(1) However, an anti-nef antibody response was also seen in 5 of 93 (5%) nonrisk dermatological patients and in 4 of 37 (11%) healthy blood donors.
(2) Plasma was analyzed for NEF and 3 metabolites [hydroxynefazodone (HO-NEF), m-chlorophenylpiperazine (mCPP) and p-hydroxynefazodone (p-HO-NEF)] by a validated HPLC assay.
(3) We found that HIV Nef shares sequence and structural features with scorpion peptides known to interact with K+ channels.
(4) These observations were confirmed by in vitro experiments using purified NeFs.
(5) DEAE-transfection of viral DNA containing an open from of nef yielded virus that replicated with similar kinetics and to a similar extent in macaque peripheral blood lymphocyte (PBL) cultures as virus with a deletion or stop codon within nef.
(6) Complement-independent binding of C3 nephritic factor (NEF) to sheep erythrocytes was observed in heat-inactivated sera from patients having this autoantibody.
(7) In 31 of the sera, the specificity of anti-nef antibodies was further analysed by enzyme-linked immunosorbent assay (ELISA) with large synthetic peptides ranging from 31 to 66 amino acid residues and spanning the total sequence of nef from HIV-1.
(8) Human T-lymphocytic cell line H9 infected with the HTLV-IIIB isolate of human immunodeficiency virus type 1 (HIV-1) synthesizes two forms of the Nef protein (p25 and p27) that differ both in molecular weight and charge.
(9) The recombinant Nef protein was purified to near homogeneity by DEAE-Sephacel, phenyl-Sepharose 4B, blue-Sepharose, and Sephadex G-150 column chromatography.
(10) Earlier studies indicated nef to be a negative regulatory factor for viral transcription, whereas more recent studies report evidence against this original hypothesis.
(11) Absence of anti-nef antibodies was associated with symptomatic HIV infection.
(12) The effects of Nef on the transmembrane potential were studied in rabbit sinoatrial nodes and the clusters of cultured cardiac myocytes from neonatal rats.
(13) The type 1 human immunodeficiency virus (HIV-1) encodes a 27-kDa protein termed Nef (negative factor).
(14) Surprisingly, CTL specific for regulatory, non-structural nef protein appear to be a major constituent of the human immune response to HIV.
(15) Determination of the B-cell epitopes of the nef molecule encoded by the human immunodeficiency virus type 1 (HIV-1) was undertaken using a set of six synthetic peptides.
(16) In contrast, the extent and the appearance of nef-specific antibodies during the course of infection varied considerably between individual animals.
(17) The functions of yet other viral genes (nef, vpt) remain unclear.
(18) All of these anti-nef positive sera also contained antibodies directed against viral structural proteins.
(19) The results showed that the vascular selectivity values of Ver, Nef, and Tet were 1.15, 0.32, and 0.20, respectively in WKY and 0.80, 0.24, and 0.10, respectively in SHR.
(20) Recombinant antigens containing all or parts of the HIV-1 proteins p24, Nef and gp41 and HIV-2 gp36 have been purified and used to develop a rapid immunoassay to detect and differentiate between HIV-1 and HIV-2 antibodies in a single test.
Renaissance
Definition:
(n.) A new birth, or revival.
(n.) The transitional movement in Europe, marked by the revival of classical learning and art in Italy in the 15th century, and the similar revival following in other countries.
(n.) The style of art which prevailed at this epoch.
Example Sentences:
(1) Over the past decade, the quinolone antimicrobial class has enjoyed a renaissance with the emergence of the fluoroquinolone subclass.
(2) Spanish renaissance In contrast, Spanish has held up remarkably well, due to its resilience at GCSE and growing awareness of the number of people around the world who speak it.
(3) In ancient Rome and during the Renaissance compression by means of leaden plates was a well-known treatment of cancer.
(4) The facial appearance is similar to a Renaissance cherub with its gaze toward heaven.
(5) It will also star Tony Hale, known for his hapless characters in Arrested Development and Veep, and Natasha Lyonne, currently enjoying a career renaissance for her role in Netflix series Orange is the New Black.
(6) Such myths were transformed by Renaissance artists such as Titian into alluring sensual painting.
(7) Arthur Koestler in The Act of Creation expresses it thus: "From the Pythagoreans onward, through the Renaissance to our times, the oceanic feeling, the sense of participation in the mystery of the infinite, was the principal inspiration of the wingèd and flat-footed creature, the scientist."
(8) Next to an ornate Renaissance gate, the hall where the "English comedians" first acted still stands.
(9) The movement is part of the current feminist renaissance.
(10) No representative from the Scottish National party, which has placed a moratorium on fracking, had accepted Ineos’s invitation to attend the ceremony marking the renaissance of one of Scotland’s largest employers.
(11) The coalition's much-touted manufacturing renaissance is so far confined to a roundabout of hi-tech firms in east London, and British industry remains largely a bit-player, making and assembling parts for foreign companies.
(12) That's why Italians talk as though they're singing lovely operatic arias and had a Renaissance, while in Finland conversations so often go like this – First lugubrious man: "This beer's good."
(13) It does feel like British chocolate is making a renaissance after being in the doldrums for a few decades.” As well as its network of shops, Hotel Chocolat owns a cocoa plantation on St Lucia, which is home to a luxury hotel where a two-week stay costs up to £10,000.
(14) Such pitfalls of political art in the era of Hitler and Stalin help to explain why the greatest, most perceptive work of art of the 30s – not to mention the 20th century – was made by a man who up to then had seemed more interested in sex, sun and the destruction of Renaissance perspective than the urgent affairs of the day.
(15) For three days at the end of January, the Renaissance hotel in Washington DC fills up with television executives from around the world.
(16) It’s the start of a French renaissance, and I hope a European one.” He said he wanted to bring back ambition and “not play on fears but transform them into energy”.
(17) A survey by Renaissance Capital found that nearly half of the country's middle class (defined as an average monthly income of $500-$600) were planning to buy fridges, freezers and other white goods, "suggesting a consumer boom is under way".
(18) Writing in the Observer , Rogers, whose architectural partnership designed the Millennium Dome and the National Assembly of Wales, states that the “brilliant garden bridge will enhance our public realm and reconnect the city, strengthening London’s renaissance, celebrating the river, creating an oasis of calm and beauty, and opening up new perspectives on London”.
(19) Instead, western Ukrainian nationalism meets support as 'national renaissance' from pundits like Timothy Snyder and Anne Applebaum.
(20) Late Renaissance – no good.” Facebook Twitter Pinterest 'The organic nature of the city is just incredible' ... Kowloon was merged with the main Hong Kong island for the 2012 game Sleeping Dogs.