(n.) The middle segment of the brain; the midbrain. Sometimes abbreviated to mesen. See Brain.
Example Sentences:
(1) 5-HT containing terminals and fibers also were observed in the mesencephalon and appeared to run rostrally in the medial part of the medial forebrain bundle.
(2) Effects of noxious electrical tooth stimulations and intraarterial administration of bradykinin or inhalation of volatile anesthetics on substance P content in the diencephalon-mesencephalon, pons-medulla and the spinal cord were examined in the rat.
(3) In order to study the interactions between serotonergic mechanism and electrical stimulation of the mesencephalic central gray substance, rats were trained to lever-press for terminating aversive electric stimuli applied at the Periaqueductal gray and adjoining tectum of the mesencephalon.
(4) The activity of glycerophosphorylcholine phosphodiesterases was determined in the mesencephalon, diencephalon, cerebral hemispheres, cerebellum and olfactory bulb during postnatal development from P5 to P70 of rat brain.
(5) In addition, these amines caused a concurrent change in the release of ACh at perfusion loci in both thalamus and mesencephalon.
(6) Levels of acetylcholine were significantly elevated in the telencephalon and diencephalon + mesencephalon of rats killed by near-freezing during conditioned suppression of food-reinforced lever pressing, whereas levels of serotonin, dopamine, and norepinephrine were not altered.
(7) The onset of convulsions induced by these convulsants coincides with the fall in GABA content and GAD activity in the mesencephalon area, and in contrast, the cessation of the convulsions by PN supplement coincides with the recovery in both the parameters.
(8) However, a later component of the Cnf-AEP whose generation locus within the mesencephalon is unknown was modulated by bf stimulation.
(9) Six hours after treatment with AOAA the GABA levels in the cerebellum, the cortex, the ventral mesencephalon and the striatum.
(10) Responses of substantia nigra zona compacta neurons to nomifensine and amantadine were studied with intracellular recording techniques (current and voltage clamp) in in vitro slice preparation of rat mesencephalon.
(11) These results describe a novel neurochemical system within the rat basal ganglia that is regulated by dopaminergic innervation from the mesencephalon.
(12) The left vertebral angiography revealed an anteriovenous malformation in the mesencephalon mainly feeded by the thalamoperforate artery and the medial branch of the posterior choroidal artery.
(13) (1) In 27 animals microinjection of 25--100 ng of angiotensin II through chronic cannulae implanted in the preoptic region initiated drinking and in subsequent acute experiments influenced the spontaneous discharge rate of single neurons in the ipsi-lateral mesencephalon.
(14) Into the second week of embryo growth (E7-E15), GABA appears in the mesencephalon (E7) and the eye (E9-E10).
(15) Behavioral augmentation also has been shown with opioids such as morphine, and it is known that a stimulant action on dopaminergic perikarya in the ventromedial mesencephalon is critical to the development of behavioral sensitization to morphine.
(16) Since EKC- and NANM-induced cardiovascular and respiratory depression were not observed in conscious intact or chronic spinal dog, it is suggested that: 1) kappaergic system rostral to mesencephalon may play a role in counteracting these depressant effects of EKC; 2) sigma receptor-mediated tachypnea and tachycardia are dissociable; the tachypneic effect may be mediated through higher center while the medulla oblongata is involved in producing tachycardia.
(17) Critical points of changing axial orientation were identified at the mesencephalon, the Rathke pouch and third branchial arch, and with the hepato-cardio-respiratory complex split between the 2 axes.
(18) The local cerebral blood flow and oxygen tension in the brain cortex, the reticular formation of the mesencephalon and the posterior hypothalamus were studied in chronic experiments in non-anesthetized rabbits with experimentally induced myocardial infarction.
(19) The variation was in the order leptomeninges greater than hypothalamus greater than cerebral cortex = mesencephalon greater than cerebellum = brain stem.
(20) In the present work, using the indirect peroxidase-labelled antibody technique, we made a comparative study about the distribution of Met-enkephalin-like-immunoreactive (ELI)-cell bodies in rat mesencephalon; comparing animals that received colchicine into the lateral ventricle and animals that got the colchicine injected into different cerebral nuclei.
Tegmental
Definition:
(a.) Of or pertaining to a tegument or tegmentum; as, the tegmental layer of the epiblast; the tegmental cells of the taste buds.
Example Sentences:
(1) The effects of clozapine on the spontaneous firing rate of noradrenergic (NE, locus coeruleus), dopaminergic (DA, zona compacta, ventral tegmental area) and non-dopaminergic (zona reticulata) neurons was studied in chloral hydrate anesthetized rats.
(2) Transplants of cell suspension obtained from the locus coeruleus region of 13- to 14-day-old rat fetuses were implanted into the hippocampal formation of intact adult rats or rats from which the noradrenergic afferents to the hippocampus had been removed by bilateral 6-hydroxydopamine (6-OHDA) injections into the dorsal tegmental noradrenergic bundle.
