(1) One hour after direct mechanical cardiomassage (DMCM) a moderately pronounced edema of the intercellular spaces in the basal compartment of the seminiferous epithelium, normal content of lactate and succinate dehydrogenases, and a certain decrease in the activity of glucose-6-phosphate dehydrogenases and NAD- and NADP-diaphorases were noted.
(2) Transformed mammalian cells express both the usual NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase as well as the bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase.
(3) The results are discussed in terms of a two-site model in which separate, but interacting, regions exist on the enzyme to accommodate the adenosine and nicotinamide moieties of NAD, and a single-site model in which the adenosine part of the molecule is bound preferentially and this interacts with the nicotinamide fraction.
(4) The NAD-dependent enzymes (except alpha-GPDH) showed a stronger reactivity in the proximal tubules, while the NADP-dependent ones were more reactive in the thick limb of Henle's loop and distal convoluted tubules.
(5) In contrast, AMP and adenosine did not alter NAD glycohydrolase activity or affect subunit structure.
(6) With cortisol and cortisol-21-aldehyde, product inhibition patterns showed only slope effects with steroid product and NAD+, suggesting a "random" mechanism.
(7) Kinetic studies of glutamate dehydrogenase were made with wide concentration ranges of the coenzymes NAD(+) and NADP(+) and the substrates glutamate and norvaline.
(8) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(9) We investigated the denaturation of tetrameric 20 beta-hydroxysteroid dehydrogenase (20R)-17 beta,20 beta,21-trihydroxysteroid:NAD+ oxidoreductase, EC 1.1.1.53) to find out whether intermediate states are formed during the process.
(10) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(11) The effect of dicoumarol on glucuronidation of 3-OH-benzo(a)pyrene (BP) appears to be due to inhibition of UDPglucuronosyltransferase (UDPGT) and not to an inhibited DT-diaphorase (NAD(P)H:quinone oxidoreductase); to date the only enzyme known to be inhibited by dicoumarol.
(12) The increase in concentration of organic cosolvents results in a 2-2.5-fold increase of the maximal reaction rate and a decrease of Michaelis constant for formate of NAD(+)-dependent formate dehydrogenase from methylotrophic bacteria Pseudomonas sp.
(13) Furthermore, NADP was over 1000-fold more potent than NAD in inhibiting the enzyme competitively with respect to NADH.
(14) The possible participation of a Ca(2+)-induced activation of NAD-isocitrate dehydrogenase in this process was investigated.
(15) A 4.1-kb EcoRI fragment which includes the gene (gldA) encoding a glycerol dehydrogenase (G1DH; EC 1.1.1.6; glycerol:NAD oxidoreductase) from Bacillus stearothermophilus var.
(16) It is supposed that the stimulating effect of lactate with NAD+ on the mitochondria respiration is not so much a result of the membrane-damaged action as a result of oxidation of lactate dehydrogenase reaction products: phosphorylative oxidation of pyruvate and nonconjugated oxidation of NADH.
(17) In the presence of glycolate (glyoxylate), and NADH and NAD alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced and sustained by the addition of malate.
(18) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(19) The methods described make possible the preparation of fossil samples for light nad transmission electron microscopy.
(20) The activity of soluble NAD-specific hydrogenase was not detected.
Wad
Definition:
(n.) Woad.
(n.) A little mass, tuft, or bundle, as of hay or tow.
(n.) Specifically: A little mass of some soft or flexible material, such as hay, straw, tow, paper, or old rope yarn, used for retaining a charge of powder in a gun, or for keeping the powder and shot close; also, to diminish or avoid the effects of windage. Also, by extension, a dusk of felt, pasteboard, etc., serving a similar purpose.
(n.) A soft mass, especially of some loose, fibrous substance, used for various purposes, as for stopping an aperture, padding a garment, etc.
(v. t.) To form into a mass, or wad, or into wadding; as, to wad tow or cotton.
(v. t.) To insert or crowd a wad into; as, to wad a gun; also, to stuff or line with some soft substance, or wadding, like cotton; as, to wad a cloak.
(n.) Alt. of Wadd
Example Sentences:
(1) It is suggested that this early immune maturity may play a role in the hardiness of WAD goats and in their relative resistance to helminth and protozoan infection as compared with local sheep.
(2) Six of the WAD goats carried natural infections of H. contortus and T. colubriformis and eight other (tracer) goats acquired their infections from a grass paddock artificially contaminated with H. placei, C. pectinata and C. punctata, during May to October.
(3) The structure and morphology of the sternum from 33 West African dwarf (WAD) and sixteen Danish Landrace breed goats were studied radiographically.
(4) Well, he doesn’t have a mandate to break the law and he doesn’t have a mandate for handing out big wads of cash out on the ocean,” she said.
(5) The osmotic fragility of erythrocytes of West African Dwarf (WAD) goats and of WAD sheep was determined at different temperatures and pH.
(6) Look,” Kasich said as he celebrated his big win in his home state of Ohio, “this is all I got.” At this point, he held open his suit jacket to reveal no counterfeit watches, concealed weapons or wads of cash.
(8) Other members of Congress have been hit with wads of "evidence" and demands for meetings by supporters of the birther movement.
(9) When the penalty fine was eventually paid the man peeled a £20 note from a wad of notes that would have choked a donkey.
(10) I sit in the control room for one session, as the composer leafs through a vast wad of papers, and calmly speaks directions to the assembled musicians on the other side of a glass divide.
(11) He and his entourage would spend raucous weekends in luxury resorts, paying with wads of cash pulled carelessly from their pockets.
(12) There are also discussed the infectious complications of the nasal wads and great stress is laid upon avoiding errors in therapeutical measures.
(13) Labor’s immigration spokesman Richard Marles said Abbott’s refusal to deny the practice had left the door wide open to the idea the government was handing wads of taxpayer’s cash to smugglers.
(14) One hundred fifty patients suffering from severe protein-calorie malnutrition, admitted in 1 month to the Pediatric wards of Wad Medani Hospital, Sudan, were classified according to the Wellcome classification.
(15) Even as he handed out wads of petrodollars to impoverished developing countries, their leaders mocked him behind his back for being a buffoon and a clown.
(16) Water samples from four areas [Kass, Kosti, Wad Medani and Omdurman] two of which are known for endemic goitre did not appear to have any goitrogenic effect in our preliminary experiment using porcine thyroid follicle cell preparations.
(17) Another three WAD goats were artificially infected with mixed cultures of L3 of the latter three nematodes, while five goats were inoculated with 1500-2000 L3 of H. contortus harvested from cultures incubated at 25-30 degrees C for 8 days either in the dark or under normal laboratory conditions.
(18) They didn’t feel like they needed to blow their wad in the trailers.” There’s not an ounce of cynicism in his enthusiasm.
(19) Just need to make it count in the red zone and not blow their metaphorical wad on stupid plays."
(20) At the end of the period of exposure the substance remaining on the skin was recovered with the aid of cotton wads or Tesa adhesive tape and the spectrum of metabolites in the skin and the rinsing fluid determined by thin-layer chromatography.