What's the difference between nitro and nitroform?

Nitro


Definition:

Example Sentences:

  • (1) A new type of Escherichia coli mutant which shows increased sensitivity to methyl methane sulfonate but not to UV light or to gamma rays was isolated after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine.
  • (2) Sec-alpha-halo-nitro compounds are active antibacterial and antifungal agents, and the sec-bromo derivatives are the most active and stable.
  • (3) A series of 2-styryl-5-nitro-1-vinylimidazoles carrying alkylaminomethyl or amidino functions in the 4 position of the styryl ring was prepared and evaluated for antitrypanosomal activity in mice infected with Trypanosoma rhodesiense.
  • (4) The effects of Ng-nitro-L-arginine were reversed by L-arginine.
  • (5) The best compound was trans-alpha-[[(4-bromotetrahydro-2H-pyran-3-yl) amino]methyl]-2-nitro-1H-imidazole-1-ethanol (18), which, due to its activity and log P value, is a candidate for additional in vivo studies.
  • (6) In addition, cell lines exhibiting increased resistance to N-methyl-N'-nitro-N-nitrosoguanidine have been derived from a cell line expressing the Ada protein methylphosphotriester repair function.
  • (7) It is likely that nitro substitution at the 6-position of 5-MeC interferes with the structural requirements of the 1,2-diol-3,4-epoxide which are necessary for specific DNA interactions.
  • (8) After mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine and penicillin selection, two kinds of B(12) transport mutant were isolated from this strain.
  • (9) AOAA-induced (0.25 mumol-1 mumol) striatal lesions in adult rats displayed excitotoxic characteristics and could be prevented by the N-methyl-D-aspartate (NMDA) receptor antagonists (-)-2-amino-7-phosphono-heptanoate (AP7; 0.25 mumol) or kynurenate (KYNA; 0.5 mumol), but not by the non-NMDA antagonist 2,3-dihydroxy-6-nitro-7-sulphamoyl-benzo(F)quinoxaline (NBQX; 0.25 mumol).
  • (10) The oxidation of the anion radical intermediate by O2 to the parent nitro compound is proposed to account for the well-known O2 inhibition of microsomal nitroreductase.
  • (11) The complexes are produced by attachment of a carbon of the butenolide ring to an aromatic carbon of the nitro compound with formation of a charge-delocalized cyclohexadienate anion.
  • (12) With these compounds, the spin density at the nitro group was greater than with nifurtimox, nitrofurazone and nitrofurantoin.
  • (13) Amino and nitro groups, introduced at position-4 of estrone 3-methyl ether were particularly carcinostatic, a property not shared by 4-bromoestrone 3-methyl ether.
  • (14) The labeled egg albumin was hydrolyzed in 6N HCl at 110 degrees C for 24 h. The hydrolysate was lyophilized, derivatized with 4-fluoro-7-nitro-2,1,3-benzoxadiazole, a fluorogenic reagent for amines, and subjected to HPLC.
  • (15) Nitroreductases must therefore be able to compete successfully with molecular oxygen for the MISO nitro radical-anion in such tissues.
  • (16) It has been suggested that under aerobic conditions the aziridine ring is primarily responsible for aerobic toxicity, whereas under hypoxic conditions, the aziridine moiety combined with a reduced 2-nitro moiety produces a bifunctional agent (I. J. Stratford et al., Br.
  • (17) N omega-Nitro-L-arginine methyl ester (NAME) (10(-5) to 5 x 10(-4) M) abolished ijps in both tissues, an effect overcome by 10(-3) M L-arginine but not D-arginine.
  • (18) The incidence, number, and histological types of gastric cancers induced by N-methyl-N'-nitro-N-nitrosoguanidine and the tissue norepinephrine concentration of the gastric wall were investigated in spontaneously hypertensive rats and in control Wistar Kyoto rats and Wistar rats.
  • (19) A nitroreductase enzyme has been isolated from Walker 256 rat carcinoma cells which can convert 5-(aziridin-1-yl)-2,4-dinitrobenzamide (CB 1954) to a cytotoxic DNA interstrand crosslinking agent by reduction of its 4-nitro group to the corresponding hydroxylamino species (Roberts JJ et al., Biochem Biophys Res Commun 140: 1073-1078, 1986; Knox RJ et al., Biochem Pharmacol 37: 4661-4669, 1988).
  • (20) In contrast, nordihydroguaiaretic acid, metyrapone, NG-monomethyl-L-arginine, and nitro-L-arginine all attenuated the relaxation to acetylcholine; however, indomethacin had no effect on acetylcholine-induced relaxations.

Nitroform


Definition:

  • (n.) A nitro derivative of methane, analogous to chloroform, obtained as a colorless oily or crystalline substance, CH.(NO2)3, quite explosive, and having well-defined acid properties.

Example Sentences:

  • (1) The initial rate of substrate- and enzyme-dependent nitroform production was linearly related to functional active site content.
  • (2) The addition of n-butylamine to assay mixtures containing lysyl oxidase and TNM markedly increased the background rate of nitroform release.
  • (3) Isocitrate lyase of germinating castor seed endosperm catalyzes the reactions of succinate and of isocitrate (but not of glyoxylate) with tetranitromethane (TNM), giving rise to the nitroform anion (C-(NO2)3), analogous to the reaction of TNM with carbanions (O.P.
  • (4) The Km for n-butylamine was essentially the same whether determined from the rate of lysyl oxidase-catalyzed nitroform release or from the rate of n-butyraldehyde production in the absence of TNM, the latter assessed by measurements of the rate of H2O2 formation.

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