(1) Local infusion of high concentrations of GABA or GABA mimetics into the striatum, septum or substantia nigra failed to modify 5-HTP accumulation in these areas.
(2) A possible cellular basis for dopaminergic sensitization by long-term dopamine mimetics was examined in rat brain striatum.
(3) Selective beta-mimetic drugs are the most frequently used agents for arresting preterm labour.
(4) The results are interpreted on the basis of the chemical structure and conformations of the ionophores in membrane mimetic media.
(5) We studied a role of TXA2 in the development of PAF-induced nonspecific airway hyperresponsiveness in guinea pigs using a TXA2 synthetase inhibitor (OKY-O46.HCl) and a stable TXA2 mimetic agent (STA2).
(6) In order to confirm these findings, we have studied the effect of GABA mimetics on extracellular DOPAC in the locus coeruleus (a reliable index of noradrenergic neuronal activity) of the rat through the use of in vivo voltammetry with carbon fibre electrodes.
(7) Vanadate possesses insulin-mimetic effects, and has been reported to correct the metabolic imbalances in streptozotocin-induced diabetes.
(8) With regard to the ST-depression, a possible physiological adaptation to the beta-mimetic drug is described.
(9) The novel antibacterial peptide mimetic alaphosphin (l-alanyl-l-1-aminoethylphosphonic acid) selectively inhibited peptidoglycan biosynthesis in both gram-negative and gram-positive bacteria.
(10) Two series of 1,2,4-triazolo[4,3-a]pyrazine derivatives with human renin inhibitory activity have been synthesized which incorporate the transition-state mimetics (3S,4S)- and (3R,4S)-5-cyclohexyl-3,4-diaminopentanoic acid ((S)- and (R)-CDAPA), and (4S)-4-amino-5-cyclohexyl-2,2-difluoro-3-oxopentanoic acid (ACDFOPA).
(11) A novel selective PDE V inhibitor, SK&F 96231, reversed the bronchoconstriction induced in anaesthetised guinea pigs by histamine, a thromboxane-mimetic or by ovalbumin challenge.
(12) The effect of lowering total plasma and low density lipoprotein (LDL) cholesterol in heterozygous familial hypercholesterolaemia type IIa (FH) on platelet function, thromboxane (TX) formation and platelet sensitivity against iloprost, a stable prostacyclin mimetic, was studied in platelet-rich plasma ex vivo.
(13) Blockade of these beta-mimetic effects resulted in a fall in uterine blood flow as the perfusion pressure was reduced.
(14) The majority of the remaining damage could be blocked, in a dose-dependent manner, by superoxide dismutase (SOD) or a SOD-mimetic copper complex, identifying a fraction of damage to intracellular DNA dependent upon extracellular O2-.
(15) Dopamine (DA) and DA-mimetics (apomorphine, midantan, piribedil) have a dual effect on Na, K-ATPase of the rat brain striate synaptosomes: activating at micromolar concentrations and inhibitory at higher concentrations (less than or equal to 30 microM).
(16) The lymphatics were mounted in tissue baths, and isometric contractions were induced by increasing concentrations of the thromboxane A2 (TXA2) mimetic U-46619.
(17) BAY u3405 was a potent, and competitive, antagonist of the TXA2-mimetic U46619-induced contractions of human, guinea-pig, rat and ferret airway smooth muscle with pA2 values between 8.0 and 8.9 and with no inherent contractile activity (10(-9)-10(-4) M).
(18) The overall pattern of decreased glucose use seen with progabide was different from that noted with previously studied GABA-mimetic drugs, such as muscimol, except for those changes observed in the extrapyramidal and sensory-motor areas for which similar dose-response relationships occurred.
(19) Peptides of portions of loop 2 (the "toxic" loop) of snake venom curare-mimetic neurotoxins (alpha-bungarotoxin and king cobra toxin b) and of a structurally similar region of the rabies virus glycoprotein were synthesized.
