(1) Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT).
(2) Improvements in antenatal diagnosis and in utero therapy facilitate appropriate management of pregnancy at risk for NAIT.
(3) There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT.
(4) Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition.
(5) Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus.
(6) Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus.
(7) Neonatal alloimmune thrombocytopenia (NAIT) is due to fetomaternal incompatibility for platelet specific antigens, most frequently HPA-1a (PLA1) and HPA-5b (BRa).
(8) A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT).
(9) An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
(10) This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
(11) The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA).
(12) Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb).
(13) Platelet specific alloantibodies cause neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP) and may be found in patients who are refractory to HLA-matched platelet transfusion.
(14) In accordance with established criteria, the Sra antigen represents the first example of a "private" platelet alloantigen that bears significance in rare instances of NAIT.
(15) We report our experience with the serological diagnosis of 14 NAIT cases using new performing techniques such as western blotting (WB) and MAIPA (monoclonal antibody specific immobilization of platelet antigens).
(16) This is a report of 39 cases of NAIT involving the HPA-5b antigen.
(17) Bra antibodies were from mothers of children with neonatal alloimmune thrombocytopenia (NAIT), and anti-Brb was found in the serum of a polytransfused patient.
(18) NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups.
(19) Immunization against these alloantigens is implicated in NAIT and poly-transfused patients.
(20) In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra.
Order
Definition:
(n.) Regular arrangement; any methodical or established succession or harmonious relation; method; system
(n.) Of material things, like the books in a library.
(n.) Of intellectual notions or ideas, like the topics of a discource.
(n.) Of periods of time or occurrences, and the like.
(n.) Right arrangement; a normal, correct, or fit condition; as, the house is in order; the machinery is out of order.
(n.) The customary mode of procedure; established system, as in the conduct of debates or the transaction of business; usage; custom; fashion.
(n.) Conformity with law or decorum; freedom from disturbance; general tranquillity; public quiet; as, to preserve order in a community or an assembly.
(n.) That which prescribes a method of procedure; a rule or regulation made by competent authority; as, the rules and orders of the senate.
(n.) A command; a mandate; a precept; a direction.
(n.) Hence: A commission to purchase, sell, or supply goods; a direction, in writing, to pay money, to furnish supplies, to admit to a building, a place of entertainment, or the like; as, orders for blankets are large.
(n.) A number of things or persons arranged in a fixed or suitable place, or relative position; a rank; a row; a grade; especially, a rank or class in society; a group or division of men in the same social or other position; also, a distinct character, kind, or sort; as, the higher or lower orders of society; talent of a high order.
(n.) A body of persons having some common honorary distinction or rule of obligation; esp., a body of religious persons or aggregate of convents living under a common rule; as, the Order of the Bath; the Franciscan order.
(n.) An ecclesiastical grade or rank, as of deacon, priest, or bishop; the office of the Christian ministry; -- often used in the plural; as, to take orders, or to take holy orders, that is, to enter some grade of the ministry.
(n.) The disposition of a column and its component parts, and of the entablature resting upon it, in classical architecture; hence (as the column and entablature are the characteristic features of classical architecture) a style or manner of architectural designing.
(n.) An assemblage of genera having certain important characters in common; as, the Carnivora and Insectivora are orders of Mammalia.
(n.) The placing of words and members in a sentence in such a manner as to contribute to force and beauty or clearness of expression.
(n.) Rank; degree; thus, the order of a curve or surface is the same as the degree of its equation.
(n.) To put in order; to reduce to a methodical arrangement; to arrange in a series, or with reference to an end. Hence, to regulate; to dispose; to direct; to rule.
(n.) To give an order to; to command; as, to order troops to advance.
(n.) To give an order for; to secure by an order; as, to order a carriage; to order groceries.
(n.) To admit to holy orders; to ordain; to receive into the ranks of the ministry.
(v. i.) To give orders; to issue commands.
Example Sentences:
(1) The predicted non-Lorentzian line shapes and widths were found to be in good agreement with experimental results, indicating that the local orientational order (called "packing" by many workers) in the bilayers of small vesicles and in multilamellar membranes is substantially the same.
