(superl.) Characterized by obcenity; indecent; indelicate; gross; filthy.
Example Sentences:
(1) How does it stack up against the competition – and are there any nasties in the small print?
(2) Admirably, Clinton kept her cool throughout, particularly Trump when spoke over her to call her “such a nasty woman”.
(3) He wanted to stay on longer than the traditional retirement age but became involved in a nasty spat with the then-chairman, Peter Sutherland.
(4) It is the latest attack on the government from the Hungarian economist, whose previous criticism of David Cameron's "nasty" looking restrictions on benefits for foreigners led the angry prime minister to lodge a formal complaint.
(5) Protesters waved banners with slogans such as “Special relationship, just say no” and “Nasty women unite”.
(6) The examples I have quoted are the tip of a very large and very nasty iceberg.
(7) In short, it is alleged that under his rule Sri Lanka is becoming a nasty, authoritarian quasi-rogue banana republic.
(8) Patterson agrees that it’s all much more controlled now, but she also wonders whether at times the media can be too negative, doomy, and sometimes downright nasty.
(9) And I’m sorry, that will come before any internal party-political issue and I think I should be able to adopt that position without being attacked, without being subject to a nasty troll-form of politics.” On Tuesday the prime minister, David Cameron, promised to publish a comprehensive strategy on Syria in the form of a written response to a report by the foreign affairs select committee, which concluded that the government had failed to make the case for extending airstrikes.
(10) Al-Azhar, the Sunni Muslim world’s leading centre of Islamic learning, called on Muslims to “ignore the nasty frivolity” of the latest edition.
(11) He was followed by Theresa May, who 13 years ago had warned that many voters thought the Conservatives were the “nasty party”, but who now pledged to clamp down on the rights of asylum seekers, and renewed her commitment to cut net migration to below 100,000 in terms so harsh that she was widely condemned even by her allies.
(12) I think it probably gave me a sense of self and self-protection that has been very useful, and I possibly have had less nasty moments than a lot of other women.
(13) Dr Rosemary Gillespie was the object of a “nasty, vindictive and sustained campaign of bullying” from her second day in the job at the UK’s biggest HIV charity, the tribunal heard.
(14) It had a “flat, nasty” ring to it, she says, which she has since “analysed like a Rubik’s cube; I have turned it every which way.
(15) Updated at 2.10pm BST 1.47pm BST Over to America, where the latest productivity figures confirm that the US economy took a nasty jolt over the winter, when bad weather gripped the country.
(16) It doesn't have to be bloody, it doesn't have to be nasty, but it does have to be fought."
(17) That was the one surprise in the budget – apart from the fine print of the nasties.
(18) Because the nastiness on our doorstep has piled too high for too long, and I just want to get out of the house.
(19) Southampton 3-0 Vitesse | Europa League third qualifying round match report Read more Even more damagingly for West Ham, they lost Enner Valencia to a potentially nasty knee injury in the first half after he caught his leg in the turf.
(20) They orginally had lofty ambitions of talking about the economy but since they have lost that argument so catastrophically, they have reached for the Ukip playbook to create fictitious stories to scare people about immigrants and release video nasties about Turkish people”.
Tight
Definition:
() of Tie
() p. p. of Tie.
(superl.) Firmly held together; compact; not loose or open; as, tight cloth; a tight knot.
(superl.) Close, so as not to admit the passage of a liquid or other fluid; not leaky; as, a tight ship; a tight cask; a tight room; -- often used in this sense as the second member of a compound; as, water-tight; air-tight.
(superl.) Fitting close, or too close, to the body; as, a tight coat or other garment.
(superl.) Not ragged; whole; neat; tidy.
(superl.) Close; parsimonious; saving; as, a man tight in his dealings.
(superl.) Not slack or loose; firmly stretched; taut; -- applied to a rope, chain, or the like, extended or stretched out.
(superl.) Handy; adroit; brisk.
(superl.) Somewhat intoxicated; tipsy.
(superl.) Pressing; stringent; not easy; firmly held; dear; -- said of money or the money market. Cf. Easy, 7.
(v. t.) To tighten.
Example Sentences:
(1) Freshly isolated sarcoplasmic reticulum vesicles contain 0.05 mol of tightly bound ADP and 0.03 mol of tightly bound ATP per mol of Ca2+, Mg2+-ATPase (ATP phosphohydrolase, EC 3.6.1.3).
(2) The expression of the Pgp isoforms appears to be tightly regulated and, at least in some cells, under complex hormonal control.
(3) Whereas the tight junctions of endoneurial capillaries are known to prevent certain blood-borne substances from entering the endoneurium, it was not clear whether the permeability of the pulpal capillaries, which are distant from the nerve fibres, could affect the nerve fibre environment.
(4) The cells are predominantly monopolar, tightly packed, and are flattened at the outer border of the ring.
(5) These data indicate that topoisomerase I and RNA polymerase I are tightly complexed both in vivo and in vitro, and suggest a role for DNA topoisomerase I in the transcription of ribosomal genes.
(6) Immunofluorescence and immunoelectronmicroscopy experiments demonstrated that while tight junctions demarcate PAS-O distribution in confluent cultures, apical polarity could be established at low culture densities when cells could not form tight junctions with neighboring cells.
(7) Investigations have been made to determine the identity and binding characteristics of the pterins that are bound tightly to dihydrofolate reductases which are isolated from vertebrate sources by a well established procedure.
(8) At all times, a tight inverse correlation exists between ATP and IMP concentrations.
(9) Recently, a gene for ITD (DYT1) in a non-Jewish kindred was located on chromosome 9q32-34, with tight linkage to the gene encoding gelsolin (GSN).
(10) This study investigates the use of the incentive inspirometer to observe the effects of tight versus loose clothing on inhalation volume with 17 volunteer subjects.
(11) In contrast, interchange of the histones and tightly bound non-histone protein DNA complexes from hormone-withdrawn and estrogen-stimulated chromatins during reconstitution did not affect the level of mRNAOV sequences produced.
(12) Using microelectrodes and various microscopic techniques active Na+ absorption as well as K+ secretion has been localized to the principal cells, while Cl- absorption was found to proceed largely, though not exclusively, through the tight junctions between cells.
(13) The successful establishment of a postcrisis SV-40 T antigen transformed epithelial cell line, 1HAEo-, which retains tight junctions and vectorial ion transport, is described.
(14) The present investigation shows that the intramembranous proteins of tight and gap junctions are mobile structures within the fluid membrane.
(15) In contrast, after incubation with 0.5% DOC, the core microfilaments are no longer tightly bundled yet the lateral arms remain attached with a distinct 33-nm periodicity.
(16) The data collected by several approaches reveal that assembly and maturation of vaccinia involves a tightly coupled sequence of interrelated events including the assembly of the envelope, post-translational cleavage of several virion polypeptides, and induction of the core enzymes.
(17) The tight coupling between neuronal activity and oxidative energy metabolism forms the basis for the use of cytochrome oxidase as an endogenous metabolic marker for neurons.
(18) When using a nylon thread for the attachment of a pseudophakos to the iris, it may happen that the suture is slung tightly around the implant-lens.
(19) Some antibodies and other proteins bind tightly to nitrocellulose and dissociation of these proteins by Tween 20 is barely detectable.
(20) Independent experts warn that rumours and deliberate misinformation about the regime are rife, partly because it is impossible to verify or disprove most stories about the tightly controlled country's elite.