(1) One hour after direct mechanical cardiomassage (DMCM) a moderately pronounced edema of the intercellular spaces in the basal compartment of the seminiferous epithelium, normal content of lactate and succinate dehydrogenases, and a certain decrease in the activity of glucose-6-phosphate dehydrogenases and NAD- and NADP-diaphorases were noted.
(2) Transformed mammalian cells express both the usual NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase as well as the bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase.
(3) The results are discussed in terms of a two-site model in which separate, but interacting, regions exist on the enzyme to accommodate the adenosine and nicotinamide moieties of NAD, and a single-site model in which the adenosine part of the molecule is bound preferentially and this interacts with the nicotinamide fraction.
(4) The NAD-dependent enzymes (except alpha-GPDH) showed a stronger reactivity in the proximal tubules, while the NADP-dependent ones were more reactive in the thick limb of Henle's loop and distal convoluted tubules.
(5) In contrast, AMP and adenosine did not alter NAD glycohydrolase activity or affect subunit structure.
(6) With cortisol and cortisol-21-aldehyde, product inhibition patterns showed only slope effects with steroid product and NAD+, suggesting a "random" mechanism.
(7) Kinetic studies of glutamate dehydrogenase were made with wide concentration ranges of the coenzymes NAD(+) and NADP(+) and the substrates glutamate and norvaline.
(8) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(9) We investigated the denaturation of tetrameric 20 beta-hydroxysteroid dehydrogenase (20R)-17 beta,20 beta,21-trihydroxysteroid:NAD+ oxidoreductase, EC 1.1.1.53) to find out whether intermediate states are formed during the process.
(10) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(11) The effect of dicoumarol on glucuronidation of 3-OH-benzo(a)pyrene (BP) appears to be due to inhibition of UDPglucuronosyltransferase (UDPGT) and not to an inhibited DT-diaphorase (NAD(P)H:quinone oxidoreductase); to date the only enzyme known to be inhibited by dicoumarol.
(12) The increase in concentration of organic cosolvents results in a 2-2.5-fold increase of the maximal reaction rate and a decrease of Michaelis constant for formate of NAD(+)-dependent formate dehydrogenase from methylotrophic bacteria Pseudomonas sp.
(13) Furthermore, NADP was over 1000-fold more potent than NAD in inhibiting the enzyme competitively with respect to NADH.
(14) The possible participation of a Ca(2+)-induced activation of NAD-isocitrate dehydrogenase in this process was investigated.
(15) A 4.1-kb EcoRI fragment which includes the gene (gldA) encoding a glycerol dehydrogenase (G1DH; EC 1.1.1.6; glycerol:NAD oxidoreductase) from Bacillus stearothermophilus var.
(16) It is supposed that the stimulating effect of lactate with NAD+ on the mitochondria respiration is not so much a result of the membrane-damaged action as a result of oxidation of lactate dehydrogenase reaction products: phosphorylative oxidation of pyruvate and nonconjugated oxidation of NADH.
(17) In the presence of glycolate (glyoxylate), and NADH and NAD alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced and sustained by the addition of malate.
(18) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(19) The methods described make possible the preparation of fossil samples for light nad transmission electron microscopy.
(20) The activity of soluble NAD-specific hydrogenase was not detected.
Nay
Definition:
(adv.) No; -- a negative answer to a question asked, or a request made, now superseded by no. See Yes.
(adv.) Not this merely, but also; not only so, but; -- used to mark the addition or substitution of a more explicit or more emphatic phrase.
(n.) Denial; refusal.
(n.) a negative vote; one who votes in the negative.
(v. t. & i.) To refuse.
Example Sentences:
(1) Although NaY and NaG are effective heavy metal chelators and renal function is spared and kidney platinum levels are substantially reduced by the dithiocarbamates, no parallel loss of antineoplastic activity by Cis-Pt on the rat Walker carcinoma was observed.
(2) "She was jealous of the past, but she'd have done better being jealous of the future," political commentator Catherine Nay said this week.
(3) By contrast, the latter mutants designated mafB were defective in replication of nay of these plasmids at a high temperature.
(4) But at other times it's fine – nay, fantastic – to just let the saltiness shine, as in these olive choux buns.
(5) In doing so, we must learn to acknowledge- nay embrace- its innate goodness, decency and beauty.
(6) The National Review's Robert Costa says it looks good: Robert Costa (@robertcostaNRO) Leadership sources: no snags right now on informal whip count, legislation continues to move twd floor, vote coming later October 15, 2013 Except: Robert Costa (@robertcostaNRO) Pressure mounts on conservatives to vote nay RT @Heritage_Action Key Vote: “NO” on House Spending and Debt Deal October 15, 2013 The failure of the latest Boehner initiative could make a strong argument for the terminal paralysis of the House and the return of the legislative initiative to the Senate.
(7) What's insulting is that despite decades, nay centuries, of women's political activism, and despite years of hard work aimed at opening politics up to those from less privileged backgrounds, in 2010 we're still being presented with the same old same old.
(8) Renal damage, as estimated by blood urea nitrogen (BUN) values and serum creatinine levels, was less at all times up until sacrifice in animals given NaY or NaG than in those given DDTC.
(9) The nay-sayers argue that it will waste billions of pounds when a straightforward upgrade of the west coast line would do just as good a job without tearing up idyllic parts of Buckinghamshire, Warwickshire and Northamptonshire.
(10) It's not that they say, yea or nay regarding your right to speech, but can this be handled that it doesn't dramatically and drastically impact the rest of society?"
(11) The nay-sayers insist loudly that they're "climate sceptics", but this is a calculated misnomer – scientific scepticism is the method of investigating whether a particular hypothesis is supported by the evidence.
(12) Back in 2012, Sunder Katwala of the thinktank British Future (talking of the pre-Olympic opening ceremony whinging), said that for those nay-saying: “their cynicism is a performative act of Britishness.” In a country that prefaces a litany of complaints with “mustn’t grumble”, we don’t need gene science to tell us how much we take pleasure in our role.
(13) The results of Study 1 suggested the existence of six MHLC clusters: pure internal; double external; pure chance; yea sayer; nay sayer, and believer in control.
(14) Two vaccinations by the conjunctival route, as in group D, would be simpler, more economical and at least as effective as the standard system of vaccination, and would have the advantage that vaccination could be done at nay age without risk of serological response.
(15) Wily David Carney chalked one up for the nay-saying ageists by outfoxing youngster Thomas Deng to execute a superb run and finish, one which was harder than it may have seemed.
(16) On Thursday, however, one could hardly imagine a more emollient, nay flattering, figure, than Dame Liz.
(17) Even contestants no one picks are showered, nay tsunami-ed, with praise.
(18) Elizabeth Warren on the presidency: Fifty shades of nay Read more “To be sure, Warren – and grassroots economic populism more broadly – was already a rising force well before our efforts began,” the group’s organizers wrote in preparation to fold last week.
(19) In the future, when it has two cameras for fully featured video conferencing, GPS and who knows what else built in (1080 HD TV reception and recording and nano projection, for example) and when the iBook store has recorded its 100-millionth download and the thousands of accessories and peripherals that have invented uses for iPad that we simply can't now imagine – when that has happened it will all have seemed so natural and inevitable that today's nay-sayers and sceptics will have forgotten that they ever doubted its potential.
(20) And if you listen well, you can tell if she is likely to play or nay.