(n.) Any one of series of compounds, hydrosulphides of alcohol radicals, in composition resembling the alcohols, but containing sulphur in place of oxygen, and hence called also the sulphur alcohols. In general, they are colorless liquids having a strong, repulsive, garlic odor. The name is specifically applied to ethyl mercaptan, C2H5SH. So called from its avidity for mercury, and other metals.
Example Sentences:
(1) Sodium dodecyl sulfate-polyacrylamide gel analyses of these cross-linked nuclear receptor complexes labeled with the covalently attaching ligand [3H]tamoxifen aziridine reveal a species of about 130,000 mol wt, while the noncross-linked or the cross-linked but mercaptan-cleaved receptor is 65,000 mol wt.
(2) Linear distortion of the mercaptan (polysulfide) rubber base that takes place during setting is a cause of this problem.
(3) Three dialysis membranes, including a polyacrilonitrile membrane, a polycarbonate membrane and a cuprophan membrane coated with charcoal, have been compared with cuprophan in order to assess their ability to clear from aqueous solution and plasma, substances thought to be of pathogenetic importance in hepatic coma (ammonia, short chain fatty acids and mercaptans), some protein bound (glycocholate and bromsulphthalein) and some middle molecular weight molecules (ethylenediaminetetracetic acid, cyanocobalamin and inulin).
(4) A single and chronic inhalation exposure to a complex of chemical substances being part of hydrogen sulphide-containing natural gas (hydrogen sulphide, hydrocarbon, mercaptan, sulphur dioxide) results in a decline in humoral indicators of non-specific body resistance.
(5) A series of alkylthiocolchcines (methyl, ethyl, n-butyl, n-hexy, n-octyl, and pinanyl) was prepared from colchicine by treatment with the appropriate alkyl mercaptan and p-toluenesulfonic acid.
(6) Varieties of thioalkyl-containing quinone and hydroquinone analogues of quinocarcin (1a) were prepared effectively, by addition of mercaptan to 3a-c, which were derived from 1a via DX-52-1 (1b).
(7) Nine of these compounds, hydrogen sulfide, methyl mercaptan, dimethyl sulfide, dimethyl disulfide, methyl acetate, ethyl acetate, heptadiene, methanol, and ethanol, were found on chicken spoiled at both 2 and 10 degrees C. xylene, benzaldehyde, and 2,3-dithiahexane were detected only in samples stored at 2 degrees C and methyl thiolacetate, 2-butanone, and ethyl propionate were associated with 10 degrees C spoilage.
(8) Silicone and polyether materials exhibited perceptibly less permanent deformation than mercaptan materials ten minutes after mixing.
(9) Nucleophilic opening of the chiral epoxide with dodecyl mercaptan gave optically active 1-S-dodecyl-3-O-trityl-1-thio-glycerol, which was used to synthesize 1-S-dodecyl-2-O-decanoyl-thio-sn-glycero-3-phosphocholine.
(10) To induce increased tissue levels of ammonia, mercaptans and fatty acids which are found in HE due to FHF, carefully predetermined doses of urease, dimethyldisulphide and octanoic acid were administered.
(11) The structures of mercaptan and sodium borohydride reaction products of neocarzinostatin chromophore A (NCS Chrom A) are compared.
(12) Metabolic ethyl mercaptan is sufficiently bound to be undetectable by the methods used without hydrolysis.
(13) This system has been shown to be capable of catalyzing the desired reactions with endogenous toxins such as phenols and mercaptans in vitro, and phenols in rabbits in vivo.
(14) P-site cross-linking was more sensitive to mercaptan quenching (50% at 0.5 mM) than was that at the A site (50% at greater than 2.0 mM) but both were partially shielded from solvent.
(15) The drug, only under acidic conditions, reacted with a stoichiometric amount of ethyl mercaptan (or beta-mercaptoethanol) to produce regio-isomers of N-sulfenylated omeprazole sulfide (5-methoxy-2[[(4-methoxy-3,5- dimethyl-2-pyridinyl)methyl]thio]-1- or 3-(ethylthio)benzimidazole).
