(1) Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT).
(2) Improvements in antenatal diagnosis and in utero therapy facilitate appropriate management of pregnancy at risk for NAIT.
(3) There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT.
(4) Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition.
(5) Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus.
(6) Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus.
(7) Neonatal alloimmune thrombocytopenia (NAIT) is due to fetomaternal incompatibility for platelet specific antigens, most frequently HPA-1a (PLA1) and HPA-5b (BRa).
(8) A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT).
(9) An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
(10) This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
(11) The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA).
(12) Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb).
(13) Platelet specific alloantibodies cause neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP) and may be found in patients who are refractory to HLA-matched platelet transfusion.
(14) In accordance with established criteria, the Sra antigen represents the first example of a "private" platelet alloantigen that bears significance in rare instances of NAIT.
(15) We report our experience with the serological diagnosis of 14 NAIT cases using new performing techniques such as western blotting (WB) and MAIPA (monoclonal antibody specific immobilization of platelet antigens).
(16) This is a report of 39 cases of NAIT involving the HPA-5b antigen.
(17) Bra antibodies were from mothers of children with neonatal alloimmune thrombocytopenia (NAIT), and anti-Brb was found in the serum of a polytransfused patient.
(18) NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups.
(19) Immunization against these alloantigens is implicated in NAIT and poly-transfused patients.
(20) In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra.
Skilful
Definition:
(a.) See Skilful.
Example Sentences:
(1) Agüero’s run was as strong as it was skilful, beating four attempted tacklers in a drive into the penalty area that ended with him poking the ball past Ruddy as the goalkeeper came out to narrow the angle.
(2) You can also blast individual eyeballs from their sockets, or – if you're particularly skilful – make their testicles explode like a pair of microwaved eggs.
(3) "Let us give a warm welcome to this book," announced Douglas Hurd in the Daily Telegraph, "partly because it is a subtle and skilful narrative and partly because we in Britain still do not know what to make of General Charles de Gaulle ."
(4) But Jeff Koons, as hard and as skilfully as he may try, will never trump Blackpool prom in its full illuminated autumn evening glory.
(5) By contrast, skilful application of blood pressure measuring devices will increase one's understanding of blood pressure physiology, pathology, and response to treatment.
(6) My message to the Government is to build on the changing climate they have inspired and invest skilfully and generously in our urban fabric so that we can feel proud of our cities and proud of being a citizen.
(7) "We are lucky to have in Chris Blackhurst a skilful and highly respected journalist with long experience of both the Independent and the Standard and I thank him for what he has achieved as editor of the Independent.
(8) The defence is well structured and they have a quartet of forwards that are very fast, with one very skilful player like Musa.
(9) He was English history's most famous hunchback, but a sharp tailor and a skilful armourer may have disguised the curve in his spine, according to experts who examined the skeleton which has been identified as Richard III's.
(10) Christine Slottvedd Kimbriel, paintings conservator at the institute, said this showed the painting was much more skilfully executed than had been thought.
(11) Lewins’ skilful, driven documentary fills the void left by Ali’s silence with the voices of those who know him – his brother, one of his ex-wives, his business manager, his trainer, his son and daughters – and those who watched and wrote about him when he ruled the ring.
(12) Even defectors describe him as a skilful politician with the foresight to understand that nuclear diplomacy is a marathon, not a sprint.But the rapid rise of his youngest son, about whom the world knew practically nothing until his first official appearance with his father in 2010, has produced a vainglorious leader who, says Kim Kwang-jin, is "running too fast and doesn't know how to slow down".
(13) For while Morsi has skilfully negotiated the first major foreign policy crisis since the fall of Hosni Mubarak's regime, that success masks a host of challenges ahead for him.
(14) They enjoy a spate of possession down the right wing starring an amazing cameo from Mills and his absurd mix of skilful jinks and hopeless close control.
(15) Neither is a household name in the way Ken Livingstone and Boris Johnson were in the contest four years ago, but both are skilful and fluent politicians.
(16) The archbishops’ essays’ real value is their willingness to ask questions about the boundaries of society – something we desperately need at a time when democratic politics can seem an ever more skilful way of deciding questions that interest fewer and fewer people.
(17) In the way he played, he was the embodiment of a Manchester United player – fast, skilful, entertaining and determined to win by playing exciting football.
(18) Nevertheless, when he wrote that Waugh was "brave, generous, funny and an extremely skilful writer," it may not have been the whole story, but it was a large and true part of it.
(19) Instead, wrath is skilfully misdirected by this government towards immigrants or the unemployed.
(20) She became a vociferous critic both of the supermarkets, and of the 80s "foodie" culture as satirised in The Official Foodie Handbook by Ann Barr and Paul Levy, a volume she loathed ("To be sure they are skilful enough in the arts of toadying to their public and providing it with a little giggle at itself, but the meaning of satire in the true sense eludes them," she wrote in her review for Tatler ).