(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Pitcher
Definition:
(n.) One who pitches anything, as hay, quoits, a ball, etc.; specifically (Baseball), the player who delivers the ball to the batsman.
(n.) A sort of crowbar for digging.
(n.) A wide-mouthed, deep vessel for holding liquids, with a spout or protruding lip and a handle; a water jug or jar with a large ear or handle.
(n.) A tubular or cuplike appendage or expansion of the leaves of certain plants.
Example Sentences:
(1) They could go out and trade for a pitcher such as the New York Mets’ Bartolo Colón , an obvious choice despite his 41 years, but he would come with an $11m price tag for next season and have to pass through the waiver wires process first – considering the wily mood Billy Beane is in this year, the A’s could be the team that blocks such a move.
(2) That is the question facing Major League Baseball pitchers who are faced with the horrendous looking but protective hat that made its debut this week.
(3) Runners at the corners for Daniel Descalso who he hits a hard ground ball right to Barmes at shortstop (not second base), he steps on the bag at second to get Freese for one out, fires to first to get the second out, and that's what we call an inning ending double play...or sometimes we call it a pitchers best friend.
(4) Electromyography and high-speed film were used to examine the muscle activity in the elbows of pitchers with medial collateral ligament insufficiency compared to the activity in uninjured elbows.
(5) 2.05am BST Cardinals 0 - Red Sox 0, top of the 4th We have a pitcher's duel ladies and gentlemen!
(6) Their acquisition of starting pitcher Ubaldo Jimenez however, well, that’s a wild one.
(7) When hall-of-fame pitcher Tom Glavine signed with the Mets, he agreed to build a new baby nursery in team-mate Joe McEwing’s home for his No47.
(8) 1.51am GMT Cardinals 2 - Red Sox 1, top of 5th AlisonW (@AlisonW) #RedSox finally doing what they do best: making the pitcher make more pitches.
(9) 1.06am GMT Red Sox 0 - Cardinals 0, bottom of the 3rd And Clay faces Lance Lynn to start off the third, and the Superman-character named pitcher works a decent at-bat, working the count to 2-2 and then fouling off the next two pitches and taking ball three to a full count.
(10) Matt Cain became the latest Giants All-Star pitcher to slide , joining Barry Zito , who started the trend, and Tim Lincecum, whose 4.37 ERA was rewarded with a two-year $35m deal, a curious decision from the front office.
(11) Five of the best S. flava : bright yellow trumpet pitchers and sulphur-yellow flowers.
(12) All of the pitchers returned to professional or college league baseball without recurrence of the ulcer.
(13) All four pitchers returned to professional baseball the year following surgical excision of the bursa.
(14) I will refrain on saying my thoughts on the National League and pitchers hitting, but all I'm saying here is that maybe it would have been more fun to see a David Oritz or Victor Martinez hitting there instead.
(15) The tying run is coming to the plate and a new pitcher is coming to the mound... Jon Smalldon (@jonsmalldon) Brandon Crawford!
(16) Manager Mike Scioscia may have one-time slugger Josh Hamilton back in time for the postseason, should he heal from rib inflammation ( if they even need him ); same goes for starting pitcher Matt Shoemaker, who has carried the team down the stretch and is recovering from a mild left rib-cage strain , not to mention his rookie hazing role as a Saudi oil tycoon.
(17) 1.05am BST Jake Peavy Dave Leese (@dl_1009) @Busfield @LengelDavid I especially like watching a pitcher who's been declared legally blind, have a go at hitting a 90mph fastball October 26, 2013 Yes, the Sox starter is legally blind without corrective lenses.
(18) These pitchers have had symptoms for some time with progressive loss of full extension of the elbow and increasing pain.
(19) Sox on the Beach (@SoxontheBeach) Also, why are the A's fans behind home plate waving towels when THEIR pitcher is in the mound?
(20) Even more so if "rookie" Hyun-jin Ryu doesn't get his act together tonight - the first Korean pitcher to start in the playoffs looked nothing like the impressive hurler he was in the regular season, getting hit hard by the Braves in the NLDS.