(1) Maternal alloimmunization against fetal platelets can cause fetal and neonatal thrombocytopenia (NAIT).
(2) Improvements in antenatal diagnosis and in utero therapy facilitate appropriate management of pregnancy at risk for NAIT.
(3) There is evidence that in certain cases antibodies against blood group antigens A or B may cause NAIT.
(4) Recent evidence that NAIT is more common than has previously been recognised, a better understanding of the molecular basis of platelet serology and advances in technology, which have made it possible to take blood samples from fetuses and transfuse them in utero, have all contributed to a growing interest in this condition.
(5) Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus.
(6) Neonatal alloimmune thrombocytopenia (NAIT) occurs when maternal alloantibodies to antigens present on fetal platelets cause their immune destruction resulting in thrombocytopenia in the newborn infant or fetus.
(7) Neonatal alloimmune thrombocytopenia (NAIT) is due to fetomaternal incompatibility for platelet specific antigens, most frequently HPA-1a (PLA1) and HPA-5b (BRa).
(8) A 31 year old woman was assessed following delivery of her second child affected by neonatal alloimmune thrombocytopenia (NAIT).
(9) An immune response to human platelet antigens (HPA), as in neonatal alloimmune thrombocytopenia (NAIT) and post-transfusion purpura (PTP), is the exception rather than the rule and evidence is accumulating for the importance of human leucocyte antigen (HLA) class II restriction in this situation.
(10) This report of an unaffected pregnancy in a woman with a history of previous pregnancies complicated by NAIT illustrates the role of paternal and fetal platelet phenotyping in managing existing pregnancies at risk of NAIT.
(11) The sera of 219 Zwa-positive mothers who gave birth to children with clinically suspected neonatal alloimmune thrombocytopenia (NAIT) were tested for platelet-reactive antibodies using the platelet adhesion immunofluorescence test and a glycoprotein-specific immunoassay (MAIPA).
(12) Because there is high risk that subsequent pregnancies might be also affected by NAIT, the mothers of a previously affected child should be managed similarly to the HPA-1b mothers (PIA2, Zwb).
(13) Platelet specific alloantibodies cause neonatal alloimmune thrombocytopenia (NAIT), posttransfusion purpura (PTP) and may be found in patients who are refractory to HLA-matched platelet transfusion.
(14) In accordance with established criteria, the Sra antigen represents the first example of a "private" platelet alloantigen that bears significance in rare instances of NAIT.
(15) We report our experience with the serological diagnosis of 14 NAIT cases using new performing techniques such as western blotting (WB) and MAIPA (monoclonal antibody specific immobilization of platelet antigens).
(16) This is a report of 39 cases of NAIT involving the HPA-5b antigen.
(17) Bra antibodies were from mothers of children with neonatal alloimmune thrombocytopenia (NAIT), and anti-Brb was found in the serum of a polytransfused patient.
(18) NAIT is mainly due to alloimmunization; the frequency varying among ethnic groups.
(19) Immunization against these alloantigens is implicated in NAIT and poly-transfused patients.
(20) In the serum of a mother who gave birth to a child with the typical clinical picture of NAIT we found an antibody directed against the new platelet antigen Sra.
Trim
Definition:
(v. t.) To make trim; to put in due order for any purpose; to make right, neat, or pleasing; to adjust.
(v. t.) To dress; to decorate; to adorn; to invest; to embellish; as, to trim a hat.
(v. t.) To make ready or right by cutting or shortening; to clip or lop; to curtail; as, to trim the hair; to trim a tree.
(v. t.) To dress, as timber; to make smooth.
(v. t.) To adjust, as a ship, by arranging the cargo, or disposing the weight of persons or goods, so equally on each side of the center and at each end, that she shall sit well on the water and sail well; as, to trim a ship, or a boat.
(v. t.) To arrange in due order for sailing; as, to trim the sails.
(v. t.) To rebuke; to reprove; also, to beat.
(v. i.) To balance; to fluctuate between parties, so as to appear to favor each.
(n.) Dress; gear; ornaments.
(n.) Order; disposition; condition; as, to be in good trim.
(n.) The state of a ship or her cargo, ballast, masts, etc., by which she is well prepared for sailing.
(n.) The lighter woodwork in the interior of a building; especially, that used around openings, generally in the form of a molded architrave, to protect the plastering at those points.
