(1) One hour after direct mechanical cardiomassage (DMCM) a moderately pronounced edema of the intercellular spaces in the basal compartment of the seminiferous epithelium, normal content of lactate and succinate dehydrogenases, and a certain decrease in the activity of glucose-6-phosphate dehydrogenases and NAD- and NADP-diaphorases were noted.
(2) Transformed mammalian cells express both the usual NADP-dependent trifunctional methylenetetrahydrofolate dehydrogenase-cyclohydrolase-synthetase as well as the bifunctional NAD-dependent methylenetetrahydrofolate dehydrogenase-cyclohydrolase.
(3) The results are discussed in terms of a two-site model in which separate, but interacting, regions exist on the enzyme to accommodate the adenosine and nicotinamide moieties of NAD, and a single-site model in which the adenosine part of the molecule is bound preferentially and this interacts with the nicotinamide fraction.
(4) The NAD-dependent enzymes (except alpha-GPDH) showed a stronger reactivity in the proximal tubules, while the NADP-dependent ones were more reactive in the thick limb of Henle's loop and distal convoluted tubules.
(5) In contrast, AMP and adenosine did not alter NAD glycohydrolase activity or affect subunit structure.
(6) With cortisol and cortisol-21-aldehyde, product inhibition patterns showed only slope effects with steroid product and NAD+, suggesting a "random" mechanism.
(7) Kinetic studies of glutamate dehydrogenase were made with wide concentration ranges of the coenzymes NAD(+) and NADP(+) and the substrates glutamate and norvaline.
(8) Both substances decreased the concentrations of NAD(+) in the islet cells to about 10% of the control values within 2h after injection.
(9) We investigated the denaturation of tetrameric 20 beta-hydroxysteroid dehydrogenase (20R)-17 beta,20 beta,21-trihydroxysteroid:NAD+ oxidoreductase, EC 1.1.1.53) to find out whether intermediate states are formed during the process.
(10) On subfractionation of this crude mitochondrial fraction with continuous sucrose density gradients, most of the activity of the three enzymes was found at a higher density than NAD+-isocitrate dehydrogenase and at about the same density as glutamate dehydrogenase, confirming earlier reported data for acetyl-CoA synthase.
(11) The effect of dicoumarol on glucuronidation of 3-OH-benzo(a)pyrene (BP) appears to be due to inhibition of UDPglucuronosyltransferase (UDPGT) and not to an inhibited DT-diaphorase (NAD(P)H:quinone oxidoreductase); to date the only enzyme known to be inhibited by dicoumarol.
(12) The increase in concentration of organic cosolvents results in a 2-2.5-fold increase of the maximal reaction rate and a decrease of Michaelis constant for formate of NAD(+)-dependent formate dehydrogenase from methylotrophic bacteria Pseudomonas sp.
(13) Furthermore, NADP was over 1000-fold more potent than NAD in inhibiting the enzyme competitively with respect to NADH.
(14) The possible participation of a Ca(2+)-induced activation of NAD-isocitrate dehydrogenase in this process was investigated.
(15) A 4.1-kb EcoRI fragment which includes the gene (gldA) encoding a glycerol dehydrogenase (G1DH; EC 1.1.1.6; glycerol:NAD oxidoreductase) from Bacillus stearothermophilus var.
(16) It is supposed that the stimulating effect of lactate with NAD+ on the mitochondria respiration is not so much a result of the membrane-damaged action as a result of oxidation of lactate dehydrogenase reaction products: phosphorylative oxidation of pyruvate and nonconjugated oxidation of NADH.
(17) In the presence of glycolate (glyoxylate), and NADH and NAD alone or together in physiological proportions, the rate of serine-to-glycerate conversion was enhanced and sustained by the addition of malate.
(18) Virazole 5'-phosphate was subsequently found to be a potent competitive inhibitor of inosine 5'-phosphate dehydrogenase (IMP:NAD(+) oxidoreductase, EC 1.2.1.14) isolated from Escherichia coli (K(m) = 1.8 x 10(-5) M) with a K(i) of 2.7 x 10(-7) M. Guanosine 5'-phosphate (GMP) was a competitive inhibitor of this enzyme with a K(i) of 7.7 x 10(-5) M. Virazole 5'-phosphate was similarly active against IMP dehydrogenase isolated from Ehrlich ascites tumor cells, with a K(i) of 2.5 x 10(-7) M. The K(m) for this enzyme was 1.8 x 10(-5) M, and the K(i) for GMP was 2.2 x 10(-4) M. These results suggest that the antiviral activity of Virazole might be due to the inhibition of GMP biosynthesis in the infected cell at the step involving the conversion of IMP to xanthosine 5'-phosphate.
