(1) The quinolinate synthetase B protein exists in all nadA and nadC mutants examined.
(2) The presence of cAMP + cAMP receptor protein was essential for the complete derepression of nadA while no effect was evident upon nadB.
(3) She alleged that Epstein went on to make her have sex with Nada Marcinkova, another female Epstein associate .
(4) The structure of the adducts is in conformity with the generation and reactions of dehydro NADA quinone methide (or its radical).
(5) Accordingly, desaturase enzyme preparation contained both o-diphenoloxidase activity and NADA quinone:NADA quinone methide isomerase activity.
(6) Resolution of the NADA desaturase system on Benzamidine Sepharose and Sephacryl S-200 columns yielded the above-mentioned quinone isomerase and NADA quinone methide:dehydro NADA isomerase.
(7) The present paper reports on the mechanism by which dehydro-NADA is oxidatively activated to form reactive intermediate(s) as revealed by pulse radiolysis, electron spin resonance spectroscopy, high performance liquid chromatography, and ultraviolet-visible spectroscopic analysis.
(8) Exogenously added NADA quinone was readily converted by these enzyme preparations to N-acetylnorepinephrine and dehydro NADA.
(9) High-copy-number vectors, carrying either gene nadA, nadB or nadA + nadB, increased quinolinate production 1.5-fold, 2.0-fold and 15-fold respectively.
(10) After ecdysis NADA became the major hemolymph catecholamine in all species as DA decreased rapidly.
(11) The NADA desaturase system which converts NADA to 1,2-dehydro-NADA, surprisingly, does not resemble dehydrogenases such as succinate dehydrogenase.
(12) NADA-sulphate was quantified by an HPLC-ECD method while the decrease in 4-MU was monitored continuously by a fluorimetric procedure.
(13) These studies indicate that NADA quinone is an intermediate during the side chain hydroxylation of NADA by Manduca cuticular enzyme(s).
(14) The remaining nicotinamide mononucleotide accumulates extracellularly and will support the growth of nadA pncB mutants which cannot utilize the nicotinamide resulting from the major pathway of NAD degradation.
(15) In addition, the sulfate conjugate formed, namely N-acetyldopamine-sulfate (NADA-sulfate) was quantified directly by high-pressure liquid chromatography cum electrochemical detection (HPLC-ECD).
(16) Kinetic studies with NADA showed two pH optima of 6.7 and 8.6 for the overall sulphate conjugation and the PST reaction while the PAPS generation occurred maximally at pH 8.0.
(17) Reconstitution of NADA side chain desaturase activity was achieved by mixing the last enzyme fraction with NADA quinone isomerase, obtained from the hemolymph of the same organism, and mushroom tyrosinase.
(18) Evidence for the formation of an unstable intermediate in the synthesis of quinolinate from aspartate and dihydroxyacetone phosphate by Escherichia coli was obtained using toluenized cells of nadA and nadB mutants of this organism and partially purified A and B proteins in dialysis and membrane cone experiments.
(19) Media coverage was, not surprisingly, sparse – one interview for Melody Maker is vague to the point of rendering itself totally “nada”, while an Island press release is something of a bad joke.
(20) Confirmation of the operon arrangement for nadA and pnuC was obtained through the sequence analysis of a 2.4-kilobase DNA fragment which complemented both NadA and PnuC mutant phenotypes.
Something
Definition:
(n.) Anything unknown, undetermined, or not specifically designated; a certain indefinite thing; an indeterminate or unknown event; an unspecified task, work, or thing.
(n.) A part; a portion, more or less; an indefinite quantity or degree; a little.
(n.) A person or thing importance.
(adv.) In some degree; somewhat; to some extent; at some distance.
Example Sentences:
(1) I ask a friend to have a stab at, “down at cafe that does us butties”, and he said: “Something to do with his ass?” “Whose arse?” He looked panicked.
(2) It shows that the outside world is paying attention to what we're doing; it feels like we're achieving something."
(3) Amid the acrimony of the failed debate on the Malaysia Agreement, something was missed or forgotten: many in the left had changed their mind.
(4) It is an intriguing moment: the new culture secretary, Sajid Javid, who was brought in to replace Maria Miller last month, is something of an unknown quantity.
(5) Mr Heine suggested: "It is saying something about CND, nuclear power, Chernobyl and Nagasaki."
(6) The mother in Arthur Ransome's children's classic, Swallows and Amazons, is something of a cipher, but her inability to make basic decisions does mean she receives one of the finest telegrams in all literature.
(7) After friends heard that he was on them, Brumfield started observing something strange: “If we had people over to the Super Bowl or a holiday season party, I’d notice that my medicines would come up short, no matter how good friends they were.” Twice people broke into his house to get to the drugs.
(8) Michele Hanson 'The heat finally broke – I realised something had to change …' Stuart Heritage (right) with his brother in 2003.
(9) If we’re waiting around for the Democratic version to sail through here, or the Republican version to sail through here, all those victims who are waiting for us to do something will wait for days, months, years, forever and we won’t get anything done.” Senator Bill Nelson, whose home state of Florida is still reeling from the Orlando shooting, said he felt morally obligated to return to his constituents with results.
(10) "Maybe dullness is associated with psychic pain," Wallace wrote at one point, "because something that's dull or opaque fails to provide enough stimulation to distract people from some other, deeper type of pain that is always there, if only in an ambient low-level way, and which most of us spend nearly all our time and energy trying to distract ourselves from."
(11) He was often detained and occasionally beaten when he returned to Minsk for demonstrations, but “if he thought it was professional duty to uncover something, he did that no matter what threats were made,” Kalinkina said.
(12) You might even arrive home with something tolerable for supper.
(13) When I told my friend Rob that I was coming to visit him in Rio, I suggested we try something a bit different to going to the beach every day and drinking caipirinhas until three in the morning.
(14) At least Depay departed having had a shot on target, something his manager will probably offer as proof United are improving.
(15) In saying what he did, he was not telling any frequent flyer something they didn't already know, and he was not protesting about any newly adopted measures.
(16) Later, Lucas, also a former party leader, strongly defended Bennett, saying it was a “bad day for Natalie” but there was also “kind of a gloating tone that strikes one as having something to do with her being a woman in there too”.
(17) There can’t be something, someone that could fix this and chooses not to.” Years of agnosticism and an open attitude to religious beliefs thrust under the bus, acknowledging the shame that comes from sitting down with those the world forgot.
(18) Over the years it has become something of a Westminster ritual.
(19) Women in their 20s Christina Wallace , Director, Startup Institute of New York I do think the women's movement is stalled – especially since it's just not something my generation really thinks about.
(20) "We have accomplished something that has never happened before," the 68-year-old said.