(1) Neonatal alloimmune thrombocytopenic purpura (NAITP) is induced by maternal antibodies to fetal platelet alloantigens.
(2) They review the platelet antigen systems involved in NAITP and raise the problem of its present antenatal and postnatal management.
(3) This antigen is considered to be a product of an allele of the Yuk gene, another allele of which codes for Yuka which was involved in 2 cases of NAITP.
(4) anti-HLA-A24+B51 and anti-HLA-Bw61+Cw3, respectively, were detected in the mother's sera, which reacted to each patient's lymphocytes and were presumed to have been contribute to NAITP.
(5) Antibodies to the platelet HPA-1a antigen can elicit in the newborn a condition known as neonatal alloimmune thrombocytopenic purpura (NAITP).
(6) The case report emphasises that in patients with NAITP intracranial haemorrhage may occur in utero and during the perinatal period as well.
(7) Furthermore, in a review from the currently available literature the following items will be discussed: 1) human platelet antigens involved in NAITP, 2) clinical aspects and prognosis of NAITP, 3) immunological diagnosis of NAITP, and 4) prevention and treatment of the disease.
(8) We propose further study to determine if this is specific for the antepartum diagnosis of NAITP.
(9) Here reported are two cases with neonatal alloimmune thrombocytopenia (NAITP).
(10) However, the strongest association both in mothers of NAITP patients and in PTP patients was observed with the supertypic DRw52 antigen.
(11) On the other hand, some NAITP cases may have been overlooked because of their mildness.
(12) The only mother who was delivered of a child with clinical NAITP was the woman with anti-Zwa(PIA1) in serum.
(13) Sensitive assays of maternal platelet alloantibody are now available, but they lack specificity for NAITP affecting the current gestation.
(14) The authors report a case of two siblings who developed a neonatal alloimmune thrombocytopenia (NAITP) due to Bak-System incompatibility.
(15) We report a new platelet antigen (Yukb) involved in a case of neonatal alloimmune thrombocytopenia (NAITP).
(16) We demonstrate the sonographic and computer-tomographic findings in a newborn with neonatal alloimmune thrombocytopenia (NAITP).
(17) The strong association between HLA-DR3 and Zwa alloimmunization in Zwa-negative mothers, resulting in the production of anti-Zwa antibodies and ultimately in neonatal alloimmune thrombocytopenic purpura (NAITP) in the newborn, could be confirmed.
(18) We reviewed 58 literature reports of neonatal alloimmune thrombocytopenic purpura (NAITP).
Newborn
Definition:
(a.) Recently born.
Example Sentences:
(1) The newborn with critical AS typically presents with severe cardiac failure and the infant with moderate failure, whereas children may be asymptomatic.
(2) Titre in newborn was as a rule lower than the corresponding titre of mother.
(3) Blocks of hippocampal tissue containing the fascia dentata were taken from late embryonic and newborn rats and transplanted to the hippocampal region of other newborn and young adult rats.
(4) No respiratory-distress syndrome of the newborn occurred when total amniotic-fluid cortisol was greater than 60 ng per milliliter (16 patients).
(5) We have studied 166 healthy children (36 newborn infants, 34 infants aged 1-12 months, 15 aged 1-2 years, 15 children aged 2-4 years, 11 aged 4-6 years and 55 aged 6-12 years); 20 adults were also examined.
(6) Organ distribution of the 99mTc-S-colloid showed marked phagocytic activity of the liver in all age groups including the newborn period.
(7) We also demonstrated a significant difference in the Hb switching process between male and female newborns.
(8) The appearance of unusual isoenzyme patterns in newborn infants and in pregnant women in comparison with normal adults.
(9) This study demonstrates conclusively that both renin and Ao genes are expressed in the newborn kidney, providing evidence for a local renin-angiotensin system that is subjected to developmental changes.
(10) A newborn presenting with persistent umbilical stump bleeding should be screened for factor XIII deficiency when routine coagulation tests prove normal.
(11) The acetylcarnitine content of tracheal fluid was higher in samples obtained from premature newborns.
(12) These data demonstrate that 1) the pericardium increases ventricular interaction in both preterm and newborn lambs and 2) the relative percentage increase is similar for both age groups and not age dependent.
(13) Combined study of lungs of 85 foetuses and newborns of various gestational age and 8 newborns dying during the first month of life showed the lung surfactant (LS) system to develop in parallel with formation of respiratory parts and lung capillary network.
(14) Though the problems associated with Robin sequence may be numerous, especially if the primary cause of the sequence is a multiple anomaly syndrome, the most acute problems in affected newborns is upper airway obstruction.
(15) The perinatal development of the levator ani (LA) muscle in male and female rats was investigated by measuring the total number of muscle units (MU) (i.e., mononucleate cells, clustered or independent myotubes, and muscle fibers) in transverse semithin sections of the entire muscle and the MU cross-sectional area in 22-day-old fetuses (F22), 1-day-old (D1 = day of birth), 3-day-old (D3), and 6-day-old (D6) newborns.
(16) This was achieved by immunizing 91% of all newborns, 83% of children in their first year of school, and 98% of those in their final year.
(17) The major lipase in human milk is dependent on bile salts for activity and probably participates in intestinal digestion of milk lipids in the newborn.
(18) There was a remarkable tendency to newborns weighting more than 2000 g and a duration of pregnancy longer than 35 weeks.
(19) Sleep alterations in addicted newborns could be related to central nervous system (CNS) distress caused by withdrawal.
(20) Between-group responsivity differences suggest developmental retardation in term (38-42 weeks) SGA newborns, but the faster SGA latencies may reflect 'induced' acceleration in auditory neurophysiologic function.