(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Nip
Definition:
(n.) A sip or small draught; esp., a draught of intoxicating liquor; a dram.
(v. t.) To catch and inclose or compress tightly between two surfaces, or points which are brought together or closed; to pinch; to close in upon.
(v. t.) To remove by pinching, biting, or cutting with two meeting edges of anything; to clip.
(v. t.) Hence: To blast, as by frost; to check the growth or vigor of; to destroy.
(v. t.) To vex or pain, as by nipping; hence, to taunt.
(n.) A seizing or closing in upon; a pinching; as, in the northern seas, the nip of masses of ice.
(n.) A pinch with the nails or teeth.
(n.) A small cut, or a cutting off the end.
(n.) A blast; a killing of the ends of plants by frost.
(n.) A biting sarcasm; a taunt.
(n.) A short turn in a rope.
Example Sentences:
(1) Pupils who disrupt the learning of their classmates are dealt with firmly and, in many cases, a short suspension is an effective way of nipping bad behaviour in the bud."
(2) The intravenous hypotensive potency of NIP-121 but not cromakalim was similar to that of p.o.
(3) It is concluded that NIP and IPPV affect the SV RV and the right heart blood flow.
(4) In support of this contention, it was observed that rabbit antiserum to NP-CG, after absorption with CG-Sepharose, augmented the response of mice to standard immunization with NIP(12)-CG.
(5) Mouse spleen B lymphocytes, enriched for cells bearing anti-NIP (hapten 4-hydroxy-3-iodo-5-nitrophenylacetic acid) receptors, were pretreated briefly with NIP-POL (polymerized flagellin) antigen, washed, and added in small numbers to microcultures.
(6) It was shown that to reticular nucleus stimulation responded predominantly those VP and VL neurons (73.7% and 86.2%, respectively) which responded to stimulation of MI and n. NIP.
(7) The arming factor was neutralized by a sufficient concentration of NIP-BSA (twice the concentration causing maximal precipitation) but low concentrations (e.g., 7% of the maximal precipitation concentration) increased the arming capacity.
(8) Zone C has been defined as the cortical region projecting to the nucleus interpositus anterior (NIA) and posterior (NIP).
(9) The medial two-thirds of the nucleus interpositus posterior (NIP) project only to the medial aspect of the NRm, with no apparent organization.
(10) Attention was focussed on B lymphocytes through using hapten human gamma globulin (HGG) preparations as putative tolerogens in tissue culture, the T-cell-independent antigens DNP-POL and NIP-POL as challenge injections in adoptive hosts, and numbers of hapten-specific PFC in host spleens for the quantitation of immune competence.
(11) Retrograde transport of 3H-nipecotic acid (NIP) labeled the myelinated fibers and neurons of the medial OC system, including collateral projections to the peripheral VCN, subpeduncular granule cells, and nucleus Y. Medial and lateral OC efferent collaterals thus innervate different regions of the CN.
(12) Spleen fragments derived from NIP-CG primed mice produced more IgG anti-NIP antibodies than fragments derived from untreated mice when immunized in vitro with NIP-Ficoll.
(13) These activated T cells responded in vitro very well to the NIP-MGG complex but not to the MGG carrier alone demonstrating the requirement of the hapten for T cell stimulation.
(14) These phenotypic and genetic data confirmed that unique Nip+ L. lactis subsp.
(15) Frank Lampard had moved to nip all talk of farewells in the bud.
(16) Lochhead nips in to poke the pass out of the striker's reach.
(17) Complete resolution of NIPS occurred in only two patients, one of whom later developed Parkinson's disease.
(18) These findings suggest that the inverse association between smoking and IPD may apply to NIP.
(19) Jeremy Hunt has it in his secretary of state's power to nip this in the bud and insist that Papworth should realise its move, 10 years in the planning, to the 310-bed hospital in the Cambridge biomedical campus, next door to Addenbrooke's, where Roy Calne pioneered liver transplantation and much more.
(20) She was joint chair of a group of nearly 70 Labour MPs who last summer launched a pro-Europe campaign group, Labour Yes , in a bid to put forward a distinctive leftwing pro-European voice, and nip in the bud any suggestion that Labour support for a referendum represented a cooling of the party’s support for Europe .