(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
New
Definition:
(superl.) Having existed, or having been made, but a short time; having originated or occured lately; having recently come into existence, or into one's possession; not early or long in being; of late origin; recent; fresh; modern; -- opposed to old, as, a new coat; a new house; a new book; a new fashion.
(superl.) Not before seen or known, although existing before; lately manifested; recently discovered; as, a new metal; a new planet; new scenes.
(superl.) Newly beginning or recurring; starting anew; now commencing; different from has been; as, a new year; a new course or direction.
(superl.) As if lately begun or made; having the state or quality of original freshness; also, changed for the better; renovated; unworn; untried; unspent; as, rest and travel made him a new man.
(superl.) Not of ancient extraction, or of a family of ancient descent; not previously kniwn or famous.
(superl.) Not habituated; not familiar; unaccustomed.
(superl.) Fresh from anything; newly come.
(adv.) Newly; recently.
(v. t. & i.) To make new; to renew.
Example Sentences:
(1) The liver metastasis was produced by intrasplenic injection of the fluid containing of KATOIII in nude mouse and new cell line was established using the cells of metastatic site.
(2) The femoral component, made of Tivanium with titanium mesh attached to it by a new process called diffusion bonding, retains superalloy fatigue strength characteristics.
(3) Apparently, the irradiation with visible light of a low intensity creates an additional proton gradient and thus stimulates a new replication and division cycle in the population of cells whose membranes do not have delta pH necessary for the initiation of these processes.
(4) If ascorbic acid was omitted from the culture medium, the extensive new connective tissue matrix was not produced.
(5) Neuropsychological testing is a relatively new field in the area of clinical neuroscience.
(6) says Gregg Wallace opening the new series of Celebrity MasterChef (Mon-Fri, 2.15pm, BBC1).
(7) A new balloon catheter has been developed for angioplasty.
(8) A new and simple method of serotyping campylobacters has been developed which utilises co-agglutination to detect the presence of heat-stable antigens.
(9) These results suggest the presence of a new antigen-antibody system for another human type C retrovirus related antigens(s) and a participation of retrovirus in autoimmune diseases.
(10) The combined analysis of pathogenesis and genetics associated with the salmonella virulence plasmids may identify new systems of bacterial virulence and the genetic basis for this virulence.
(11) The previous year, he claimed £1,415 for two new sofas, made two separate claims of £230 and £108 for new bed linen, charged £86 for a new kettle and kitchen utensils and made two separate claims, of £65 and £186, for replacement glasses and crockery.
(12) Richard Bull Woodbridge, Suffolk • Why does Britain need Chinese money to build a new atomic generator ( Letters , 20 October)?
(13) This new observation offers good possibilities to study the metabolism of tryptophan at the cellular level.
(14) Graft life is even more prolonged with patch angioplasty at venous outflow stenoses or by adding a new segment of PTFE to bypass areas of venous stenosis.
(15) Paradoxically, each tax holiday increases the need for the next, because companies start holding ever greater amounts of their tax offshore in the expectation that the next Republican government will announce a new one.
(16) Michael Schumacher’s manager hopes F1 champion ‘will be here again one day’ Read more Last year, Red Bull were frustrated by Mercedes, Ferrari and Honda as they desperately looked for a new engine supplier.
(17) The strongest predictor of non-sudden cardiac death was the New York Heart Association functional class.
(18) But RWE admitted it had often only been able to retain customers with expired contracts by offering them new deals with more favourable conditions.
(19) In the fall of 1975, 1,915 children in grades K through eight began a school-based program of supervised weekly rinsing with 0.2 percent aqueous solution of sodium fluoride in an unfluoridated community in the Finger Lakes area of upstate New York.
(20) Schneiderlin, valued at an improbable £27m, and the currently injured Jay Rodriguez are wanted by their former manager Mauricio Pochettino at Spurs, but the chairman Ralph Krueger has apparently called a halt to any more outgoings, saying: “They are part of the core that we have decided to keep at Southampton.” He added: “Jay Rodriguez and Morgan Schneiderlin are not for sale and they will be a part of our club as we enter the new season.” The new manager Ronald Koeman has begun rebuilding by bringing in Dusan Tadic and Graziano Pellè from the Dutch league and Krueger said: “We will have players coming in, we will make transfers to strengthen the squad.