(3) All of these connections are in varying degree bilateral, with decussations in the supramammillary region, ventral tegmental area and median raphe nucleus.
(4) The glutamatergic mechanisms of neostriatum and nucleus accumbens septi play a minor role in attenuation of tegmental self-stimulation with droperidol, fluphenazine, trifluoperazine and clozapine but these mechanisms seem to be responsible for the suppression of "reward" phenomenon with haloperidol, thioridazine and aminazine.
(5) These results suggest that: (1) catecholaminergic (mainly dopaminergic) and prefrontal cortical terminals in the nucleus accumbens septi dually synapse on common spiny neurons; and (2) dopaminergic neurons in the ventral tegmental area receive monosynaptic input from prefrontal cortical afferents.
(6) Marked reductions in DOPAC (35%) and HVA (50%) occurred in the ventral tegmental area between 20 and 32 months of age.
(7) Fewer, but still ample numbers, of SP-reactive axons are present also in the ventral tegmental and retrorubral areas of the midbrain tegmentum and in the ventral pallidum of the basal forebrain, but only sparse ME-reactive axons are present in these areas.
(8) Ventral tegmental area injections of SK effected locomotor hyperactivity, a mesolimbic-mediated behavior.
(9) In the brain stem, dense bundles of the descending fibres were found in the central and the medial tegmental tracts and in the medial longitudinal fasciculus.
(10) The regional changes in glucose utilization induced by U-50,488H in the brain were most pronounced in components of the limbic forebrain circuit such as the anterior thalamic nuclei, mammillary body, frontal cortex, lateral septal nucleus, nucleus accumbens and lateral habenular nucleus as well as in the brainstem tegmental nuclei and the dorsal and median raphe nucleus (components of the limbic midbrain area).
(11) The unitary responses to the gastric vagal and greater splanchnic fibers stimulation were bilaterally distributed in the ventral and dorsal tegmental nuclei.
(12) These include the paraventricular and periventricular hypothalamic nuclei, the linear raphe nucleus, nucleus interfascicularis, and in neurons embedded in the fibres of the dorsal tegmental decussation.
(13) DYN B cell bodies were present in nonpyramidal cells of neo- and allocortices, medium-sized cells of the caudate-putamen, nucleus accumbens, lateral part of the central nucleus of the amygdala, bed nucleus of the stria terminalis, preoptic area, and in sectors of nearly every hypothalamic nucleus and area, medial pretectal area, and nucleus of the optic tract, periaqueductal gray, raphe nuclei, cuneiform nucleus, sagulum, retrorubral nucleus, peripeduncular nucleus, lateral terminal nucleus, pedunculopontine nucleus, mesencephalic trigeminal nucleus, parabigeminal nucleus, dorsal nucleus of the lateral lemniscus, lateral superior olivary nucleus, superior paraolivary nucleus, medial superior olivary nucleus, ventral nucleus of the trapezoid body, lateral dorsal tegmental nucleus, accessory trigeminal nucleus, solitary nucleus, nucleus ambiguus, paratrigeminal nucleus, area postrema, lateral reticular nucleus, and ventrolateral region of the reticular formation.
(14) AHA axons staying ventral projected to the supramammillary region, ventral tegmental area, raphe nuclei and midbrain reticular formation.
(15) Recent lesion studies on young rats suggest that the components of the rodent's general learning system (GLS; a group of brain structures essential for normal acquisition of a wide range of laboratory tasks, include the regions of the caudatoputamen, globus pallidus, ventrolateral thalamus, substantia nigra, ventral tegmental area, superior colliculus, median raphe, and pontine reticular formation).
(16) Retinopetal fibers, originating from bilaterally distributed neurons of the tegmental midbrain, were thin and varicose and ran parallel to the ganglion cell axons to terminate either with a varicose enlargement or a few short sidebranches in the sclerad third of the inner plexiform layer.
(17) In order to determine whether 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) produces neuronal death or the loss of tyrosine hydroxylase (TH) immunoreactivity, 4 catecholaminergic nuclei in the mouse: substantia nigra compacta (SNc), locus coeruleus (LC), ventral tegmental area (VTA) and the A13 nucleus in the hypothalamus were quantitatively examined.
(18) Subsequent experiments employed anaesthetized rats; kainate was microinfused into tegmental sites in order to stimulate local cholinergic perikarya, and concurrently, extracellular recordings were made of single dopaminergic neurons in the substantia nigra.
(19) Short-term haloperidol significantly decreased the concentrations of somatostatin in the caudate-putamen, nucleus accumbens, and ventral tegmental area, and decreased the concentration of substance P in the substantia nigra and the nucleus accumbens.
(20) Neurons of the cholinergic laterodorsal tegmental nucleus were retrogradely labelled after injections into the anterior, laterodorsal, central medial, and mediodorsal nuclei, suggesting that it provides a projection to limbic components of the thalamus.