(2) "As the investigation remains live and in order to preserve the integrity of that investigation, it would not be appropriate to offer further comment."
(3) The various evocational changes appear to form sets of interconnected systems and this complex network seems to embody some plasticity since it has been possible to suppress experimentally some of the most universal evocational events or alter their temporal order without impairing evocation itself.
(4) Treatment termination due to lack of efficacy or combined insufficient therapeutic response and toxicity proved to be influenced by the initial disease activity and by the rank order of prescription.
(5) The LD50 of the following metal-binding chelating drugs, EDTA, diethylenetriaminepentaacetic acid (DTPA), hydroxyethylenediaminetriacetic acid (HEDTA), cyclohexanediaminotetraacetic acid (CDTA) and triethylenetetraminehexaacetic acid (TTHA) was evaluated in terms of mortality in rats after intraperitoneal administration and was found to be in the order: CDTA greater than EDTA greater than DTPA greater than TTHA greater than HEDTA.
(6) Squadron Leader Kevin Harris, commander of the Merlins at Camp Bastion, the main British base in Helmand, praised the crews, adding: "The Merlins will undergo an extensive programme of maintenance and cleaning before being packed up, ensuring they return to the UK in good order."
(7) In order to control noise- and vibration-caused diseases it was necessary not only to improve machines' quality and service conditions but also to pay special attention to the choice of operators and to the quality of monitoring their adaptation process.
(8) The purpose of this paper is to discuss the potential for integrating surveillance techniques in reproductive epidemiology with geographic information system technology in order to identify populations at risk around hazardous waste sites.
(9) In order to determine the extent of this similarity, I have developed a panel of probes for many of the Pacl restriction fragments and have shown that most of the Pacl and Notl fragments found in MBa are also present in MBb.
(10) In addition to the phase diagrams reported here for these two binary mixtures, a brief theoretical discussion is given of other possible phase diagrams that may be appropriate to other lipid mixtures with particular consideration given to the problem of crystalline phases of different structures and the possible occurrence of second-order phase transitions in these mixtures.
(11) However, within 5 min potassium overcame the vanadate potentiation of ouabain binding regardless of the order in which it was added to the reaction mixture.
(12) The metabolism of [1,3-14C]benzo[f]quinoline (BfQ) by liver microsomes from control, 3-methylcholanthrene (3-MC)-pretreated and phenobarbital (PB)-pretreated rats has been investigated in order to gain insights into the effect of mixed function oxidase inducers on the types and levels of specific metabolites as formed in vitro.
(13) Friend erythroleukemia cells were induced to differentiate by dimethyl sulfoxide (DMSO) and hexamethylene-bis-acetamide (HBMA) in order to investigate whether their lipid characteristics, common to other systems of transformed cells, revert to a normal differentiation pattern.
(14) In order for the club to grow and sustain its ability to be a competitive force in the Premier League, the board has made a number of decisions which will strengthen the club, support the executive team, manager and his staff and enhance shareholder return.
(15) The present study was done in order to document the ability of the eighth cranial nerve of the bullfrog (Rana catesbeiana) to regenerate, the anatomic characteristics of the regenerated fibers, and the specificity of projections from individual endorgan branches of the nerve.
(16) In order to develop a sampling strategy and a method for analyzing the circadian body temperature pattern, we monitored estimates of the temperature in four ways using rectal, oral, axillary and deep body temperature from the skin surface every hour for 72 consecutive hours in 10 normal control subjects.
(17) I fear that I will have to go through another witch-hunt in order to apply for this benefit."
(18) A retrospective study was done in 86 patients on dialysis in order to evaluate the doses of aluminum hydroxide (OH3 Al) received to achieve a better serum phosphate control.
(19) Each test was examined by the frequency with which it was ordered, the frequency with which it was abnormal, and the frequency with which the abnormal result affected preoperative care.
(20) We have now started a prospective follow-up study in order to pursue the development of (a) p-ERG amplitudes and (b) funduscopic changes and visual acuity in these patients.