(n.) A rounded mass or irregular shape; a little knot or lump.
Example Sentences:
(1) This particular variant of rheumatoid arthritis (RA) is characterized by the presence of subcutaneous rheumatoid nodules, scanty or absent systemic manifestations and a clinically benign course.
(2) We identified four distinct clinical patterns in the 244 patients with true positive MAI infections: (a) pulmonary nodules ("tuberculomas") indistinguishable from pulmonary neoplasms (78 patients); (b) chronic bronchitis or bronchiectasis with sputum repeatedly positive for MAI or granulomas on biopsy (58 patients, virtually all older white women); (c) cavitary lung disease and scattered pulmonary nodules mimicking M. tuberculosis infection (12 patients); (d) diffuse pulmonary infiltrations in immunocompromised hosts, primarily patients with AIDS (96 patients).
(3) An umbilical nodule may be an early or late sign of metastasis from an internal location.
(4) Thus, multiparae had very thick border zones composed predominantly of large nodules and, additionally, of vacuolated cells and fibrous tissue.
(5) In two cases that showed punctate or linear low density structures adjacent to the distal side of the tumor nodules to the porta hepatis, a daughter nodule was detected by CT at 6.5 and 9.2 months, respectively, after the appearance of the low density structures.
(6) Based on their localisation and histology these are classified into three types (Epstein's pearls, Bohn's nodules, Dental lamina cysts).
(7) No infection threads were found to penetrate either root hairs or the nodule cells.
(8) Two-thirds of the respiratory infections occurred in the first 3 postoperative months and were generally localized processes (focal pneumonitis, nodule(s), abscess, or empyema).
(9) Differential degeneration of the lateral microvessels may account for increases in collagen nodule growth and ultimate size.
(10) In this study, six patients, the proband, his four siblings and a niece, representing a kindred of fifty-two subjects, were examined for aymptomatic cutaneous nodules mainly on the back and chest.
(11) Significantly higher levels of c-myc gene expression were observed in tissues of HCC of the DEN group and in neoplastic nodules of the DEN-DES groups than in the DES and DEN-C group.
(12) On siratro, CIAT899 induced nodules that were ineffective in acetylene reduction, whereas the EPS-deficient mutants induced effective nodules.
(13) Yellow lupin nodule specific sequences were selected by screening of cDNA library prepared from lupin nodule poly(A)+RNA.
(14) These were not seen after the 35th day, however an occasional lymph nodule persisted in the intersitium.
(15) However, there is no reported study which compares the long-term outcome of patients with vocal cord nodules treated surgically with those treated with a combination of surgery and speech therapy, and those treated only with speech therapy.
(16) Fine needle aspiration of the thyroid is suggested as an initial diagnostic procedure in the evaluation of thyroid nodules.
(17) Here a diaphragm support breath pattern was used in voice therapy for patients with vocal nodules, recurrent laryngeal nerve paralysis, and incomplete glottal closure.
(18) The development of the nodules did not seem to affect the hosts.
(19) Neoplastic nodules showed a variable pattern of enzyme activities.
(20) Negative slit smears for AFB from the nodules repeatedly and the histology of one on the skin nodules clinched the diagnosis of multicentric reticulohistiocytosis.
Xanthoma
Definition:
(n.) A skin disease marked by the development or irregular yellowish patches upon the skin, especially upon the eyelids; -- called also xanthelasma.
Example Sentences:
(1) The reason(s) for the xanthoma formation and premature atherosclerosis are not clearly understood.
(2) The three xanthomas from two FH homozygotes exhibited marked lipid accumulation in histiocytic foam cells but no lipid deposits in the endothelium of blood vessels in the lesions.
(3) This rare lesion, previously reported to occur only in the oral cavity, is characterized by a verrucous epithelial proliferation accompanied by xanthoma cells distributed exclusively in the papillary dermis.
(4) A skin biopsy demonstrated infiltration of xanthoma cells and foamy cells in the dermis.
(5) The clinical consequences of familial hypercholesterolemia (FH) result from its metabolic peculiarities that persist from very early childhood, leading to the accumulation of cholesterol in the form of xanthomas in skin and tendons and atheromatous lesions in the arterial wall, in particular, in the aorta and the stem of coronary arteries.
(6) Perhaps in some way plant sterols initiated the development of xanthomas with otherwise normal plasma cholesterol levels.
(7) In the remaining family, the proband and his sibling, both having relatively severe hypercholesterolemia and Achilles tendon xanthomas, shared an RFLP haplotype, although the proband's other sibling with moderate hypercholesterolemia but without Achilles tendon xanthomas did not.
(8) Xanthelasma palpebrarum is the most common xanthoma and is associated with other xanthomas or hyperlipemia syndromes in only 5 percent of the patients--even though one third of the affected patients have an elevated serum cholesterol level.
(9) A 47-year-old male patient with tuberous xanthomas, xanthochromia striata palmaris, hypercholesterolemia, hypertriglyceridemia, chylomicronemia and a "broad-beta" band on agarose gel electrophoresis is the subject of this report.
(10) To explore whether the reported xanthoma-reducing effects of probucol are related to tissue-specific mechanisms of the drug, the influence of probucol on cholesterol efflux from cultured human skin fibroblasts was investigated.
(11) Survivors at ages of 19 months to 16.5 years had considerable morbidity with pruritus occurring in 70%, jaundice in 48%, xanthomas in 30%, 74% having hepatomegaly and 63% splenomegaly.
(12) The histologic diagnosis was sclerosing (ossifying) xanthoma.
(13) Intracranial fibrous xanthoma is extremely rare; only 11 cases have been reported so far.
(14) On the other hand, severe talagia was rarely found in rheumatoid arthritis, and no case was related to the presence of tophi or xanthomas of the Achilles tendon.
(15) Large Achilles tendon xanthomas of the type found in severe familial hypercholesterolemia were the first manifestation of cholestanolosis (cerebrotendinous xanthomatosis) in our patient, an otherwise asymptomatic normolipidemic 21-year-old woman.
(16) They differed, however, from the typical presentation in lacking the Achilles tendon xanthomas characteristic of this condition.
(17) Cerebrotendinous xanthomatosis is a rare hereditary disease, which manifests with tendinous xanthomas, cataracts, dementia and nervous system involvement.
(18) Xanthoma was produced in diet-induced hypercholesterolemic rabbits by intradermal dextran sulfate injections.
(19) These findings support previous biopsy data indicating active uptake of LDL by macrophages within xanthoma and suggest that 99mTc-LDL imaging of xanthomas may be useful in studies of the effects of diet and drugs on the accumulation of lipoproteins by atherosclerotic plaques.
(20) And there was a collection of xanthoma-like foamy cells and invasive inflammatory cells.