(16) from L-methionine, the production of large amounts of both dimethyl disulfide and methyl mercaptan was found to be a characteristic of the genus.
(17) The hemolytic action of commercially available nonionic surfactants and synthesized polyoxyethylene fatty acids and mercaptans on human erythrocytes was measured.
(18) Running of gas-cylinder buses (GCB) fueled with liquefied propane-butane mixture added with ethyl mercaptan odorant leads to undesirable medical and social consequences.
(19) 2-hydroxyethyl-mercaptan an ingredient used in mammalian cell culture, inhibited antibody production in trout cells.
(20) 2-Cyano-6-alkylthio- and 6-phenylthiopyrazines were prepared from 2-cyano-6-chloropyrazine (CCP) in the reaction with mercaptans.
Thiol
Definition:
Example Sentences:
(1) Conversion of the active-site thiol to thiocyanate makes it more difficult to inactivate the enzyme by treatment with Cd2+.
(2) Loss of reduced protein thiols, as measured by binding of the thiol reagent iodoacetic acid to GPD, and loss of GPD enzymatic activity occurred in a dose-dependent manner.
(3) The synthetic S-nitroso-thiol, S-nitroso-N-acetylcysteine, markedly inhibited platelet aggregation with an IC50 of 6 nM.
(4) Based on incorporation of radioactively labeled N-ethylmaleimide, the readily reactive thiol groups of isolated myosin (EC 3.6.1.3) from fast, slow and cardiac muscles could be classified into 3 types.
(5) The enzyme was inhibited by thiol and carbonyl reagents.
(6) The thiol-conjugating capacity of quinones may, however, be applied to reduce the tissue-damaging effects of stimulated neutrophils.
(7) In vitro inhibition of the heme-containing enzyme delta-aminolevulinic acid dehydratase by ATG was reversible in the presence of physiological concentrations of small thiols.
(8) The reactivity of the three disulphide bridges of insulin towards sodium sulphite was studied by amperometric titration of the liberated thiol groups.
(9) Heterogeneity in thiol content of sperm within individual samples was also observed.
(10) Both benzyl alcohol dehydrogenase and benzaldehyde dehydrogenase II were inhibited by the thiol-blocking reagents iodoacetate, iodoacetamide, 4-chloromercuribenzoate and N-ethylmaleimide.
(11) In the normal lens, we found nearly 10% of the total nonprotein thiols bound to the protein.
(12) The choice of 400 nm to monitor the reaction excludes the interference of other intermediates in the reaction of ebselen with thiols as well as the reaction of the thiols with CDNB.
(13) The sulfhydryl enzyme malate synthase was inactivated by X-irradiation in air-saturated aqueous solution, in the absence or presence of a variety of additives (thiols, antioxienzymes, typical radical scavengers, inorganic salts, buffer components, substrates, products, analogues).
(14) Based on the iodoacetamide inactivation and disulfide protection of thioltransferase activity, a model for the catalytic mechanism of the thiol-disulfide oxidoreduction is proposed.
(15) These results suggested that in isolated adipocytes: there are high-affinity and low-affinity receptors, but the low-affinity receptors are absent at 21 degrees C; the binding of oxytocin can be regulated by insulin, and growth factors; and the oxytocin receptors contain disulfide bridges and free thiols that are essential for the maintenance of oxytocin binding.
(16) Finally, there has been considerable interest in supplying thiols by use of the SH-containing angiotensin converting enzyme inhibitors, such as captopril.
(17) The thiol oxidizing agent diamide inhibited both vaso- and bronchoconstriction induced by H2O2, AA, or U-44069.
(18) IPNS was rapidly inhibited by the thiol-blocking reagents N-ethylmaleimide and 2,2'- and 4,4'-dipyridyl disulphide, but not by 5,5'-dithiobis-(2-nitrobenzoic acid) in the same concentration.
(19) Interaction of Se with SeBP is completely blocked by thiol inhibitors.
(20) Effects on CLE formation, morphology, PA, and ornithine decarboxylase activities, EGF binding, and thiol levels were evaluated using 40% growth inhibitory concentrations.