(n.) Change; alteration, either in form or qualities.
Example Sentences:
(1) Neutrons induced a dose-dependent cytotoxicity and mutation frequency in the AL cells.
(2) The hprt T-cell cloning assay allows the detection of mutations occurring in vivo in the hypoxanthine-guanine phosphoribosyltransferase (hprt) gene of T-lymphocytes.
(3) The pathology resulting from a missense mutation at residue 403 further suggests that a critical function of myosin is disrupted by this mutation.
(4) Mutational mosaicism was used as a developmental model to analyze 1,500 sporadic and 179 familial cases of retinoblastoma from the world literature.
(5) Substances with a leaving group at the C-3 position form unsaturated conjugated cyclic adducts and are mutagenic only in the His D3052 frameshift strains with an intact excision repair system (no urvA mutation).
(6) The results are consistent with our previous suggestion that lethality for virulent SFV infection results from a lethal threshold of damage to neurons in the CNS and that attenuating mutations may reduce neuronal damage below this threshold level.
(7) It is concluded that selection against insertional mutations is unlikely to be the major factor involved in the containment of element abundance.
(8) Combination of domain substitutions to generate the [Glu107,123]bFGF and [Arg19,Lys123,126]bFGF mutants did not show any additivity of the mutations on biological activity.
(9) The plasmid pMucAMucB, constructed from the Haemophilus influenzae vector pDM2, and a similar plasmid, constructed from pBR322, increased the survival after UV irradiation of Escherichia coli AB1157 with the umu-36 mutation and also caused UV-induced mutation in the E. coli strain.
(10) Peptidoglycan synthesis is unaffected by the mutations affecting the core glycosyltransferases.
(11) The v-erb A oncogene of avian erythroblastosis virus is a mutated and virally transduced copy of a host cell gene encoding a thyroid hormone receptor.
(12) Genetical analysis revealed that resistance to trimethoprim resulted from forward mutations at separate loci rather than back mutations of rad 6 or rad 18 alleles.
(13) Studies on asparagine synthetase indicate that resistance to albizziin may be due to altered regulation of asparagine synthetase, structural mutations of the enzyme, and gene amplification.
(14) Mice with mutations in four nonreceptor tyrosine kinase genes, fyn, src, yes, and abl, were used to study the role of these kinases in long-term potentiation (LTP) and in the relation of LTP to spatial learning and memory.
(15) The apparent sensitivity of Escherichia coli K12 to mild heat was increased by recA (def), recB and polA, but not by uvrA, uvrB or recF mutations.
(16) Tumorigenesis is a multistep process involving mutations of dominantly acting proto-oncogenes and mutations and loss-of-function mutations of tumor suppressor genes.
(17) Appropriate mutations in this pre-early gene allowed a productive infection in ColIb+ cells.
(18) Technically speaking, this modality of brief psychotherapy is based on the nonuse of transferential interpretations, on impeding the regression od the patient, on facilitating a cognitice-affective development of his conflicts and thus obtain an internal object mutation which allows the transformation of the "past" into true history, and the "present" into vital perspectives.
(19) Mutant alleles of rutabaga act in the germ line cells to partially suppress the developmental defects caused by dunce mutations.
(20) The extensive conversion of anti-BPDE to B[a]PT-10-sulfonate under conditions where sulfite enhances diolepoxide mutagenicity, when coupled with this enhancement of diolepoxide mutagenicity by B[a]PT-10-sulfonate in the reverse mutation assay, supports this novel B[a]P derivative as a mediator of the sulfite-dependent enhancement of B[a]P genotoxicity.
Saltation
Definition:
(n.) A leaping or jumping.
(n.) Beating or palpitation; as, the saltation of the great artery.
(n.) An abrupt and marked variation in the condition or appearance of a species; a sudden modification which may give rise to new races.
Example Sentences:
(1) By the use of time-lapse microscopy to locate saltating particles prior to fixation and histochemical examination of the cells, structures of several kinds have been shown to move in this manner.
(2) Middlesevere cases (Hb 9-15 g%) showed in 57.2% an undulating and in 42.8% a saltatoring types of oscillation.
(3) The change in the orientation of pigment granule saltations following fertilization requires both a transient increase in the cytoplasmic concentration of Ca2+ and an elevation of cytoplasmic pH.
(4) Saltations in the unfertilized egg are very non-radial and are as likely to be directed toward the cortex as away.
(5) However, the appearance of saltations in such simple systems suggests that their appearance in a process as complex as biological evolution is not surprising.
(6) Bidirectional saltations are seen along the long axes of fully spread cells.
(7) The previous result of Rasminsky & Sears (1972) of delayed saltation in demyelinated nerve fibres was confirmed.
(8) In cases of severe fetal anemia (Hb less than 9 g%) we found at 64.2% a silent to narrowed undulating and at 21.4% saltatoring types of oscillations.
(9) It is suggested that such saltations may not represent more rapid rates of evolution but, rather, the persistence of evolutionary change in a given direction for a longer than normal period.
(10) Quantitation of vesicle saltations before and after fertilization demonstrates that while there is no significant difference in the speed or path-length of vesicle movement, there is a dramatic change in the orientation of these saltations.
(11) Immediately after injection, cells were recorded with a time-lapse video imaging system; later analysis of the tapes revealed that particles in cells injected with one of these antibodies (CG1, specific for CEF tropomyosin isoforms 1 and 3) showed a dramatic decrease in instantaneous speed while moving, distance moved per saltation, and proportion of time spent in motion.
(12) Saltations appear as a natural dynamical behavior in the evolution of simplistic information processing networks.
(13) Thus the 'larger vesicles' stopped moving at 25 degrees C, the small ones did not; both stopped at 18 degrees C. The 'small vesicles' continued to move actively after cell uptake of the polyanion poly-D-glutamic acid, while the saltations of the 'larger vesicles' were markedly slowed; both sets of vesicles stopped after uptake of ammonium chloride.
(14) Sequencing has revealed that the spacer DNA of X. laevis contains different kinds of simple DNA sequences, but no evidence has been found that spacer DNA once arose by saltation of a 15 bp segment.
(15) vignae revealed three categories of movement: a) general movement of cytoplasm, plus organelles, into the developing portions of the fungus during which the nuclei, in particular, maintained their characteristic position with remarkable constancy, b) relatively slow movements of various organelles such that they became displaced relative to one another and to the growing fungal tip, and c) erratic, rapid, saltations of small organelles over short distances.
(16) The co-transport of spectrin, actin, and calmodulin with cytomembranes undergoing rapid saltations departs from reported results of radioactive labeling experiments insofar as spectrin, actin, and calmodulin are not normally associated with rapidly transported membrane components in the latter studies.
(17) This transition must reflect underlying changes in the cellular structures necessary for pigment granule saltations.
(18) Trichocyst saltations end with either cortical insertion of the organelle, or return to cyclosis.
(19) Using acridine orange as a vital stain for acidic organelles, in combination with video-enhanced fluorescence microscopy, and subsequent immunolabeling with rabbit antibodies against ACTH, we have shown that these secretory granules move by saltations along the processes.
(20) This is the saltation phenomenon, and as presented in this theoretical note, it is a phenomenon which is easily accommodated by a theoretical rotation of space-time axes.