(v. t.) To make necessary or indispensable; to render unaviolable.
(v. t.) To reduce to the necessity of; to force; to compel.
Example Sentences:
(1) Rapid overgrowth of all cultures with the E. coli necessitated the use of selective media containing antimicrobial agents to which the E. coli was sensitive.
(2) There were two postoperative stomal prolapses, one of which necessitated reoperation.
(3) Since the early 1960's nasotracheal tubes have been used for neonates with primary respiratory diseases which necessitated positive pressure ventilation.
(4) The presence of vital and sensitive organs such as the spinal cord, heart, and lungs makes curative radiotherapy of non-small cell lung cancer difficult to implement and necessitates use of oblique portals.
(5) An epidemiological survey carried out in 460 public and private institutions chosen at random country-wide in France made it possible to study injuries whose treatment had necessitated an anaesthetic.
(6) Judging from available clinical studies, surgical fusion operations may be useful in properly selected patients with spondylolisthesis or in situations for which the surgical approach has necessitated destabilization by laminectomy and facetectomy.
(7) Side effects of carbenoxolone therapy were observed, but they did not necessitate withdrawal of the drug and were readily controlled in every instance.
(8) The presence of severe pulmonary disease is the critical factor that might necessitate a staged repair.
(9) The influence of preanalytical factors such as food intake, posture, use of tourniquet and freezing and storing samples is great and necessitates standardisation of specimen collection.
(10) In the others, serum PTH remained elevated and subsequent symptomatic hypercalcaemia necessitated parathyroidectomy.
(11) Shaping and fine working of restorations necessitated by cervical lesions, abrasions at the necks of teeth, or root surface caries can often be arduous to complete.
(12) The surgical removal of branchiomeric paragangliomas necessitates preparation of a small saphenous vein bypass in case it is not possible to avoid sacrificing the internal carotid artery.
(13) Two patients had mild pancreatitis, which necessitated endoscopic sphincterotomy in one.
(14) Reoperation was more frequent after valve replacement with bioprostheses (6.7% per patient year) than after valvuloplasty (4.3% per patient year) and after mechanical valve replacement (1.5% per patient year; P less than 0.02), and was necessitated mainly by residual or recurrent valve dysfunction after valvuloplasty, bland or infected periprosthetic leaks in mechanical valves and degradation of bioprostheses.
(15) Estimation of pairwise connectivity is the most common method of determining the neural 'network' but usually necessitates the production of numerous histograms for each pair considered.
(16) These lesions might necessitate further surgical treatment as possibly total joint prosthesis.
(17) The diagnostic criteria of potentially fatal asthma included at least one of the following four potentially fatal asthma events: 1) mechanical ventilation for respiratory arrest or failure, 2) acute respiratory acidosis that did not necessitate mechanical ventilation, 3) two episodes of acute pneumomediastinum or pneumothorax associated with status asthmaticus, 4) two or more hospitalizations for status asthmaticus in spite of long term oral corticosteroids.
(18) The recent discovery of the existence of a second mouse TSP gene necessitates careful examination of the discrete biochemical and functional properties associated with each molecule.
(19) Thirteen cases were considered medical treatment failures, and 11 necessitated therapeutic surgery.
(20) The classic scoliosis was resistant to brace treatment; bracing failed in 70% of patients, necessitating spinal fusion.
Stimulate
Definition:
(v. t.) To excite as if with a goad; to excite, rouse, or animate, to action or more vigorous exertion by some pungent motive or by persuasion; as, to stimulate one by the hope of reward, or by the prospect of glory.
(v. t.) To excite; to irritate; especially, to excite the activity of (a nerve or an irritable muscle), as by electricity.
Example Sentences:
(1) Stimulation of human leukocytes with various chemical mediators such as TPA, f-Met-Leu-Phe, LTB4, etc.
(2) The optimal size for stimulation was between 5 degrees and 12 degrees (visual angle).
(3) After stimulation with lipopolysaccharide and calcium ionophore A23187, culture supernatants of clones c18A and c29A showed cytotoxic activity against human melanoma A375 Met-Mix and other cell lines which were resistant to the tumor necrosis factor, lymphotoxin and interleukin 1.
(4) Apparently, the irradiation with visible light of a low intensity creates an additional proton gradient and thus stimulates a new replication and division cycle in the population of cells whose membranes do not have delta pH necessary for the initiation of these processes.
(5) In conclusion, in S-rats a glucose-stimulated insulin release is accompanied by an increase in IBF, but this is not observed in P-rats.
(6) Stimulation is also observed with mixtures of APC expressing DPw3 and APC expressing A1, and likewise, DPw3+ APC become stimulatory when preincubated with supernatants from A1-positive cells.
(7) We have previously shown that serotonin is present in secretory granules of frog adrenochromaffin cells; concurrently, we have demonstrated that serotonin is a potent stimulator of corticosterone and aldosterone secretion by adrenocortical cells.
(8) Cyclic AMP stimulated phosphorylation by [gamma-32P]ATP of two proteins of apparent Mr = 20,000 and 7,000 that were concentrated in sarcoplasmic reticulum, but the stimulation was markedly dependent on the presence of added soluble cyclic AMP-dependent protein kinase.
(9) We have investigated a physiological role of endogenous insulin on exocrine pancreatic secretion stimulated by a liquid meal as well as exogenous secretin and cholecystokinin octapeptide (CCK-8) in conscious rats.
(10) Whether hen's egg yolk can be used as a sperm motility stimulant in the treatment of such conditions as asthenospermia and oligospermia is subjected for further study.
(11) Some of those drugs are able to stimulate the macrophages, even in an aspecific way, via the gut associated lymphatic tissue (GALT), that is in connection with the bronchial associated lymphatic tissue (BALT).
(12) The results also suggest that the dispersed condition of pigment in the melanophores represents the "resting state" of the melanophores when they are under no stimulation.
(13) dl-Methionine stimulated the synthesis of cephalosporins when added after the growth phase.
(14) Bradykinin also stimulated arachidonic acid release in decidual fibroblasts, an effect which was potentiated in the presence of epidermal growth factor (EGF), but which was not accompanied by an increase in PGF2 alpha production.
(15) Pokeweed mitogen-stimulated rat spleen cells were identified as a reliable source of rat burst-promoting activity (PBA), which permitted development of a reproducible assay for rat bone marrow erythroid burst-forming units (BFU-E).
(16) To investigate the mechanism of enhanced responsiveness of cholesterol-enriched human platelets, we compared stimulation by surface-membrane-receptor (thrombin) and post-receptor (AlF4-) G-protein-directed pathways.
(17) Estimates of potential for gastrointestinal side effects using the rat enteropooling assay and in vivo monkey effects indicate that diarrhea will be substantially reduced with retention of uterine stimulating potency.
(18) Because it has been suggested that the lathyrogen, BAPN, may stimulate the release of proteases, the protease inhibitors Trasylol and epsilon-aminocaproic acid (EACA) were given alone or in combination to BAPN-treated rats.
(19) The present study was designed to test the hypothesis that the decreased Epi response following ET was due to 1) depletion of adrenal Epi content such that adrenomedullary stimulation would not release Epi, 2) decreased Epi release with direct stimulation, i.e., desensitization of release, or 3) decreased afferent signals generated by ET itself.
(20) Stimulation of atrial H1-receptors is suggested to directly cause an increase in Ca-channel conductance independent of intracellular cAMP content.