(v. t.) Fitly adjusted; being in good order., or made ready for service or use; firm; compact; snug; neat; fair; as, the ship is trim, or trim built; everything about the man is trim; a person is trim when his body is well shaped and firm; his dress is trim when it fits closely to his body, and appears tight and snug; a man or a soldier is trim when he stands erect.
Example Sentences:
(1) Analysts have trimmed their profit forecasts for this year with trading profits of £3.3bn pencilled in compared with £3.5bn in 2012-13.
(2) The three rooms are plush and contemporary with tartan trim.
(3) Castanospermine (Cas), an inhibitor of alpha-glucosidase I, blocks "trimming" of the N-linked oligosaccharide Glc3Man9GlcNAc2, thus preventing normal glycoprotein maturation.
(4) The shredded fibres were trimmed in most cases and this allowed better definition of the amount of ligament considered to be torn.
(5) The carboxymethyl cellulose block was trimmed and a piece of copy paper was attached to the surface of the block with cellulose tape.
(6) Taylor, a sixty-something man with a neatly trimmed beard and a palpable pride in his business, has made "a couple of small sales" so far today, but footfall in the town is pretty underwhelming, and, in the market, almost non-existent.
(7) Asda and Morrisons have already shed thousands of staff by trimming management jobs in stores and behind the scenes.
(8) Likewise, a neoplasm may regrow locally or metastasize if a surgical border infiltrated with neoplastic cells is falsely assumed to be an artifactual trimming border.
(9) However, trimmed hams and loins from the 20-ppm RAC treatment represented a greater (P less than .05) percentage of carcass weight than did those from control animals.
(10) Players were warned before this year's tournament that officials would be rigorously enforcing its rules on "almost entirely white" clothing – meaning that the bright underwear, coloured soles and conspicuously contrasting trim spotted in previous years would be outlawed.
(11) It is suggested that C-terminal trimming of Lb to produce Lb' results in an increase in negative charge and is responsible for its slower migration in SDS-PAGE.
(12) The report of the inquiry, which helped bring down the Irish government of the day, found fraud and serious illegality in Goodman's companies in the 1980s that had involved not just the faking of documents, but also the commissioning of bogus official stamps, including those of other countries, to misclassify carcasses; passing off of inferior beef trimmings as higher-grade meat; cheating of customs officers; and institutionalised tax evasion.
(13) This difference was abrogated when the precursors were treated with glycopeptidase F. In the intracellular small chain a difference was observed in the size of carbohydrate chains that were cleavable with endo-beta-N-acetylglucosaminidase H. Sequence analysis of the N-termini of mature intracellular cathepsin D indicated a N-terminal trimming in both large and small chains from both human and transfected hamster cells.
(14) Forced four-variable regression equations were used to predict the percentage (chilled carcass weight basis) yield of boneless subprimals at the three fat trim levels as influenced by sex class, frame size, muscle score, and adjusted 12th-rib fat thickness.
(15) In the second trial 24 grafts without velours trimming (Cooley II, Meadox), 24 grafts manufactured by a new warp-knitting procedure without velours trimming (Protegraft 2000, B. Braun AG) and 24 identical grafts of B. Braun AG but with gelatine impregnation were evaluated.
(16) Strain effects were noted in rate of feed consumption following beak trimming.
(17) Serves 4 100g butter, at room temperature 150g flour 50g ground almonds 30g suet 1 egg yolk 50g cooked chestnuts, chopped 5 tbsp chopped fresh thyme Salt and black pepper For the leeks 1kg leeks, trimmed 100g butter Salt and pepper 200ml double cream 1 tsp nutmeg 1 To make the crumble topping, work the butter into the flour until it resembles coarse breadcrumbs, then add the ground almonds and suet.
(18) The results showed that Kind had a slight color change delta E* = -1.72, Trim demonstrated the most color change delta E* = -13.84, while the remaining resins demonstrated a noticeable change in color due to in vitro aging.
(19) 400g cooked or tinned butterbeans 1 tsp ground cumin 10ml lemon juice ¼ clove garlic, peeled and finely minced 1 small handful picked flat-leaf parsley, finely chopped 1 tbsp plain flour (gluten-free flour also works fine) 1 tsp salt 1 egg 1 spring onion, trimmed and finely sliced 50g breadcrumbs 100g feta (or other crumbly goat's or sheep's cheese) Put the butterbeans, cumin, lemon juice, garlic, parsley, flour, salt and egg in a food processor and blitz to a coarse paste: you don't want the mix fully pureed, otherwise the burgers will be too wet and will fall apart on the grill.
(20) Examples are provided of one-, two- and three-cycle trimmings.