(n.) That point of the heavens, or lower hemisphere, directly opposite the zenith; the inferior pole of the horizon; the point of the celestial sphere directly under the place where we stand.
(n.) The lowest point; the time of greatest depression.
Example Sentences:
(1) Following parturition, NONLAC cows averaged 4.0 d to negative EB nadir and 14.3 d to first ovulation.
(2) Seven days of constant light, however, reverses this diurnal variation such that plasma prolactin levels peak at 11:30 AM and reach a nadir at approximately 11:30 PM.
(3) Microsomal protein synthesis as measured by [3H]leucine incorporation was also depressed in a dose-dependent fashion; however, inhibition did not reach the nadir until day 4, 1 day after renal dysfunction was established.
(4) A trend to a phase-advance of cortisol nadir and melatonin peak was seen in the acutely ill depressed patients with abnormal DST, possibly indicating an involvement of the suprachiasmatic nuclei in the hypothalamus.
(5) The time-related incidence of these cells entities--the appearance of "dusk" and "bright" cells at 5 min, transitory domination of "bright" cells and the nadir of "dusk" cells at 20 min, sporadic recognition of "bright" cells, lack of "dusk" cells at 45 min and the absence of both cell forms at 180 min--displayed that LP-reactive response promptly appeared and rapidly ceased.
(6) In women, but not in men, there was a rise in the risk of falling from 45 years, peaking in the 55-59 year age group, and sinking to a nadir at ages 70-74.
(7) The binding is highest in the early morning and reaches a nadir in the late afternoon.
(8) Strict criteria for dose adjustments according to nadir counts were applied.
(9) One became azoospermic at week 16, while the other's total sperm counts continued declining and reached a nadir of 1.4 million by week 20.
(10) The WBC nadir occurred at a median of 10 days and the median time required for normalization of the WBC was 18 days.
(11) The main toxicity was haematological with delayed leucopenia and thrombopenia (nadir: week 6).
(12) Nadir values coincided with maximal toxic granulation of the neutrophils.
(13) The circadian rhythm observed in patients with intermittent claudication has early evening peaks and a nocturnal trough with a nadir occurring after midnight and before 0400.
(14) Portsmouth , still looking for their first home win under Tony Adams, dominated the first 25 minutes, when Nadir Belhadj was outstanding.
(15) Pre-treatment concentrations of P-FN were within the reference range and significantly higher than the nadir value (p less than 0.05).
(16) A model was constructed according to these two parameters that significantly describes ln (nadir WBC) (p = 0.001).
(17) Following spontaneous horizontal roving eye movement, both eyes deviated downward slowly from midposition, taking 1 to 2 seconds to reach the nadir.
(18) Griffiths replaced Nadir Ciftci for the start of the second half after a dismal first 45 minutes from the home side and Ronny Deila’s men continued to struggle, with Bitton sent off in the 67th minute after picking up his second yellow card.
(19) The second pulse was of slightly lower amplitude, reaching a maximum of 2.3 to 8.0 fold over the control value and 1.25 to 2.5 fold over the preceding nadir.
(20) The period from 2004-5 was the nadir: some American DJs even emigrated to Berlin, where the work prospects were better.
Pinnacle
Definition:
(n.) An architectural member, upright, and generally ending in a small spire, -- used to finish a buttress, to constitute a part in a proportion, as where pinnacles flank a gable or spire, and the like. Pinnacles may be considered primarily as added weight, where it is necessary to resist the thrust of an arch, etc.
(n.) Anything resembling a pinnacle; a lofty peak; a pointed summit.
(v. t.) To build or furnish with a pinnacle or pinnacles.
Example Sentences:
(1) Pinnacle, one of the biggest MPPI providers, blames "wider global financial uncertainty".
(2) For actors of a certain masculine bent, James Bond has long been viewed as a career pinnacle.
(3) The prize for doing that, however, would be the pinnacle of a scientific career.
(4) The takeaway from this pinnacle study is that securing protected areas alone is not enough.
(5) Another said: "The problem with PMQs isn't so much that it's shouty but that the so-called pinnacle of political debate in this country is two men trading petty insults and making nasty jokes about the other while the rest of parliament boos and cheers behind them.
(6) "Winning Wimbledon is the pinnacle of tennis," Murray said afterwards, still in something of a daze a good half hour after the final point.
(7) At the Montenvers railway turn right and zigzag easily up the extra 150m to grab great views of the pinnacles of the Aiguille Verte at 4,122m, Les Drus and the Mer de Glace (sea of ice).
(8) The quarter-final appearances under Sven-Göran Eriksson in two previous World Cups and one European championship in Portugal will now be seen as the pinnacle of their collective achievement.
(9) Suzy Rojtman, of the French national collective for women’s rights, said: “If we have a lot of attackers from the top political class who can harass and assault people unpunished at the pinnacle of the system of political power, think about what others in society are getting away with.” French female journalists are fighting back against sexist politicians | Lénaïg Bredoux Read more Caroline De Haas, a high-profile feminist and former government adviser, said sexual harassment was not unique to France, but in French politics it was happening with a sense of impunity and “an absence of understanding of what violence is to women”.
(10) Our political class is indeed the pinnacle of smug regurgitation.
(11) Parbuckling is a common means of salvaging wrecked vessels, but it has never been used on one of the Concordia's size – the cruise ship is 290 metres (950ft) long – let alone one balancing precariously on two rock pinnacles on a steep slope.
(12) With relatively gentle trail gradients and relentless cliff-top views down to the eroded pinnacles of the lowlands, this is one of Africa's great trekking destinations.
(13) The Heron tower, which stands in Bishopsgate next to Liverpool Street station, has just opened, while several other towers are under development, including the Pinnacle, which is also in Bishopsgate.
(14) The model for this policy is the United States, which represents the pinnacle of private enterprise in the health field.
(15) The spacewalk is the pinnacle of any mission, and something that only a minority of astronauts get to do.
(16) Female chief executives like Ellen Pao may reach the pinnacle in business only to discover that they have risen to the top of a precarious “glass cliff”.
(17) Hodgson is the only man on the FA's shortlist – the body stressed that the meeting on Monday was less an "interview" and more "discussions" over the role – with the former Internazionale, Switzerland and Fulham manager having previously stressed that he perceives the job as "the pinnacle" of his career after previously missing out to Kevin Keegan in 1999 and Sven-Goran Eriksson two years later.
(18) Yet this headline – and the accompanying 6,000-word article attacking debt-fuelled growth – has sparked weeks of speculation over an alleged political feud at the pinnacle of Chinese politics between the president, Xi Jinping, and the prime minister, Li Keqiang, the supposed steward of the Chinese economy .
(19) Pinnacle says its policies offer "peace of mind and reassurance", and adds: "Customers can reduce the level of cover should they want."
(20) Pinnacles has one campsite on the east side of the park, which is more developed than the western entrance.