(1) In contrast to the intact endothelial monolayers, in homogenates additional kininase activity was found which was not affected by either ACE and NEP inhibitors nor by amastatin and MGTA.
(2) These data indicate that mammalian tachykinins induce the release of NCA from BBEC and that NEP modulates these effects.
(3) The nuclear masses are known as (1) the area lateralis hypothalami (ALH), (2) the nucleus entopeduncularis (nEp), (3) the nucleus semilunaris accessorius (nSA), (4) the nucleus ventromedialis hypothalami (nVmH), and (5) the posterolateral portion of the zona incerta (ZI).
(4) The effects of the neutral metalloendopeptidase (NEP) inhibitor, thiorphan, and the angiotensin converting enzyme (ACE) inhibitor, captopril, on airway responses to SP5-11 were examined in order to test the hypothesis that differences in degradation of SP and SP5-11 contribute to the difference in airway responsiveness to the two peptides.
(5) These results suggest that degradation of NKA and NKB by NEP but not by ACE is an important determinant of the bronchoconstriction induced by these peptides.
(6) By cleaving and thus inactivating tachykinins released from sensory nerves, NEP limits the actions of these peptides.
(7) We gave phosphoramidon to inhibit NEP and enalapril maleate or captopril to inhibit ACE.
(8) The effects of neutral endopeptidase inhibition (NEP-I) were studied in 6 conscious sheep with heart failure (HF) induced by rapid ventricular pacing for 7 days.
(9) The present work examined the susceptibility of these novel peptides to hydrolysis by various purified exo- and endo-peptidases including endopeptidases 24.11 (NEP), 24.15, 24.16, angiotensin-converting enzyme, leucine aminopeptidase and carboxypeptidase A. NEP attacked MCH at three sites of the molecule with an apparent affinity of about 12 microM and a kcat.
(10) On the other hand, transient or enhanced expression of NEP is observed during the development of several organs such as the sensory organs, the heart and the major blood vessels, the intestine, the bones and the genital tubercle.
(11) These studies confirm the presence of neutral endopeptidase (NEP) in the nuchal ligament of the fetal calf.
(12) Regional haemodynamic responses to atrial natriuretic peptide (ANP, 0.5 nmol kg-1) or proendothelin-1 [1-38] (1.0 nmol kg-1) were assessed in the same conscious Long Evans rats before and 20 min after administration of the novel neutral endopeptidase (NEP) inhibitor, SQ 28,603 (50 mg kg-1, i.v.).
(13) The activity of NEP, measured with an enzymatic fluorimetric method employing N-dansyl-D-alanyl-glycyl-L-4-nitrophenylalanyl-glycine as a synthetic substrate, was 18 times and eight times higher in the outer stripe of the medulla and inner cortex than in the outer cortex (OC).
(14) There were no significant differences in apparent volume of distribution, elimination half-life, and elimination clearance (CIe) for nEp and rEp in intact dogs.
(15) Also examined were the effects of inhibitors of neutral endopeptidase (NEP) and angiotensin-converting enzyme (ACE).
(16) This binding was displaced in a dose-dependent manner by NEP inhibitors.
(17) Using NEP-expressing MDCK cells and episcopic fluorescence microscopy, a specific labeling was obtained with 100 nM FTI which was completely displaced by 10 microM HACBOGly, a specific and potent inhibitor of NEP.
(18) We concluded that, although covalent bonds appear to be cleaved in NEP by papain, its activity and structure are sustained by S-S bridges.
(19) To determine the distribution of NEP, a possible regulatory enzyme for the neuropeptide-induced leukocyte activation, among human leukocytes, we investigated the enzymatic activity of NEP in each cell type of human peripheral blood leukocytes.
(20) N-ethyl piperidinyl diaminodithiol (NEP-DADT), complexed with 99mTc has been developed as an agent for the measurement of brain blood flow using SPECT.
Yep
Definition:
Example Sentences:
(1) YEp plasmid stability in the presence of either Saccharomyces cerevisiae laboratory strain 2-microns DNA, or lager brewing yeast 2-microns DNA in the same genetic background, was compared under non-selective culture conditions.
(2) Yep, that's right, you could almost set your watch by it.
(3) Apparently there was something in the water as George Hill, immediately fouled by the Wizards with only six seconds left in regulation, went to the line with a two-point Indiana lead and a chance to make it a two-possession game instead, yep, hit only one of his two free throws.
(4) SMR1-410, a dominant resistance marker, was cloned into the FLP gene of 2 microns DNA to produce the chimeric YEp vector pWX823B.
(5) 1.45am BST Tigers 0 - A's 0, bottom of the 2nd Verlander then gets ahead of Brandon Moss, always a strikeout candidate and, yep, he goes swinging for the fourth batter to go the way of the k. 1.43am BST Tigers 0 - A's 0, bottom of the 2nd Seth Smith puts together a great at-bat against Verlander, working a full count, but he takes a strike on the corner to be his third strikeout victim.
(6) Yep, that’s right – Trump may need to defend a law he swore to repeal from an action his own party took.
(7) Lindiwe Mazibuko Photograph: AP 4,667 tweets 432 following 36,612 followers One of the most active tweeters and retweeters in South African politics, with a sprinkling of personal commentary: "Yep.
(8) Furthermore, the high level of intracellular cAMP in ira1 and RAS2Val19 cells was reduced by the MSI1 gene carried on a YEp-based plasmid.
(9) It was also confirmed that increasing cell ploidy enhanced YEp stability under non-selective conditions.
(10) 11.26pm GMT Yep, it seems Liverpool's deal for Konoplyanka is off for sure.
(11) Nadal leads 2-1 in sets Yep, Rafa has held easily throughout this set and does so to love here.
(12) This is how Updated at 1.31am BST 1.22am BST Tigers 0 - A's 0, bottom of the 1st Yep.
(13) Seeing an Asian woman in a white man’s house with kids and telling ourselves: ‘Yep, that’s the nanny.
(14) The KHR gene cloned from a genomic library was on 4.7-kbp DNA fragment and was inserted into YCpG11 vector (KHR-YCp) and YEp vector (KHP-YEp).
(15) The Nd-Fe-B magnet as rare earth magnet, and SUSXM 27, YEP-3, SUS 416 as ferromagnetic stainless steel were used in this experiment.
(16) VAL2C(YEp CHO1) is a plasmid-bearing strain that over produces phosphatidylserine synthase activity, and the opi1 mutant is an inositol biosynthesis regulatory mutant.
(17) The generation time of the selected mutants on YEP glucose was 6-8 h. No ethanol was formed from glucose and the levels of respiration were very high.
(18) Such fragments were placed 5' to 3' and 3' to 5' under control of the GAL10 promoter and CYC1 terminator in a high copy YEp plasmid.
(19) You see a kid who lifts his head up, who plays the pass first time, pum, and you think, 'Yep, he'll do.'
(20) During non-selective yeast growth, pRS420 plasmids are lost through mitotic segregation at rates similar to other YEp vectors and yeast centromeric plasmid (YCp) vectors, in the range of 1.5-5% of progeny per doubling.