(20) Relaxation to bradykinin of rings contracted with the thromboxane A2 mimetic U-46619 was not affected by L-NMMA and was only minimally inhibited by methylene blue.
Mimic
Definition:
(a.) Alt. of Mimical
(n.) One who imitates or mimics, especially one who does so for sport; a copyist; a buffoon.
(v. t.) To imitate or ape for sport; to ridicule by imitation.
(v. t.) To assume a resemblance to (some other organism of a totally different nature, or some surrounding object), as a means of protection or advantage.
Example Sentences:
(1) The mechanism by which gp55 causes increased erythroblastosis and ultimately leukaemia is unknown, but a reasonable suggestion is that gp55 can mimic the action of erythropoietin by binding to its receptor (Epo-R), thereby triggering prolonged proliferation of erythroid cells.
(2) The present study explored the possibility that SOD-mimics such as desferrioxamine-Mn(III) chelate [DF-Mn] or cyclic nitroxide stable free radicals could protect from O2-.-independent damage.
(3) In physiological studies CDS mimics clonidine's action as an inhibitor of the electrically induced twitch response and as a partial agonist of the epinephrine-induced platelet aggregation.
(4) It may be assumed that this trait in the evaluation of mimics is due to a constitutional and morbid process.
(5) Mimics are stars and the country’s finest impersonators have their own television shows.
(6) The diagnosis of porphyria was overlooked in some as the symptoms may mimic those of other acute illnesses, so that incomplete or incorrect death certificates have been issued.
(7) The neurotransmitter alterations which accompany aluminum neurofibrillary degeneration were examined in order to assess how closely they mimic those of Alzheimer's disease.
(8) of cAMP-dependent protein kinase (cAMP-PK) mimics this effect.
(9) Loads up to 2.5 kN were applied, without simulated muscle forces, to mimic the line-of-action of the resultant joint-force in a single-legged stance.
(10) Veryan has developed a stent – a metal mesh tube inserted in an artery – that mimics the natural swirl of the blood flow, which researchers have found improves outcomes for patients with circulation problems.
(11) To mimic physiological conditions, synaptosomes, which are pinched off presynaptic nerve termini, were used.
(12) Again, the ability of lead to mimic or mobilize calcium and activate protein kinases may alter the behavior of endothelial cells in immature brain and disrupt the barrier.
(13) ADP and ATP gamma S were able to mimic the ATP response, whereas AMP and adenosine were unable to elicit a Cl- current.
(14) This peptide appeared to be a strong agonist of FSH action, as measured by the ability to stimulate cAMP production, at concentrations as low as 10(-7) M. The observation that a synthetic peptide, in which (parts of) three earlier described receptor interaction sites are combined according to the three-dimensional model, can mimic the action of FSH, at 10(-7) M, shows that this model is useful to predict a conformational receptor-binding site in FSH and that combination of only a few amino acid residues from the alpha and beta chains of FSH in a small synthetic peptide is sufficient to transduce a signal upon binding to the receptor.
(15) These uncommon ulcers, which mimic carcinoma radiographically and were previously thought to be uniformly fatal, may occasionally heal spontaneously.
(16) Aminophylline and caffeine can mimic this effect; however, papaverine and 1-methyl-3-isobutylxanthine, at concentrations inhibitory to phosphodiesterase, are without effect on glucocorticoid receptor binding to DNA.
(17) There is thus need for models that could mimic such situations.
(18) The present findings demonstrate that exogenously administered cholinomimetics only partly mimic the action of endogenous acetylcholine in the hippocampus.
(19) Histopathologically, the lesions display caseating and noncaseating dermal granulomas that mimic those seen in tuberculosis, tuberculoid leprosy, sarcoidosis, and other diseases.
(20) Cardiac myxomas typically present as a triad of obstructive, embolic, and constitutional symptoms and thus mimic many more common systemic illnesses.