(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Record
Definition:
(v. t.) To recall to mind; to recollect; to remember; to meditate.
(v. t.) To repeat; to recite; to sing or play.
(v. t.) To preserve the memory of, by committing to writing, to printing, to inscription, or the like; to make note of; to write or enter in a book or on parchment, for the purpose of preserving authentic evidence of; to register; to enroll; as, to record the proceedings of a court; to record historical events.
(v. i.) To reflect; to ponder.
(v. i.) To sing or repeat a tune.
(v. t.) A writing by which some act or event, or a number of acts or events, is recorded; a register; as, a record of the acts of the Hebrew kings; a record of the variations of temperature during a certain time; a family record.
(v. t.) An official contemporaneous writing by which the acts of some public body, or public officer, are recorded; as, a record of city ordinances; the records of the receiver of taxes.
(v. t.) An authentic official copy of a document which has been entered in a book, or deposited in the keeping of some officer designated by law.
(v. t.) An official contemporaneous memorandum stating the proceedings of a court of justice; a judicial record.
(v. t.) The various legal papers used in a case, together with memoranda of the proceedings of the court; as, it is not permissible to allege facts not in the record.
(v. t.) Testimony; witness; attestation.
(v. t.) That which serves to perpetuate a knowledge of acts or events; a monument; a memorial.
(v. t.) That which has been, or might be, recorded; the known facts in the course, progress, or duration of anything, as in the life of a public man; as, a politician with a good or a bad record.
(v. t.) That which has been publicly achieved in any kind of competitive sport as recorded in some authoritative manner, as the time made by a winning horse in a race.
Example Sentences:
(1) Steady-state values of cell, glucose, and cellulase concentration oxygen tension, and outlet gas oxygen partial pressure were recorded.
(2) Lucy and Ed will combine coverage of hard and breaking news with a commitment to investigative journalism, which their track record so clearly demonstrates”.
(3) Microionophoretically applied excitatory amino acids induced firing of extracellularly recorded single units in a tissue slice preparation of the mouse cochlear nucleus, and the similarly applied antagonist 2-amino-5-phosphonovalerate (2APV) was demonstrated to be a selective N-methyl-D-aspartate (NMDA) receptor antagonist.
(4) The inquiry found the law enforcement agencies routinely fail to record the professions of those whose communications data records they access under Ripa.
(5) Phenotypic relationships were examined between final score and 13 type appraisal traits and first lactation milk yield from 2935 Ayrshire, 3154 Brown Swiss, 13,110 Guernsey, 50,422 Jersey, and 924 Milking Shorthorn records.
(6) Completeness of isolation of the coronary and systemic circulations was shown by the marked difference in appearance times between the reflex hypotensive responses from catecholamine injections into the isolated coronary circulation and the direct hypertensive response from a similar injection when the circulations were connected as well as by the marked difference between the pressure pulses recorded simultaneously on both sides of the aortic balloon separating the two circulations.4.
(7) Subjects then rested supine until 10.00 h when blood was again taken, and blood pressure recorded.
(8) Sewel is also recorded complaining about the level of appearance allowances at the House of Lords .
(9) A mean difference for individual patients between the first and second recording within 5 mm Hg was observed in 49.3% and 52.1% of patients for 24-hour systolic and diastolic blood pressure, respectively.
(10) In the upper limb and facial forms of familial amyloidotic polyneuropathy first recorded in Swiss and Finns respectively, the differences in their patterns of neurological disease and ocular lesions could be the result of their amyloids deriving from proteins other than prealbumin.
(11) Since 1979, patients started on long-term lithium treatment at the Psychiatric Hospital in Risskov have been followed systematically with recording of clinical and laboratory variables before the start of treatment, after 6 and 12 months of treatment, and thereafter at yearly intervals.
(12) Polygraphic recordings during sleep were performed on 18 elderly persons (age range: 64-100 years).
(13) Richard Hill, deputy chief executive at the Homes & Communities Agency , said: "As social businesses, housing associations already have a good record of re-investing their surpluses to build new homes and improve those of their existing tenants.
(14) Several dimensions of the outcome of 86 schizophrenic patients were recorded 1 year after discharge from inpatient index-treatment to complete a prospective study concerning the course of illness (rehospitalization, symptoms, employment and social contacts).
(15) Even if it were not the case that police use a variety of tricks to keep recorded crime figures low, this data would still represent an almost meaningless measure of the extent of crime in society, for the simple reason that a huge proportion of crimes (of almost all sorts) have always gone unreported.
(16) The records of 148 geriatric patients discharged from the Royal Ottawa Hospital over an 18-month period were studied.
(17) It is suitable either for brief sampling of AP durations when recording with microelectrodes, which may impale cells intermittently, or for continuous monitoring, as with suction electrodes on intact beating hearts in situ.
(18) The records of all patients treated for thymoma in the Department of Radiotherapy of the University of Torino between 1970 and 1988 were reviewed.
(19) Both of these species belong to the serotype B. MCAs T11 and T15, the first recorded with a specificity for only sub-serotype A2 EF, were tested further against 28 sub-serotype A2 and three sub-serotype A2B2EFs from L. tropica strains.
(20) The time to make the decision and the total time are automatically recorded.