(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Wep
Definition:
() imp. of Weep.
Example Sentences:
(1) The WEP is resolutely neither leftwing nor rightwing but non-partisan.
(2) Two pentosan-rich fractions (water-extractable, WEP, and alkali-extractable, AEP) were isolated from a wheat milling by-product.
(3) To stop strangers hacking into it (and possibly planting malware or changing settings), connect your computer to it via an ethernet cable and enable wireless security, which will either be WEP (Wired Equivalent Privacy) or WPA (Wi-Fi Protected Access).
(4) But a lot of people insist on WEPping us.” It sprung out of a small group that soon became a larger group of like-minded women, gathering in each other’s homes and in bars, and as Mayer, Toksvig and Walker run through the tale of how it came into being, their story skirts many laden tables .
(5) When both WEP and AEP were added to a commercial-type broiler diet the apparent metabolizable energy (AME), nitrogen retention, feed utilization and growth of broilers were significantly (P less than 0.001) depressed.
(6) Net protein utilization (NPU) was examined in pregnant rats fed various levels (1, 3, 6, 10 and 20%) of whole egg protein (WEP), based on their obligatory nitrogen losses.
(7) WEP is now considered weak, but you may find it easier to set up.
(8) The measured penumbra defined by the multileaf collimator is similar to that defined by the same length fixed field-size water extended polyester (WEP) collimator.
(9) Since I left, it has become ground zero of the international aid community and the car park is rammed with 4x4s, the restaurant heaving with people in agency polo shirts – MSF, WEP, UN – and dozens of evacuated climbers and trekkers camping out in orange expedition tents in the gardens.
(10) She asked if anyone fancied joining her in the bar for a chat about starting a new political group and by the time the Women of the World festival had finished on London’s Southbank, Mayer had comedian Sandi Toksvig on board as co-founder of the Women’s Equality Party (WEP).
(11) On Tuesday, the WEP will be exposed to the scrutiny of political pundits with its first policy launch.
(12) I’ve just found out that Sandi Toksvig has been at one time or another a member of the Labour [party], the Conservatives and the Lib Dems, so she is well-placed to have an all-round view!” The WEP see themselves as part of the grassroots movements for change that are swelling across the country, part of a wider phenomenon which has seen Corbyn elected Labour leader, the rise of Ukip and, north of the border, the emergence of groups such as the Women for Independence movement, which has led to hundreds of community-focused groups springing up in Scotland.
(13) The NPUs in pregnant rats fed 1, 3, 6, 10 and 20% WEP diets were 103, 99, 78, 66 and 46, respectively.
(14) The WEP’s first call, for quotas to bring a 50-50 balance to parliament, is a “quick fix measure”, she said.
(15) It might require an administrator password, but that’s okay, the password is ‘admin’.” Bypassing the encrypted WEP wireless system also proved easy.