(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Net
Definition:
(v. t.) To make into a net; to make n the style of network; as, to net silk.
(v. t.) To take in a net; to capture by stratagem or wile.
(v. t.) To inclose or cover with a net; as, to net a tree.
(v. i.) To form network or netting; to knit.
(a.) Without spot; pure; shining.
(a.) Free from extraneous substances; pure; unadulterated; neat; as, net wine, etc.
(a.) Not including superfluous, incidental, or foreign matter, as boxes, coverings, wraps, etc.; free from charges, deductions, etc; as, net profit; net income; net weight, etc.
(v. t.) To produce or gain as clear profit; as, he netted a thousand dollars by the operation.
Example Sentences:
(1) Manometric studies with resting cells obtained by growth on each of these sulfur sources yielded net oxygen uptake for all substrates except sulfite and dithionate.
(2) M NET is currently installed in referring physician office sites across the state, with additional physician sites identified and program enhancements under development.
(3) External exposures to a contaminated fishing net and fishing boat are considered pathways for fishermen.
(4) If tracer is introduced into the carotid artery after osmotic treatment, brain uptake is increased by a net factor of 50 (a factor of 70 due to elevation of PA, multiplied by 7 due to infusion by the carotid route) as compared to uptake by normal, untreated brain with infusion into a peripheral vein.
(5) Short incubations with heparin (5 min) caused a release of the enzyme into the media, while longer incubations caused a 2-8-fold increase in net lipoprotein lipase secretion which was maximal after 2-16 h depending on cell type, and persisted for 24 h. The effect of heparin was dose-dependent and specific (it was not duplicated by other glycosaminoglycans).
(6) Only those derivatives with a free amino group and net positive charge in the side chain were effective.
(7) When labelled long-chain fatty acids or glycerol were infused into the lactating goat, there was extensive transfer of radioactivity into milk in spite of the absence of net uptake of substrate by the mammary gland.
(8) PYY inhibited the reduction in net absorption of sodium chloride and water evoked by vasoactive intestinal peptide (VIP), but did not affect the VIP-evoked increase in net potassium secretion.
(9) A relative net reduction of 47% in lactose malabsorption was produced by adding food, and the peak-rise in breath H2 was delayed by 2 hours.
(10) In assessing damaged nets and curtains it must be recognised that anything less than the best vector control may have no appreciable impact on holoendemic malaria.
(11) No net hepatic uptake of glucose was observed before or after feeding.
(12) This force will be numerically similar to the net driving Starling force in small pores, but distinctly different in large pores.
(13) Increased amino acid incorporation into hepatic proteins in tumor-bearing animals and also probably in cancer patients is due to a net increased hepatic protein synthesis, probably not confined to acute-phase reactants only.
(14) In this study, protein efficiency ratio and net protein utilization together with the kinetic estimates of protein turnover were used to compare the effect of different protein and fat sources in healthy rats.
(15) Meanwhile the Brooklyn Nets, who have been dealing with nothing but bad news since the start of the regular season, will be without Paul Pierce for 2-4 weeks, also due to a right hand fracture.
(16) In the postprandial state net acid (4.9%) and sulfate (2.2%) had much less importance as determinants of calciuria.
(17) Proper maintenance of body orientation was defined to be achieved if the net angular displacement of the head-and-trunk segment was zero during the flight phase of the long jump.
(18) The authors tested their own technique, using transplants or implants of corium, fascia, dura mater and polyester net, internally in the tendons, fastening them with an external cross suture.
(19) These studies indicate that, in three models of acute liver injury, the net influx of calcium across the plasma membrane is increased early in the evolution of the injury before irreversible damage occurs.
(20) A state of net secretory fluid flux was induced in isolated jejunal loops in weanling pigs by adding theophylline or cholera toxin to the lumen of the isolated loops.