(n.) That point of the heavens, or lower hemisphere, directly opposite the zenith; the inferior pole of the horizon; the point of the celestial sphere directly under the place where we stand.
(n.) The lowest point; the time of greatest depression.
Example Sentences:
(1) Following parturition, NONLAC cows averaged 4.0 d to negative EB nadir and 14.3 d to first ovulation.
(2) Seven days of constant light, however, reverses this diurnal variation such that plasma prolactin levels peak at 11:30 AM and reach a nadir at approximately 11:30 PM.
(3) Microsomal protein synthesis as measured by [3H]leucine incorporation was also depressed in a dose-dependent fashion; however, inhibition did not reach the nadir until day 4, 1 day after renal dysfunction was established.
(4) A trend to a phase-advance of cortisol nadir and melatonin peak was seen in the acutely ill depressed patients with abnormal DST, possibly indicating an involvement of the suprachiasmatic nuclei in the hypothalamus.
(5) The time-related incidence of these cells entities--the appearance of "dusk" and "bright" cells at 5 min, transitory domination of "bright" cells and the nadir of "dusk" cells at 20 min, sporadic recognition of "bright" cells, lack of "dusk" cells at 45 min and the absence of both cell forms at 180 min--displayed that LP-reactive response promptly appeared and rapidly ceased.
(6) In women, but not in men, there was a rise in the risk of falling from 45 years, peaking in the 55-59 year age group, and sinking to a nadir at ages 70-74.
(7) The binding is highest in the early morning and reaches a nadir in the late afternoon.
(8) Strict criteria for dose adjustments according to nadir counts were applied.
(9) One became azoospermic at week 16, while the other's total sperm counts continued declining and reached a nadir of 1.4 million by week 20.
(10) The WBC nadir occurred at a median of 10 days and the median time required for normalization of the WBC was 18 days.
(11) The main toxicity was haematological with delayed leucopenia and thrombopenia (nadir: week 6).
(12) Nadir values coincided with maximal toxic granulation of the neutrophils.
(13) The circadian rhythm observed in patients with intermittent claudication has early evening peaks and a nocturnal trough with a nadir occurring after midnight and before 0400.
(14) Portsmouth , still looking for their first home win under Tony Adams, dominated the first 25 minutes, when Nadir Belhadj was outstanding.
(15) Pre-treatment concentrations of P-FN were within the reference range and significantly higher than the nadir value (p less than 0.05).
(16) A model was constructed according to these two parameters that significantly describes ln (nadir WBC) (p = 0.001).
(17) Following spontaneous horizontal roving eye movement, both eyes deviated downward slowly from midposition, taking 1 to 2 seconds to reach the nadir.
(18) Griffiths replaced Nadir Ciftci for the start of the second half after a dismal first 45 minutes from the home side and Ronny Deila’s men continued to struggle, with Bitton sent off in the 67th minute after picking up his second yellow card.
(19) The second pulse was of slightly lower amplitude, reaching a maximum of 2.3 to 8.0 fold over the control value and 1.25 to 2.5 fold over the preceding nadir.
(20) The period from 2004-5 was the nadir: some American DJs even emigrated to Berlin, where the work prospects were better.
Trough
Definition:
(n.) A long, hollow vessel, generally for holding water or other liquid, especially one formed by excavating a log longitudinally on one side; a long tray; also, a wooden channel for conveying water, as to a mill wheel.
(n.) Any channel, receptacle, or depression, of a long and narrow shape; as, trough between two ridges, etc.
Example Sentences:
(1) These observations were confirmed by the killing curves in pooled serum obtained at peak and trough levels.
(2) Plasma aldosterone peaked (p < 0.05) at 22 hours after operation, and argine vasopressin peaked (p < 0.05) at two hours and then declined (p < 0.05) to a trough at 24 hours.
(3) Our observations demonstrated that echographic coaptation of the aortic valve leaflets coincides with the trough of the aortic pressure incisura and the onset of A2.
(4) The goal of the expedition, led by Prof Ken Takai of the Japan Agency for Marine-Earth Science and Technology, was to study the limits of life at deep-sea vents in the Cayman Trough as part of a round-the-world voyage of discovery by the research ship RV Yokosuka .
(5) IDDM in Canterbury, New Zealand, presents in cycles of incidence peaks and troughs, each spanning 2-3 yr.
(6) No IgE circadian rhythm was validated in healthy children while a large amplitude (approximately equal to 30% of the 24 hours mean) circadian rhythm with 2 diurnal peaks and a nocturnal trough was demonstrated (P less than 0.0023) in the asthmatics.
(7) Trough levels of LH, however, are dependent on the frequency of LHRH-induced pulsatile LH secretion.
(8) Appropriate conditions for administering the drug by intravenous drip infusion to neonates and infants at ages of more than 1 week were investigated taking observed blood levels and achieved peak levels and trough levels calculated using the one-compartment open model into account.
(9) Dose limiting toxicities were observed in 9 of 10 patients with 12-h trough piritrexim concentrations greater than 0.5 microM, whereas only 2 of 7 patients with trough concentrations less than 0.5 microM experienced dose limiting toxicities.
(10) Both free and luciferase-bound B show similar negative circular dichroism in the region 330-475 nm with troughs at 375 and 380 nm, respectively.
(11) Whole blood steady-state trough concentrations of cyclosporine were measured by radioimmunoassay (RIA) and TDx assays employing monoclonal antibodies in 82 samples from 39 renal transplant patients.
(12) Regression analysis also showed a strong relationship between the area under the curve (AUC) from time 0 to 11 hours after the initial dose and the trough at steady state (r = 0.86).
(13) algebraic sum of these three cosine functions yielded a circadian waveform with peak-times occurring near 0300 and 1130 hr and a trough-time about 2200 hr.
(14) Group I represented the modified "over-the-top" technique with a deep cancellous bone trough and represented the most isometric tracking.
(15) Circular dichroic spectra of the lipophorins and apolipophorin from 190 to 250 nm showed a single trough at 218 nm and a peak at 194 nm.
(16) • The best ideas are tested by their peaks and troughs.
(17) During the estrous cycle, mitotic activity of the granulosa cells was highest at estrus in follicles less than 601 micron, and at diestrus in follicles greater than 600 micron; while the mitotic trough was at proestrus in all the follicles.
(18) Data analysis revealed a seasonal pattern in the monthly distribution of births, with the peak period observed during April-June, and a trough during November-January.
(19) The issues in CsA monitoring include selection of sample matrix, analytical method, dosing interval and the timing of trough measurements, the temporal relationship between measurements and physiological events such as toxicity, the concurrent presence of multiple other immunosuppressive agents, and the lack of "gold standards" for determining rejection, adequate immunosuppression, and toxicity.
(20) The addition of LTB4 to the microsomal fraction gave a type-I spectral change with a peak at around 390 nm and a trough at 422 nm, indicating a direct interaction of LTB4 with the cytochrome P-450.