(19) The methods described make possible the preparation of fossil samples for light nad transmission electron microscopy.
(20) The activity of soluble NAD-specific hydrogenase was not detected.
Naos
Definition:
(n.) A term used by modern archaeologists instead of cella. See Cella.
Example Sentences:
(1) It is concluded that the Nao+-Mgi2+ exchange system has an absolute requirement for ATP and that it is more probable that ATP is supplying energy for transport rather than activating transport by protein phosphorylation or simply by binding.
(2) Will Iain Duncan Smith confirm the facts in today's NAO report.
(3) Ko+ less than Nao+ less than Lio+ less than Mgo2+ reduce furosemide-resistant Rb+ inward leakage relative to cholineo+.
(4) On Tuesday the National Audit Office (NAO) published a report on financial management at the BBC saying the corporation should do more to streamline internal financial reporting, and monitor more closely whether its spending decisions were aligned with its strategic and editorial objectives.
(5) "The BBC's internal financial reporting and planning processes are slow and resource intensive," the NAO said.
(6) We want to build 1m more English homes by 2020, says government Read more “If it is to oversee the new programme effectively, then this must specifically include tracking sale proceeds and progress with the actual construction of new homes, and oversee the programme in a way that gives parliament and the taxpayer much greater assurance over the value for money achieved from all disposals.” A statement from the DCLG did not address the main criticisms contained within the PAC report, and repeated figures that had been disputed by the NAO.
(7) Under constant voltage clamp (-80 mV) inward currents were measured after the addition of Nao+ to 0-Na+ 0-Ca2+ saline and outward currents were measured after the addition of Cao2+ to 0-Na+ 0-Ca2+ saline.
(8) The public accounts committee, which receives reports from the NAO, has heavily criticised the corporation and the BBC Trust, which have resisted full disclosure .
(9) Housing is a key issue and this does not give me any confidence that the department has a grip on its own figures.” Jeremy Blackburn, head of policy at the Royal Institution of Chartered Surveyors, said: “The NAO report has shown what was suspected by many.
(10) Thompson concludes that the evidence given to the NAO and the PAC on 10 July was "inadequate, and in some important instances, very misleading testimony".
(11) The pre-briefing we’re seeing, tinkering with schedules, now going on about pay, it’s very, very threatening to an institution that’s loved, [even one] that needs to reform.” Jeremy Hunt was the last culture minister to try to increase NAO oversight at the BBC, in 2010.
(12) The NAO says the new patient records have been implemented in a tiny minority of trusts while other IT systems, such as the digitisation of x-ray images, have been achieved.
(13) However, the timing was “primarily driven by the desire to sell prior to the 2015 general election”, said the NAO.
(14) The NAO said the decision helped save around £1.5bn in future interest payments and ensured these bondholders contributed to the costs of nationalisation.
(15) Enrichment of erythrocytes with cholesteryl hemisuccinate caused a marked reduction in Li leak but did not change kinetic and thermodynamic properties of Lii-Nao countertransport of either normotensive persons or patients with essential hypertension.
(16) Recovery from a Ca2+ load caused by reversal of the Na+ gradient could be induced by removal of Cao2+ in the continuing absence of Nao+, indicating the importance of a Na(+)-independent [Ca2+]i-lowering system.
(17) The BBC said that the Broadcasting House redevelopment, in addition to its two other major capital projects included in today's NAO report, came at a time of "profound and unprecedented transformation".
(18) Nao inhibited ouabain binding in the absence of Ki or Ko, so Nao and Ko also act at different sites.
(19) The NAO also discovered instances in which departing managers were given large payoffs even after they had found work elsewhere, and examples of staff who were offered consultancy roles at the time of their departure.
(20) TV coverage of Wimbledon in 2008 was £700,000 above the BBC's approved budget of £3.5m, although the NAO emphasised that four out of the other five came in at or below budget.