(v. t.) To form, as sound, to a certain key, or to a certain portion.
(v. t.) To vary or inflect in a natural, customary, or musical manner; as, the organs of speech modulate the voice in reading or speaking.
(v. i.) To pass from one key into another.
Example Sentences:
(1) The variation in thickness of the LLFL may modulate the species causing damage to the cells below it.
(2) These included bringing in the A* grade, reducing the number of modules from six to four, and a greater attempt to assess the whole course at the end.
(3) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) Gel filtration of the 40,000 rpm supernatant fraction of a homogenate of rat cerebral cortex on a Sepharose 6B column yielded two fractions: fraction II with the "Ca(2+) plus Mg(2+)-dependent" phosphodiesterase activity and fraction III containing its modulator.
(6) This modulation results from repetitive, alternating bursts of excitatory and inhibitory postsynaptic potentials, which are caused at least in part by synaptic feedback to the command neurons from identified classes of neurons in the feeding network.
(7) Modulation of the voltage-gated K+ conductance in T-lymphocytes by substance P was examined.
(8) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(9) This study examines the role of sex hormones in modulating the expression of autoimmunity in NZB x NZW F1 mice.
(10) More needs to be known about the direct and indirect modulation of cytokine production by cyclosporin A in connective tissues, in order to understand its potential value in clinical disorders.
(11) We suggest that neuronal PACAP may serve to modulate motor activity and secretion in the lower esophageal sphincter region.
(12) Furthermore, modulation of the assay by prostaglandin E2 (PGE2) was used to increase its sensitivity.
(13) Masking experiments are demonstrated for electrical frequency-modulated tone bursts from 1,000 to 10,000 cps and from 10,000 to 1,000 cps with superimposed clicks.
(14) From these results, BM-Eo are naive and seem to be a good indicator for eosinophilotaxis and its modulation.
(15) Administration of modulators in combinations of threes resulted in still further reduction of tumor incidences to 22.2% (SS + MC + AA), 19.2% (SS + MC + RA), 16% (MC + AA + RA) and 23.1% (AA + RA + SS).
(16) These findings suggest that activation of protein kinase C may act as a feedback inhibitor to modulate ligand-mediated increases in [Ca2+]i.
(17) These studies demonstrate that vWF interaction with GP Ib may be modulated by botrocetin binding to a discontinuous site located within residues 539-643.
(18) This contrasts sharply with the reduction in both the frequency and surface area of sensory neuron active zones that accompanies long-term habituation, and suggests that modulation of active zone number and size may be an anatomical correlate that lies in the long-term domain.
(19) Thus, it appears that the modulation of the phosphorylation of these cytosolic proteins represents an essential step in the regulation of T lymphocyte activation.
(20) Energy conformational calculations on these compounds were also carried out using the empirical energy program called MOLMEC, in order to better understand how the 4-R substituents modulate receptor binding affinities and efficacies.
Tone
Definition:
(n.) Sound, or the character of a sound, or a sound considered as of this or that character; as, a low, high, loud, grave, acute, sweet, or harsh tone.
(n.) Accent, or inflection or modulation of the voice, as adapted to express emotion or passion.
(n.) A whining style of speaking; a kind of mournful or artificial strain of voice; an affected speaking with a measured rhythm ahd a regular rise and fall of the voice; as, children often read with a tone.
(n.) A sound considered as to pitch; as, the seven tones of the octave; she has good high tones.
(n.) The larger kind of interval between contiguous sounds in the diatonic scale, the smaller being called a semitone as, a whole tone too flat; raise it a tone.
(n.) The peculiar quality of sound in any voice or instrument; as, a rich tone, a reedy tone.
(n.) A mode or tune or plain chant; as, the Gregorian tones.
(n.) That state of a body, or of any of its organs or parts, in which the animal functions are healthy and performed with due vigor.
(n.) Tonicity; as, arterial tone.
(n.) State of mind; temper; mood.
(n.) Tenor; character; spirit; drift; as, the tone of his remarks was commendatory.
(n.) General or prevailing character or style, as of morals, manners, or sentiment, in reference to a scale of high and low; as, a low tone of morals; a tone of elevated sentiment; a courtly tone of manners.
(n.) The general effect of a picture produced by the combination of light and shade, together with color in the case of a painting; -- commonly used in a favorable sense; as, this picture has tone.
(v. t.) To utter with an affected tone.
(v. t.) To give tone, or a particular tone, to; to tune. See Tune, v. t.
(v. t.) To bring, as a print, to a certain required shade of color, as by chemical treatment.
Example Sentences:
(1) The vascular endothelium is capable of regulating tissue perfusion by the release of endothelium-derived relaxing factor to modulate vasomotor tone of the resistance vasculature.
(2) In summary, GABAergic tone did not effect basal acid secretion in anesthetized rats.
(3) After midazolam infusion, there was a 50% decrease in amplitude of P3 in response to target tones (P less than 0.006), whereas N3 latency increased by 40 ms (P less than 0.05).
(4) All of this in the same tones of weary nonchalance you might use to stop the dog nosing around in the bin.
(5) More disturbing than his ideas was Malema's style and tone.
(6) Noradrenaline decreased the phasic contraction amplitude of the circular muscle and exerted a stimulant effect on the tone which suggested an existence of two alpha 1-adrenoceptor subtypes.
(7) Histamine (10(-6)-10(-4) M) induced concentration-dependent increases in tone and Ca2+i, but these responses were not sustained.
(8) Masking experiments are demonstrated for electrical frequency-modulated tone bursts from 1,000 to 10,000 cps and from 10,000 to 1,000 cps with superimposed clicks.
(9) The stimuli were two simple tones in experiment 1 and two tonal complexes in both experiments 2 and 3.
(10) Isolated outer hair cells from the organ of Corti of the guinea pig have been shown to change length in response to a mechanical stimulus in the form of a tone burst at a fixed frequency of 200 Hz (Canlon et al., 1988).
(11) Complex tones containing the first 20 harmonics of 50, 100, or 200 Hz, all at equal amplitude, were used.
(12) An attempt to eliminate the age effect by adjusting for age differences in monaural shadowing errors, fluid intelligence, and pure-tone hearing loss did not succeed.
(13) Inhibition of the production or action of these substances will allow for vasodilatation, and it is probable that perinatal pulmonary vascular tone reflects a balance between local prostaglandin and leukotriene production.
(14) Subject evaluations in accordance with the intensity levels of tones, i.e.
(15) Maximum expiratory flow on partial flow-volume curve at 25% forced vital capacity (PEF25) was measured as an index showing basal bronchomotor tone.
(16) Twenty-four hours later, a stimulus generalization test was conducted in the absence of drug; during this session, tones that varied in frequency around 4.5 KHz were presented while the animals were responding under the VI schedule.
(17) Auditory sensory perception was operationalized as number of tones heard on audiometric examination.
(18) Later, Lucas, also a former party leader, strongly defended Bennett, saying it was a “bad day for Natalie” but there was also “kind of a gloating tone that strikes one as having something to do with her being a woman in there too”.
(19) From a set of tones that varied only in intensity, it was possible to calculate the growth of loudness with intensity for the budgerigar.
(20) Two hundred forty-six fetuses had at least one abnormal biophysical profile variable with the risk of bad outcome, for a single abnormal variable, ranging from 8% (body movements) to 100% (tone) and increasing from 14% (any variable abnormal) to 63% (all variables abnormal).