(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Rep
Definition:
(n.) A fabric made of silk or wool, or of silk and wool, and having a transversely corded or ribbed surface.
(a.) Formed with a surface closely corded, or ribbed transversely; -- applied to textile fabrics of silk or wool; as, rep silk.
Example Sentences:
(1) The sequence of the rep control region was determined, and putative regulatory sequences were identified; no evidence for autoregulation of expression was obtained.
(2) This has "nothing to do with any of our businesses," Koch spokespeople were quoted as telling the congressman's staff members in a May 20 letter that Waxman sent to Reps. Fred Upton (R-Mich.), the Energy and Commerce Committee chair, and Ed Whitfield (R-Ky.), who chairs the Energy and Power Subcommittee.
(3) The results add support for the general significance of AAV-2 and specifically the rep gene as tools for down-regulating heterologous gene expression.
(4) Deletions between -94 and -153 bp relative to the p19 cap site reduced Rep induction of both the p19 and p40 promoters coordinately.
(5) Specific binding with 125I-rEp showed that 60% of the binding was inhibited by excess pure erythropoietin (Ep), but not by albumin, fetal calf serum, and a variety of growth factors or glycoproteins.
(6) The rep gene proteins of AAV type 2 (AAV2) inhibited the trans-activating ability of HIV-1.
(7) "We regret that Congress was forced to waste its time voting on a foolish bill that was premised entirely on false claims and ignorance," David Jenkins, an REP official, said in a statement.
(8) Nine out of 10 private sector workplaces have never seen a union rep, let alone a picket line; the number of days lost to strike action in recent years have been, barring a relatively small spike in 2011, at historic lows.
(9) Thom Majka, a sales rep who keeps his Indians cap on through every game for good luck, said: “These fans couldn’t care less about the election.
(10) The law’s sponsor, Republican Rep. Mary Sue McClurkin of Indian Springs, said the measure would make the clinics safer, while clinic operators said it was an attempt to shut them down through a regulation they could not meet.
(11) Reps are asked to sign a contract that includes the clause: “I will not promote the singing of abusive, offensive, crude or intimidating chants and songs.” The contract also asks reps to confirm that they are “the first representative of the University of Nottingham that new students will meet and therefore recognise that [they are] a role model”.
(12) Light responses (ReP) and pre-stimulus membrane potential (PMP) and conductance of photoreceptors of Astacus leptodactylus and Limulus polyphemus (lateral eye) were recorded and changes were observed when the photoreceptor was depolarized by the action of external ouabain of high potassium concentration application.
(13) We propose that REP sequences may be a prokaryotic equivalent of 'selfish DNA' and that gene conversion may play a role in the evolution and maintenance of REP sequences.
(14) Diffraction-limited 1064-nanometer light pulses from a high rep rate Q-switched Nd-YAG laser were coupled through novel means into a probe with index-matched optical contact with the cornea.
(15) And the most jaw-dropping part is that Rep. Sensenbrenner is the same guy who fathered The Patriot Act !
(16) One thing we missed out on was that Justin Bieber wanted to rep BlackBerry .
(17) The crude extract (fraction II) prepared from E. coli could replicate plasmid pKYM, only when the extract contained the rep protein which was produced by the plasmid and essential for its multiplication in vivo.
(18) These results have been used to calculate the geometrical contribution to the error in the measurement of relative effective renal plasma flow (REP) by 131-I-Hippuran renography.
(19) Rep, which makes a sequence-specific single-stranded nick to form a covalent Rep-ori replication intermediate.
(20) Updated at 6.57pm BST 6.49pm BST A congressman, Rep. Dana Rohrabacher (R-CA), once lost an arm-wrestling match against Russian president Vladimir Putin , and now he has told the world about it.