(1) Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT).
(2) Improvements in antenatal diagnosis and in utero therapy facilitate appropriate management of pregnancy at risk for NAIT.
(3) There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT.
(4) Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition.
(5) Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus.
(6) Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus.
(7) Neonatal alloimmune thrombocytopenia (NAIT) is due to fetomaternal incompatibility for platelet specific antigens, most frequently HPA-1a (PLA1) and HPA-5b (BRa).
(8) A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT).
(9) An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
(10) This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
(11) The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA).
(12) Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb).
(13) Platelet specific alloantibodies cause neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP) and may be found in patients who are refractory to HLA-matched platelet transfusion.
(14) In accordance with established criteria, the Sra antigen represents the first example of a "private" platelet alloantigen that bears significance in rare instances of NAIT.
(15) We report our experience with the serological diagnosis of 14 NAIT cases using new performing techniques such as western blotting (WB) and MAIPA (monoclonal antibody specific immobilization of platelet antigens).
(16) This is a report of 39 cases of NAIT involving the HPA-5b antigen.
(17) Bra antibodies were from mothers of children with neonatal alloimmune thrombocytopenia (NAIT), and anti-Brb was found in the serum of a polytransfused patient.
(18) NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups.
(19) Immunization against these alloantigens is implicated in NAIT and poly-transfused patients.
(20) In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra.
Refuse
Definition:
(v. t.) To deny, as a request, demand, invitation, or command; to decline to do or grant.
(v. t.) To throw back, or cause to keep back (as the center, a wing, or a flank), out of the regular aligment when troops ar/ about to engage the enemy; as, to refuse the right wing while the left wing attacks.
(v. t.) To decline to accept; to reject; to deny the request or petition of; as, to refuse a suitor.
(v. t.) To disown.
(v. i.) To deny compliance; not to comply.
(n.) Refusal.
(n.) That which is refused or rejected as useless; waste or worthless matter.
(a.) Refused; rejected; hence; left as unworthy of acceptance; of no value; worthless.
Example Sentences:
(1) We were instantly refused entrance by the heavies at the door.
(2) There are widespread examples across the US of the police routinely neglecting crimes of sexual violence and refusing to believe victims.
(3) Such a science puts men in a couple of scientific laws and suppresses the moment of active doing (accepting or refusing) as a sufficient preassumption of reality.
(4) There were no deaths but one refused to have ketamine again.
(5) That’s a criticism echoed by Democrats in the Senate, who issued a report earlier this month criticising Republicans for passing sweeping legislation in July to combat addiction , the Comprehensive Addiction and Recovery Act (Cara), but refusing to fund it.
(6) She successfully appealed against the council’s decision to refuse planning permission, but neighbours have launched a legal challenge to be heard at the high court in June.
(7) Tony Abbott has refused to concede that saying Aboriginal people who live in remote communities have made a “lifestyle choice” was a poor choice of words as the father of reconciliation issued a public plea to rebuild relations with Indigenous people.
(8) The military is not being honest about the number of men on strike: most of us are refusing to eat.
(9) But employers who have followed a fair procedure may have the right to discipline or finally dismiss any smoker who refuses to accept the new rules.
(10) Republican presidential hopeful Scott Walker has refused to say whether he believes in the theory of evolution, arguing that it is “a question a politician shouldn’t be involved in one way or the other”.
(11) But in a setback to the UK, Somaliland, which broke away from Somalia in 1991, refused British entreaties to attend on the grounds that it would not have been treated as equal to the Somali government.
(12) Ten patients had been treated by adrenalectomy, one patient by radiotherapy of the hypophysis, and one patient had refused any treatment.
(13) What if the court of justice refuses to answer the question?
(14) The only thing the media will talk about in the hours and days after the debate will be Trump’s refusal to say he will accept the results of the election, making him appear small, petty and conspiratorial.
(15) A small band of shadow cabinet members have lined up to refuse to serve in posts they haven’t even been offered, on the basis of objection to economic policies they clearly haven’t read.
(16) The prerequisite for all champions is the refusal to cave in, so City's equaliser with only three minutes remaining was pleasing.
(17) Black males with low intentions to use condoms reported significantly more negative attitudes about the use of condoms (eg, using condoms is disgusting) and reacted with more intense anger when their partners asked about previous sexual contacts, when a partner refused sex without a condom, or when they perceived condoms as interfering with foreplay and sexual pleasure.
(18) As long as Israel refuses to cease settlement activities and to the release of the fourth group of Palestinian prisoners in accordance with our agreements, they leave us no choice but to insist that we will not remain the only ones committed to the implementation of these agreements, while Israel continuously violates them,” Abbas said.
(19) The people who will lose are not the commercial interests, and people with particular vested interests, it’s the people who pay for us, people who love us, the 97% of people who use us each week, there are 46 million people who use us every day.” Hall refused to be drawn on what BBC services would be cut as a result of the funding deal which will result in at least a 10% real terms cut in the BBC’s funding.
(20) These letters are also written during a period when Joyce was still smarting from the publishing difficulties of his earlier works Dubliners and A Portrait of the Artist as a Young Man.” Gordon Bowker, Joyce’s biographer, agreed: “Joyce’s problem with the UK printers related to the fact that here in those days printers were as much at risk of prosecution on charges of publishing obscenities as were publishers, and would simply refuse to print them.