(1) The CD4+ T cell clones and IL-2 stimulated surface IgM-IgG+ and IgM-IgA+, but not IgM+IgG- or IgM+IgA- B cells to secrete IgG and IgA, respectively, indicating that they induced a selective expansion of IgG- and IgA-committed B cells rather than isotype switching in Ig noncommitted B cells.
(2) The role of the "immunologically noncommitted" cells in graft rejection is unknown.
(3) A noncommitted VSD was an incremental risk factor, two (50%) of four dying after repair.
(4) The effects of lipid A, outer membrane lipoprotein, and murein were evaluated at several distinct stages: induction of colony-stimulating activity (CSA) in the serum, increase in the number of committed splenic precursor cells (CFU-C) forming granulocyte-macrophage colonies in vitro, and triggering into the cell cycle of noncommitted hemopoietic stem cells (CFU-S) from bone marrow.
(5) They also suggest that a second dose of PHA may stimulate some of the original noncommitted lymphocytes to undergo mitosis thus attempting to maintain the in vitro lymphocyte population.
(6) Until the cytogenesis of PTC is clarified we propose the noncommitted term "plasmacytoid T-zone cells" for this elusive cell type.
(7) We investigated the roles of second messengers in K-562 cell differentiation induced by either commitment-inducing agents (Ara-C, thymidine), or a noncommitment-inducing agent (hemin).
(8) The late results were good in the remainder and in the two surviving patients with noncommitted VSD.
(9) From these, 18 hearts with potentially noncommitted defects were identified and studied in detail.
(10) A case is described which exhibited Double Outlet Right Ventricle (DORV) with l-malposition of the aorta in association with a ventricular septal defect of the noncommitted, atrioventricular canal variety.
(11) Individuals who were in committed relationships were better able to cope with the stressors of medical school than their noncommitted colleagues, as evidenced by their reporting fewer depressive episodes and lower use of alcohol and drugs.
(12) In cells committed to differentiate, JS-8 caused an arrest at the erythroblast or early reticulocyte stage, followed by premature cell death, whereas proliferation of noncommitted erythroid cells or other hematopoietic cells remained unaffected.
(13) A 3-year-old boy underwent successful surgical correction of double-outlet right ventricle (S, D, D), noncommitted ventricular septal defect (VSD) of the endocardial cushion type, and pulmonary stenosis.
(14) We report data which demonstrates B-FGF can influence noncommited and specific lineage-derived hematopoietic progenitors when incubated in vitro.
(15) Results in patients with noncommitted ventricular septal defect have remained poor.
(16) Alternatively, the observed class pattern may be induced by an isotype noncommited helper clone which triggers selected population of B lymphocytes of defined differentiation status toward secretion of a restricted array of isotypes.
(17) Conditioned medium derived from peripheral mononuclear low-density cells stimulated with phytohemagglutinin (PHA) supports the growth of noncommitted hematopoietic progenitors from marrow and peripheral blood cells.
(18) On the other hand, in the case of heme, a noncommitting inducer of hemoglobin synthesis, induction of hemoglobin synthesis and increase in heme degradation activity may be independent.
(19) This discrepancy in the alteration of specific clones of lymphocytes compared to all noncommitted lymphocytes may account for varying reports of the immune status of the pregnant woman.
(20) The cell of origin of this tumor appears to be a noncommitted mesenchymal cell present in the areolar tissue subjacent to the mesothelial lining.
Umbrage
Definition:
(n.) Shade; shadow; obscurity; hence, that which affords a shade, as a screen of trees or foliage.
(n.) Shadowy resemblance; shadow.
(n.) The feeling of being overshadowed; jealousy of another, as standing in one's light or way; hence, suspicion of injury or wrong; offense; resentment.
Example Sentences:
(1) On Thursday he also took umbrage at Vladimir Putin's New York Times op-ed criticising US militarism.
(2) The Tory minister took umbrage and in an open letter published on the PoliticsHome website , accused her of "backing the destruction of one of the most effective schemes we have for helping young people get into work".
(3) The senior Democrat on the intelligence committee, Adam Schiff of California, took umbrage at Trump’s implication that “the intelligence community is lying” and said Trump was not acting presidentially.
(4) Indeed, the outrage and umbrage – most of all, it seems, about Obama "cadence" – deflates as it is uttered.
(5) It is not clear if Morsi himself took umbrage or whether his entourage has given instructions to silence the satirist – or at least remind him of the line not to cross.
(6) WPP has also taken umbrage at the methodology which ISS has used, which benchmarks the company against FTSE 100 companies in the UK.
(7) Chris Evans does not take umbrage when I tell him he has movie-star anonymity.
(8) MSNBC's resident ranter and news commentator Keith Olbermann – who once described a Republican senator as "an irresponsible, homophobic, racist, reactionary, ex-nude model" – tweeted his umbrage at Stewart's intimation that he is unhelpfully hyperbolic, possibly before smashing his Blackberry underfoot.
(9) He takes umbrage, at this more than anything else I’ve asked.
(10) Well, celebrity is a word I take great umbrage with.
(11) On the basis of the present study and related previous ones, tumor inhibition appears to be due not to an umbrageous effect but rather to the induction of systemic physiological responses.
(12) Although the Obama administration defiantly vowed to continue its own bombing operations in Syria - and took umbrage at Russia’s insistence on Wednesday that the US ground its aircraft – the US military revealed on Thursday that it launched only a single airstrike in the wake of the Russian campaign.
(13) 12.44pm BST An email, from Claire McConnell: "I know you didn’t write that phrase, and that the MLS is no example of quality football, but as a resident of Toronto, a great city, I have to take umbrage at the “boondocks” word."
(14) Intelligence professionals take great pride in their work … But when there is baseless criticism and impugning the integrity and the mission of intelligence officers, yeah – they take umbrage at that and will continue to do so and I will certainly do,” Brennan said.
(15) But after 40 years, staff and freelance, memories crowd in and old umbrages flower lie mutant cacti.
(16) Wawrinka took umbrage with Lopez's chuntering during the third set and asked the umpire to tell him to stop, which led to much finger-pointing at the net after the match.
(17) It tweeted a picture of one effigy rolling past its offices: “A sneak preview of Alex Salmond and Nessie ahead of tonight’s bonfire in Lewes – it just rolled up at County Hall.” As Scottish independence campaigners took mild umbrage on Twitter, the council quickly deleted the tweet and denied responsibility .
(18) One strain of reaction to Feinstein’s sudden umbrage at what she characterized as the invasiveness and unruliness of CIA practices is, Why is it OK when it’s done to the public, but not OK when it’s done to Senate staffers?
(19) The leader of the Green party, Cem Özdemir, who took part in the counter-protest, told the Guardian: “Being in a party whose members took part in the 1989 Monday demos, I take great umbrage at the abuse of the slogan used back then, ‘Wir sind das Volk’.
(20) The UK’s largest mobile phone company has taken umbrage at 3’s latest adverts, in particular one strapline where it claims it is the “undisputed” leader.