(1) Most anti-nicotinic acetylcholine receptor (AChR) antibodies in myasthenia gravis are directed against an immunodominant epitope or epitopes [main immunogenic region (MIR)] on the AChR alpha-subunit.
(2) The data challenge the concept that a MIR of the AChR is the principal stimulus for antibody production in MG and emphasize a potential pitfall in assuming seronegativity in MG on the basis of a single assay system.
(3) The likelihood of performing a surgical procedure in space will increase as the Soviet Mir space station is expanded and the Space Station Freedom becomes operational.
(4) Mir M7 is a spontaneous morphologically conditional mutant of Klebsiella pneumoniae which grows as round cells (cocci) at pH 7 and as normal rods at pH 5.8.
(5) The beta-subunits of insulin receptor in CHO, CIR-0, Monr-31, and MIR-2 were similarly phosphorylated.
(6) Amino acid composition was qualitatively similar in both strains, but Mir M7 cocci contained a higher amount of alanine and glucosamine.
(7) Eldar Mustafayev, a former Turkish Airlines representative who returned to farming when his employer left Crimea after the referendum, said the canal bringing drinking and irrigation water from Ukraine's Dnieper river into Crimea was dry near their village of Novy Mir.
(8) The mAb inhibition was not explainable by epitope competition because (1) the mAb was reactive with both Torpedo and human AChR, but antibodies in 85 of the MG sera did not bind to Torpedo AChR, and (2) the mAb blocked binding of rat anti-peptide antibodies to an alpha subunit region of the human AChR unrelated antigenically to the designated MIR region.
(9) This suggest that the majority of the human MG antibodies are also directed against the MIR.
(10) The three-dimensional and clavulanate double-disk potentiation tests were compared as procedures for the detection of extended-spectrum beta-lactamase production in 32 strains of Escherichia coli and Klebsiella pneumoniae, 31 of which produced TEM-1, TEM-2, TEM-3, TEM-4, TEM-5, TEM-7, TEM-8, TEM-9, TEM-10, TEM-12, TEM-101, SHV-1, SHV-2, SHV-3, SHV-4, SHV-5, CAZ-2, MIR-1, or an unidentified extended-spectrum beta-lactamase with a pI of 5.95, with some strains producing multiple beta-lactamases.
(11) Mir Ali is a hotbed of al-Qaida and Taliban militancy that has borne the brunt of a sharp escalation in US attacks this year.
(12) Two-dimensional NMR experiments [correlated spectroscopy (COSY) and two-dimensional transferred nuclear Overhauser enhancement spectroscopy (TR-NOESY)] have been applied to study the interactions of a monoclonal antibody (mAb) directed to the main immunogenic region (MIR) of the acetylcholine receptor (AChR), and four synthetic decapeptides from the MIR.
(13) Nick Kanas, a psychiatrist at the University of California, San Francisco, who has studied astronauts on the international space station and the Russian Mir station, said the crew face a tough time.
(14) The computer program MIR previously described (R. Bianchi, G.M.
(15) Fab fragments of an anti-MIR monoclonal antibody (mAb) or a mAb to the beta-subunit (neither of which causes antigenic modulation) were allowed to shield their corresponding regions on the AChR on the mouse muscle cell line BC3H1.
(16) Indices of JE transmission activity (vector abundance, pig seroconversions, and MIRs) increased proportionately with rainfall.
(17) We report the isolation and characterization of a strain of Bacillus, designed MIR 15, which appears to produce and excrete antimicrobials active against Gram-negative bacteria, but not against fungi.
(18) Chick dorsal root ganglion neurons thought to lack nicotinic acetylcholine receptors were not labeled by the anti-MIR mAb.
(19) The patient underwent a CT scan and MIR which showed a diffuse involvement of the ilium and sacrum along with the presence of two cysts (anterior and posterior).
(20) This is interpreted as the contribution to antigenic modulation of the anti-MIR antibody fraction in the human sera.
Sir
Definition:
(n.) A man of social authority and dignity; a lord; a master; a gentleman; -- in this sense usually spelled sire.
