(1) Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT).
(2) Improvements in antenatal diagnosis and in utero therapy facilitate appropriate management of pregnancy at risk for NAIT.
(3) There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT.
(4) Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition.
(5) Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus.
(6) Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus.
(7) Neonatal alloimmune thrombocytopenia (NAIT) is due to fetomaternal incompatibility for platelet specific antigens, most frequently HPA-1a (PLA1) and HPA-5b (BRa).
(8) A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT).
(9) An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
(10) This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
(11) The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA).
(12) Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb).
(13) Platelet specific alloantibodies cause neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP) and may be found in patients who are refractory to HLA-matched platelet transfusion.
(14) In accordance with established criteria, the Sra antigen represents the first example of a "private" platelet alloantigen that bears significance in rare instances of NAIT.
(15) We report our experience with the serological diagnosis of 14 NAIT cases using new performing techniques such as western blotting (WB) and MAIPA (monoclonal antibody specific immobilization of platelet antigens).
(16) This is a report of 39 cases of NAIT involving the HPA-5b antigen.
(17) Bra antibodies were from mothers of children with neonatal alloimmune thrombocytopenia (NAIT), and anti-Brb was found in the serum of a polytransfused patient.
(18) NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups.
(19) Immunization against these alloantigens is implicated in NAIT and poly-transfused patients.
(20) In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra.
Tait
Definition:
(n.) A small nocturnal and arboreal Australian marsupial (Tarsipes rostratus) about the size of a mouse. It has a long muzzle, a long tongue, and very few teeth, and feeds upon honey and insects. Called also noolbenger.
Example Sentences:
(1) Experimental work has established that a sexual process can occur in African trypanosomes (Jenni, Marti, Schweizer, Betschart, Le Page, Wells, Tait, Paindavoine, Pays & Steinert, 1986; Paindavoine, Zampetti-Bosseler, Pays, Schweizer, Guyaux, Jenni & Steinert, 1986; Tait, personal communication).
(2) Robert Tait is a senior correspondent for Radio Free Europe.
(3) Awards: 1954 Somerset Maugham Award (for Five, a collections of short stories); 1985, WH Smith Literary Award and the Mondello Prize for The Good Terrorist; 1994 James Tait Black Prize for Under my Skin; nominated for the 1996 Bad Sex Award iin the Literary Review.
(4) The statement was signed by Clare Solomon, president of the University of London Union, Cameron Tait, president of Sussex University's student union and Lee Hall, author of Billy Elliot, among others.
(5) Taite argues that just because it's luxurious doesn't mean clients always get their way.
(6) Tait described four categories of binocular disorders including convergence excess, convergence insufficiency, divergence excess, and divergence insufficiency.
(7) "I've had very influential people here," Taite says.
(8) I get about £130 a week once everything is added on, so this rise is very good,” Tait says.
(9) "These proposals offer countries the chance to buy their way out of reducing emissions through forest protection," said Greenpeace's head of biodiversity, Andy Tait.
(10) We recently identified residues 185-224 of the light chain of human high molecular weight kininogen (HMWK) as the binding site for plasma prekallikrein (Tait, J.F., and Fujikawa, K. (1986) J. Biol.
(11) Finally, if in doubt, all surgeons should recall the words of Halsteads in 1898 "No drainage at all is better than the ignorant employment of it" rather than the advice of Lawson Tait.
(12) Yesterday talks with the government were being led at the BBC by Thompson, chief operating officer Caroline Thomson, strategy chief John Tait and Lyons.
(13) Photograph: Christopher Thomond for the Guardian Valerie Tait reached state pension age 10 years ago but, at the age of 70, is still working part-time as a civil servant.
(14) But Tait is being replaced by a former BBC news executive, Richard Ayre, who was a member of Ofcom's content board until being appointed as a trustee.
(15) In a conventional protein fragmentation approach, the prekallikrein-binding site was mapped to positions 556-595 of the human H-kininogen sequence (Tait, J. F., and Fujikawa, K. (1986) J. Biol.
(16) By reporting successful treatment of tubal pregnancy with salpingectomy in 1884 Robert Lawson Tait (1845-1899) started an era of almost 70 years of exclusively extirpative treatment of ectopic pregnancy.
(17) To have crossed that line would, as Richard Tait and his sub-committee said clearly, amount to a very serious threat to the BBC's independence.
(18) Tait Coles, vice-principal, Dixons city academy, Bradford Facebook Twitter Pinterest Tait Coles If students asked me, I would turn the question around and ask them what they’d do.
(19) Taite has close-cropped grey hair, a goatee and a pair of black-rimmed glasses that automatically tint when he walks out into the southern California sunshine.
(20) It won the James Tait Black Prize, but was still received by some critics as almost hurtfully factual: the tone snappish, the refusal to flirt with the reader's expectations of personality taken as a snub.