(1) GH8----GH1' NOEs demonstrate the presence of both A- and Z-form GH8 resonances in slow exchange on the NMR time scale.
(2) Examination of the NOESY data at 50- and 100-ms mixing times indicated that the kinds of observed NOEs can originate if each of the ten nucleotidyl residues belongs to the B-DNA family, i.e., C2'-endo,anti.
(3) The backbone dynamics of Ca(2+)-saturated recombinant Drosophila calmodulin has been studied by 15N longitudinal and transverse relaxation experiments, combined with 15N(1H) NOE measurements.
(4) The local secondary structure was calculated from sequential and medium-range backbone NOEs with the double-iterated Kalman filter method [Altman, R. B., & Jardetzky, O.
(5) The integration of these facilities with simple molecular graphics display routines allows modifications to the molecular conformation (such as bond rotations) to be performed, and the effect of these modifications on the NOE effects can then be rapidly calculated and easily visualized.
(6) The other two hyperfine-shifted signals produced no detectable NOEs to other resonances in the spectrum and were tentatively assigned to the remaining cysteinyl ligand (Cys-63).
(7) Amide solvent accessibility, NOE spectroscopy (NOESY) and rotating-frame NOE spectroscopy (ROESY) data strongly support the conclusion that the 12-26 and 15-23 peptides adopt in aqueous solution, a set of turn-like structures located around the central region of their corresponding polypeptidic chains, the same region where a beta turn exists in the native protein.
(8) Initial conformations for energy minimization were selected with the aid of the measured intensities of local nuclear Overhauser effects (NOEs) and other 1H-NMR data.
(9) Changes in chemical shifts and NOEs for wild type with bound phosphate compared with free wild type indicate that phosphate binds in the active site and that only small conformational changes occur on binding.
(10) The conformations of the cyclic hexapeptides in DMSO-d6 solution were determined by a number of homo- and heteronuclear two-dimensional n.m.r.-techniques including 2D rotating frame NOE-spectroscopy.
(11) Complete assignments were obtained for the backbone 1H, 15N and 13C resonances, using three-dimensional heteronuclear 1H NOE 1H-15N multiple-quantum coherence spectroscopy (3D-NOESY-HMQC) and three-dimensional heteronuclear total correlation 1H-15N multiple-quantum coherence spectroscopy (3D-TOCSY-HMQC) experiments on 15N-enriched HPr and an additional three-dimensional triple-resonance 1HN-15N-13C alpha correlation spectroscopy (HNCA) experiment on 13C, 15N-enriched HPr.
(12) Although the assignment of this dodecadeoxynucleotide may be completed without deuteriation, several NOEs must be assigned indirectly because of degeneracies in the chemical shift of the purine H8 protons.
(13) The complexation-induced chemical shifts and NOE cross peaks in the NOESY map of the 1:1 complex of lexitropsin (1) and d-[CGCAATTGCG]2 reveal that the thiazole ring of the lexitropsin (1) intercalates between dA4.A5 bases and the rest of the ligand resides in the minor groove of the AT rich core of decamer, thus occupying the 5'-AATT sequence on the DNA.
(14) An approximate analysis of the NOE data assuming a single correlation time for the entire molecule and ignoring cross-relaxation effects was used to evaluate various models that have been proposed for the conformation of valinomycin.
(15) In addition, a number of tertiary NOEs have been identified which indicate that the global fold of the apoprotein at least partially resembles the four-helix bundle of the holoprotein.
(16) The resulting pattern of NOE cross-relaxation peaks when combined with previous 1D NOE results [Dugad, L. B., La Mar, G. N., Banci, L., & Bertini, I.
(17) The pyridazine acetylmethyl groups give NOEs to the C(alpha)H groups of the beta-hydroxy-N-methylvaline residues, showing that the acetyl groups, for at least some of the time, stretch over the depsipeptide ring, occluding one face of the molecule.
(18) Nuclear runoff analysis of the late region has demonstrated that up to 95% of transcripts which are initiated in the early region in nonpermissive cells terminate within the late region upstream of the late polyadenylation site (C. C. Baker and J. Noe, J. Virol.
(19) Its structure was elucidated by IR, UV, FAB-MS, and various NMR spectra (including NOE, BBD, INEPT, SR, COSY, NOESY etc.
(20) Three methods of obtaining distance constraints from 2D NOE peak intensities are examined: one entails a conservative use of ISPA, one assumes the ISPA to be fairly accurate, and one utilizes an iterative relaxation matrix method called MARDIGRAS (matrix analysis of relaxation for discerning the geometry of an aqueous structure), developed in this laboratory.
Nous
Definition:
(n.) Intellect; understanding; talent; -- used humorously.
Example Sentences:
(1) He offered up a further example of his lack of economic nous: his failure to notice that the Sun had not paid him for his column for 18 months.
(2) Up the hill, the prince was trying out his schoolboy French – " C'est un honneur pour nous d'être parmi vous … merci votre patience avec mon accent " – and was cheered for doing so.
(3) Steven Gerrard has neither the discipline or the tactical nous to play as a defensive midfielder, they said; and yet here he is having one of the best seasons of his career, inspiring all around him.
(4) They were able to present him with a thriving youth system, a new state-of-the-art training ground, boardroom nous, a strong recruitment team and the basis of a good squad.
(5) Nous sommes tous Français (We are all French).” By contrast, Hollande said that Trump’s excesses “make you want to retch” .
(6) Housing associations’ commercial nous and social entrepreneurship has delivered billions of pounds worth of housing.
(7) The favoured chant of the day is " On est chez nous! "
(8) We’ve got to look to kick on next season.” One definite arrival is the Belgian forward Divock Origi but, aged 20 and having competed in only two full seasons for Lille, he is another who cannot be asked to add nous immediately.
(9) It seemed only a matter of time before the close control and deft passing of the Spain forward set up a colleague with a scoring opportunity, yet in the absence of Agüero and Edin Dzeko City seemed to lack anyone with the nous to find the space Silva was looking to exploit.
(10) She revels in her naivete, as though by admitting her lack of City nous she is proving she is on the side of the people in the great battle between the pinstripes and the proles.
(11) By contrast, Rosneft is seen as bureaucratic, inefficient and lacking commercial nous.
(12) Growing up in Pretoria, the son of a Canadian mother and South African father, he taught himself coding and software, mixing geek talent with business nous: he designed and sold a video game, Blastar, by the age of 12.
(13) He was widely regarded as having the right experience, deft touch and nous to navigate the shoals and shifting currents of continental politics that would buffet the British ship of state as it left its European berth.
(14) The film kind of dupes us into finding Elle every bit as silly and superficial as her peers do, before revealing her whip-smart legal nous and steely sense of integrity (feminist).
(15) The Villa manager, who admitted Liverpool had "too much nous and experience for us", felt his side were "sloppy" in the second half, when Guzan made flying saves to repel efforts from Glen Johnson and Jonjo Shelvey and Suárez hit the woodwork twice.
(16) She has smart commercial nous but has also overseen Sky improve its public service credentials.
(17) Mr Allardyce reportedly impressed the FA with his sophisticated take on sport psychology and has a tactical nous sure to surprise, especially following Roy Hodgson.
(18) Zuma has regained it but now he will need the tactical nous to deal with the fallout," he said.
(19) Sayida Ounissi (@SaidaOunissi) Nous n'avons pas peur.
(20) Jenna Lyon at the J.Crew headquarters in New York Photograph: Danielle Levitt J Crew's USP is fashion nous mixed with accessibility – a relatively basic flowered T-shirt with high-waisted denim shorts, or a single-breasted navy blue blazer worn cape-style.