many Hamlets as there are melancholies."
(16) In the right light and with the right song playing on the radio, there is a certain melancholy charm to this bleak highway with its unfolding panorama of wind turbines and electricity pylons stretching to the horizon.
(17) On the contrary: Sørens incomparable melancholy, mental agony and anxiety (fear or anguish) forced the faith, existing independently of them, in a radical refining.
(18) There’s a magnificent melancholy about him, this shadowy figure performing an act of unrequited love.
(19) Closer is a melancholy piece but it is also laugh-out-loud funny, often, as in the very best drama, at moments of starkest pain.
(20) Research is needed to determine whether youth will be predisposed to further depressive episodes and, if so, will we be entering a new age of melancholy?
Pule
Definition:
(v. i.) To cry like a chicken.
(v. i.) To whimper; to whine, as a complaining child.
Example Sentences:
(1) The previously uncharacterized third and fourth genes (pulE and pulF) of the pullulanase secretion gene operon of Klebsiella oxytoca strain UNF5023 are, respectively, predicted to encode a 55 kDa polypeptide with a putative nucleotide-binding site, and a highly hydrophobic 44 kDa polypeptide that probably spans the cytoplasmic membrane several times.
(2) Under basal conditions oral penbutolol induced a decrease of pule rate and blood pressure but no change in plasma or urinary catecholamines.
(3) This suppression was due to increased [K+]0 and not to K-induced depolarization because it persisted when membrane potential was held by means of a conditioning hyperpolarizing puled gradually after maximum repolarization.
(4) 25 laryngeal carcinomas were investigated by pules cytophotometry, stained with ethidium bromide after pepsination.
(5) These results are in line with the predicted absence from PulE of a region of sufficient hydrophobicity to function as a signal sequence.
(6) Expression of pulE in minicells or under the control of a strong bacteriophage T7 promoter resulted in the production of a c. 58 kDa cytoplasmic protein.
(7) Gene disruption experiments indicated that both pulE and pulF are required for pullulanase secretion in Escherichia coli K-12.
(8) A representative PulE-beta-galactosidase hybrid protein created by Tnlac mutagenesis was also found mainly in the cytoplasm.
(9) These include the P. aeruginosa PilB protein, the ComG ORF-1 protein from the Bacillus subtilis comG operon (necessary for competence), the PulE protein from the Klebsiella oxytoca (formerly K. pneumoniae) pulC-O operon (involved in pullulanase export), and the VirB-11 protein from the virB operon (involved in virulence) which is located on the Agrobacterium tumefaciens Ti plasmid.
(10) They issue great puling statements about income imbalance in a game that pays them $100m per annum just for the act of being able to cash checks and maybe pay attention long enough to run a franchise into the ground.
(11) In addition, PulE protein has consensus sequences found in a wide variety of nucleotide-binding proteins.
(12) The deduced amino acid sequence of ORF1 is related to the Klebsiella pneumoniae PulE protein, to the Bacillus subtilis ComG ORF1 and to the Agrobacterium tumefaciens VirB ORF11 products.