(n.) A title prefixed to the Christian name of a knight or a baronet.
(n.) An English rendering of the LAtin Dominus, the academical title of a bachelor of arts; -- formerly colloquially, and sometimes contemptuously, applied to the clergy.
(n.) A respectful title, used in addressing a man, without being prefixed to his name; -- used especially in speaking to elders or superiors; sometimes, also, used in the way of emphatic formality.
Example Sentences:
(1) Businesses fleeing Brexit will head to New York not EU, warns LSE chief Read more Amid attempts by Frankfurt, Paris and Dublin to catch possible fallout from London, Sir Jon Cunliffe said it was highly unlikely that any EU centre could replicate the services offered by the UK’s financial services industry.
(2) However the imagery is more complex, because scholars believe it also relates to another cherished pre-Raphaelite Arthurian legend, Sir Degrevaunt who married his mortal enemy's daughter.
(3) At the moment the MPA makes the appointments in consultation with the Met commissioner, Sir Paul Stephenson.
(4) It has also been given to Sir Andrew Large, a former deputy governor of the Bank of England, whose report on lending failures by RBS will also be released on Monday.
(5) There on the street is Young Jo whose last words were, "I am wery symbolic, sir."
(6) It will form part of an investigation launched by the cabinet secretary, Sir Jeremy Heywood, on the orders of David Cameron to determine the British government's actions over the raid on Sikhism's holiest site in Amritsar.
(7) Sir James Crosby, the ITV senior independent non-executive director, explained why the board had opted to retain Grade's services for an extra year: "It was the unanimous view of ITV's independent non-executive directors that it would be in the best interests of the company and its shareholders to ask Michael to extend his time as executive chairman.
(8) Updated at 1.58pm BST 12.43pm BST Sir Malcolm Bruce, MP for Gordon, says there has been "a degree of intransigence" on both sides at Grangemouth, leading to today's closure.
(9) At a private meeting last Tuesday, Hunt assured Cameron and the cabinet secretary, Sir Jeremy Heywood, that he had not been aware that his special adviser, Adam Smith, was systematically leaking information and advice to News Corp about its bid for BSkyB.
(10) Yesterday streams of worshippers and tourists entered Sir Christopher Wren's building for Sunday services, apparently unconcerned by events outside.
(11) With respect to Sir Jimmy, those who proclaim the age of the train rarely get it right.
(12) The Dacre review panel, which included Sir Joseph Pilling, a retired senior civil servant, and the historian Prof Sir David Cannadine, said Britain now had one of the "less liberal" regimes in Europe for access to confidential government papers and that reform was needed to restore some trust between politicians and people.
(13) Facebook Twitter Pinterest Whether Sia, Jason Derulo, Coldplay’s Chris Martin or Sir Elton John is in the passenger seat, Corden plays the part of a real fan with a deep knowledge of their discography.
(14) We have the president of the tribunal, Sir Michael Burton, arguing that his work needs to be done in secret to secure the trust and co-operation of the intelligence services – but what about the trust of the British people and the confidence of the lawyers who seek to establish the rights of ordinary members of the public?
(15) The four members of the committee are all masters of wine, and the chairman is a retired diplomat, Sir David Wright.
(16) The validity of the response of this probe to Y-90 and its clinical application were assessed with a phantom containing varying activities and with biopsy samples obtained from patients being treated with SIR therapy.
(17) Sir James Crosby, the chief executive until 2006, was forced to resign as deputy chairman of the Financial Services Authority after the Treasury select committee produced allegations by a whistleblower that the bank was "going too fast".
(18) Leading figures including the musician Sting, business tycoon Sir Richard Branson and comedian Russell Brand have called for the possession of drugs to be decriminalised.
(19) Sir Philip Green has interesting tax arrangements but far from being labelled morally repugnant in a Mexico TV studio, he has got a government review to head up," she said.
(20) When last week’s scandal broke, Tesco chair Sir Richard Broadbent airily opined: “Things are always unnoticed until they are noticed.” He forgot to mention that that goes double if people are paid to turn a blind eye.