(1) Most anti-nicotinic acetylcholine receptor (AChR) antibodies in myasthenia gravis are directed against an immunodominant epitope or epitopes [main immunogenic region (MIR)] on the AChR alpha-subunit.
(2) The data challenge the concept that a MIR of the AChR is the principal stimulus for antibody production in MG and emphasize a potential pitfall in assuming seronegativity in MG on the basis of a single assay system.
(3) The likelihood of performing a surgical procedure in space will increase as the Soviet Mir space station is expanded and the Space Station Freedom becomes operational.
(4) Mir M7 is a spontaneous morphologically conditional mutant of Klebsiella pneumoniae which grows as round cells (cocci) at pH 7 and as normal rods at pH 5.8.
(5) The beta-subunits of insulin receptor in CHO, CIR-0, Monr-31, and MIR-2 were similarly phosphorylated.
(6) Amino acid composition was qualitatively similar in both strains, but Mir M7 cocci contained a higher amount of alanine and glucosamine.
(7) Eldar Mustafayev, a former Turkish Airlines representative who returned to farming when his employer left Crimea after the referendum, said the canal bringing drinking and irrigation water from Ukraine's Dnieper river into Crimea was dry near their village of Novy Mir.
(8) The mAb inhibition was not explainable by epitope competition because (1) the mAb was reactive with both Torpedo and human AChR, but antibodies in 85 of the MG sera did not bind to Torpedo AChR, and (2) the mAb blocked binding of rat anti-peptide antibodies to an alpha subunit region of the human AChR unrelated antigenically to the designated MIR region.
(9) This suggest that the majority of the human MG antibodies are also directed against the MIR.
(10) The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli and Klebsiella pneumoniae, 31 of which produced TEM-1, TEM-2, TEM-3, TEM-4, TEM-5, TEM-7, TEM-8, TEM-9, TEM-10, TEM-12, TEM-101, SHV-1, SHV-2, SHV-3, SHV-4, SHV-5, CAZ-2, MIR-1, or an unidentified extended-spectrum beta-lactamase with a pI of 5.95, with some strains producing multiple beta-lactamases.
(11) Mir Ali is a hotbed of al-Qaida and Taliban militancy that has borne the brunt of a sharp escalation in US attacks this year.
(12) Two-dimensional NMR experiments [correlated spectroscopy (COSY) and two-dimensional transferred nuclear Overhauser enhancement spectroscopy (TR-NOESY)] have been applied to study the interactions of a monoclonal antibody (mAb) directed to the main immunogenic region (MIR) of the acetylcholine receptor (AChR), and four synthetic decapeptides from the MIR.
(13) Nick Kanas, a psychiatrist at the University of California, San Francisco, who has studied astronauts on the international space station and the Russian Mir station, said the crew face a tough time.
(14) The computer program MIR previously described (R. Bianchi, G.M.
(15) Fab fragments of an anti-MIR monoclonal antibody (mAb) or a mAb to the beta-subunit (neither of which causes antigenic modulation) were allowed to shield their corresponding regions on the AChR on the mouse muscle cell line BC3H1.
(16) Indices of JE transmission activity (vector abundance, pig seroconversions, and MIRs) increased proportionately with rainfall.
(17) We report the isolation and characterization of a strain of Bacillus, designed MIR 15, which appears to produce and excrete antimicrobials active against Gram-negative bacteria, but not against fungi.
(18) Chick dorsal root ganglion neurons thought to lack nicotinic acetylcholine receptors were not labeled by the anti-MIR mAb.
(19) The patient underwent a CT scan and MIR which showed a diffuse involvement of the ilium and sacrum along with the presence of two cysts (anterior and posterior).
(20) This is interpreted as the contribution to antigenic modulation of the anti-MIR antibody fraction in the human sera.
Mire
Definition:
(n.) An ant.
(n.) Deep mud; wet, spongy earth.
(v. t.) To cause or permit to stick fast in mire; to plunge or fix in mud; as, to mire a horse or wagon.
(v. t.) To soil with mud or foul matter.
(v. i.) To stick in mire.
Example Sentences:
(1) For decades, resource extraction on First Nations land and chronically underfunded schools have left many of these communities mired in poverty, alcoholism and disease.
(2) Our computer-based corneal topography analysis system was used to study the keratoscope photographs (keratograms) from two patients with classic pellucid marginal degeneration and a third patient with no inferior corneal thinning, whose keratoscope mire pattern was suggestive of the condition.
(3) With an out-of-session Congress deadlocked over immigration reform and right-wing lawmakers hell-bent on “sealing the border”, the White House faces intense pressure to do something – anything – about immigration, after years of burying a civil rights crisis in a mire of political tone-deafness and jingoistic bombast.
(4) A leading thinktank has forecast that Britain will remain mired in recession this year, and slashed growth forecasts for almost all members of the G7 group of leading industrial nations.
(5) The European commission released a statement about the situation later on Wednesday, less than two weeks after agreeing a rescue deal for Greece that was meant to prevent Italy and Spain being dragged into the mire.
(6) The discovery of "serious failings" in the sale of these so-called interest rate swaps comes as the banking industry is mired in controversy about manipulating interest rates following the record-breaking £290m fine slapped on Barclays on Wednesday.
(7) Since the incumbent, Ilham Aliyev, inherited power from his late father 10 years ago, Azerbaijan has become mired in rampant corruption , and the ruling regime has grown ever more authoritarian and ruthless .
(8) The French president, François Hollande , will have 25 minutes on primetime television on Sunday evening to convince his nation that he will keep his election pledges and drag his country out of the economic mire.
(9) But I was wrong to peg Let’s Be Cops down in the mire with the Scary Movie franchise.
(10) Mired in a deepening recession, with the economy projected to shrink by at least 2.4% this year, Italy also posted more bad news, with retail sales figures for July showing a 3.2% fall on a year ago.
(11) Dismayingly, the elected government of the president, Ashraf Ghani, like that of Hamid Karzai before it, has proved incompetent, divided, and mired in corruption .
(12) Hunt also argued that the current "sink or swim system" in which free schools, academies and academy chains were managed by Whitehall, had left the school landscape mired in incoherence, confusion and lack of accountability.
(13) A government investigation into his death has become mired in controversy after a judge nominated to head the probe said he would not participate.
(14) The economy has been mired in recession for six consecutive quarters - the longest slump in history – but the CBI now expects output to grow by 1.2% in 2010 and by 2.5% in 2011.
(15) This is an attempt to increase choice and drive digital switchover, which is mired in difficulty but another key duty.
(16) Companies have cut staff and costs to the bone , but demand remains sluggish in the US, and Europe is still mired in a financial crisis of historic proportions.
(17) Her response on a Seattle cable channel to Barack Obama’s state of the nation address in January, in which she accused the president of betraying Americans mired in poverty , spread via the internet and reinforced her growing reputation among activists outside Seattle.
(18) The margin of victory was still a comfortable 95 runs, and the win lifts Warwicks well out of the relegation zone, while leaving Kent deeper in the mire.
(19) One small shareholder, who introduced himself as Captain Hawker, said BP had stepped into a “PR nightmare” by handing out such largesse when the rest of the country was mired in austerity.
(20) Last year 87% of the 900,000 migrants making the journey to Europe came through Greece but, following the European Union’s new deal with Turkey , smugglers’ gangs are already sizing up Libya – which is mired in the chaos of civil war – as an alternative route.