(a.) Of recent origin or introduction; not ancient; new; hence, out of the ordinary course; unusual; strange; surprising.
(a.) That which is new or unusual; a novelty.
(a.) News; fresh tidings.
(a.) A fictitious tale or narrative, professing to be conformed to real life; esp., one intended to exhibit the operation of the passions, and particularly of love.
(a.) A new or supplemental constitution. See the Note under Novel, a.
Example Sentences:
(1) Moreover in MIT-1, the size of the novel polypeptide was not that predicted of the precursor (44.9 kDa) but was about 39 kDa, the same size as the authentic GS gamma polypeptide in CYT-4.
(2) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(3) A novel prostaglandin E2 analogue, CL 115347, can be administered transdermally on a long-term basis.
(4) The lipid A moiety was shown to be responsible for this novel biological activity of the LPS molecule.
(5) Experiment 3 showed that the color-induced increase in odor intensity is not due to subjects' preexperimental experience with particular color-odor combinations, because the increase occurred with novel ones.
(6) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(7) But what they take for a witticism might very well be true; most of Ellis's novels tell more or less the same story, about the same alienated ennui, and maybe they really are nothing more than the fictionalised diaries of an unremarkably unhappy man.
(8) Cyclosporine is a fungal endecapeptide of novel chemical structure that causes preferential inhibition of T helper cells.
(9) As novel antibody therapeutics are developed for different malignancies and require evaluation with cells previously uncharacterized as antibody-dependent cell-mediated cytotoxicity (ADCC) targets, efficient description of key parameters of the assay system expedites the preclinical assessment.
(10) Her novels have an enduring and universal appeal and she is recognised as one of the greatest writers in English literature.
(11) The complex problems have been successfully managed with novel guiding catheter shapes and ultralow profile balloons.
(12) Moreover, the most recent combined application of the rat interstitial cell testosterone (RICT) bioassay and a novel multiple-parameter deonvolution model has allowed investigators to dissect plasma concentration profiles of bioactive LH into defined secretory bursts, which have numerically explicit amplitudes, locations in time, and durations, and are acted upon by determinable subject- and study-specific endogenous metabolic clearance rates.
(13) The extensive conversion of anti-BPDE to B[a]PT-10-sulfonate under conditions where sulfite enhances diolepoxide mutagenicity, when coupled with this enhancement of diolepoxide mutagenicity by B[a]PT-10-sulfonate in the reverse mutation assay, supports this novel B[a]P derivative as a mediator of the sulfite-dependent enhancement of B[a]P genotoxicity.
(14) This novel coumarin derivative significantly inhibited skin tumor initiation by DMBA in SENCAR mice when given at a dose of 200 nmol, 5 min (69% inhibition) or 24 h (76% inhibition) prior to initiation.
(15) Using a novel method for joining DNA sequences, we have exploited this difference between the two enzymes to identify the regions of the RT that contribute to the compounds' inhibitory activities.
(16) It may thus represent an artifact of the labeling procedure rather than a novel basophil-derived prostaglandin.
(17) Endothelin-1 (ET-1) is a novel vasoconstricting and cardiotonic peptide that is synthesized by the vascular endothelium.
(18) These observations indicated a novel mechanism that in the absence of light-dark schedule, mothers taught the circadian rhythm to the pups as they raised them.
(19) Pretreatment with a novel CRF antagonist, alpha-helical CRF9-41 (130.9 nmol i.t.v.
(20) Prions are novel, transmissible pathogens causing degenerative diseases of the central nervous system both in humans and in animals.
Nowel
Definition:
(n.) Christmas; also, a shout of joy at Christmas for the birth of the Savior.
(n.) A kind of hymn, or canticle, of mediaeval origin, sung in honor of the Nativity of our Lord; a Christmas carol.
(n.) The core, or the inner part, of a mold for casting a large hollow object.
(n.) The bottom part of a mold or of a flask, in distinction from the cope; the drag.
Example Sentences:
(1) The BCR gene (Groffen et al., 1984) plays a critical role in the pathogenesis of human leukemias that involve the Philadelphia chromosome (Ph1) (Rowley, 1973; Nowell & Hungerford, 1960).
(2) David Nowell Fellow of the Geological Society • Zoe Williams’ excellent piece deserves a medal for telling us, in a world of distortions, the truth about migration and also reminding us that welcoming the stranger is essential for our growth as human beings.
(3) In contrast, previous in vitro studies of bcl-2 mRNAs showed that expression of this gene is very low in unstimulated PBLs but can be markedly induced when lymphocytes are stimulated to proliferate in culture (Reed JC, Tsujimoto Y, Alpers JD, Croce CM, Nowell PC.
(4) The first consistent karyotypic abnormality found to be associated with neoplastic disease was the Philadelphia (Ph) chromosome (Nowell & Hungerford, 1960).
(5) As Stanbridge and Nowell stated at the conclusion of a recent Cold Spring Harbor meeting on the Origins of Human Cancer, "We have come a long way.
(6) Doing so by a big score is huge, but we came within a collapsed maul on the line of doing so.” Paul O’Connell’s cool head leads Ireland through Six Nations furnace | Andy Bull Read more The wing Jack Nowell scored two of England’s seven tries, including the final one that set up the frantic finish.
(7) People caught fiddling more than the living wage should have their tax returns published David Nowell Our country is fit to live in because of its essential infrastructure of transport, fire services, the police, education, the health service, the military and so on, all paid for with our taxes.
(8) David Nowell New Barnet, Hertfordshire • Within days of his election, Jeremy Corbyn is in danger of falling into a classic Cameron trap.
(9) In 1960, Nowell and Hungerford found, for the first time, a minute chromosome at the metaphase in chronic myelocytic leukemia (CML) cells, which was called Philadelphia chromosome (9; 22 translocation) later.
(10) David Nowell New Barnet, Hertfordshire • Your front-page article ( HMRC knew of wrongdoing, but did not prosecute bank , 10 February) highlights the most shocking aspect of this whole sorry affair.
(11) Henry Slade, Jack Nowell, Danny Care and Alex Goode will be itching to impress having waited all tournament for a start but the absence of a midfield presence to run some hard, sharp lines may not help.
(13) Ben Youngs spotted a prop guarding a ruck and jogged past him to send in Ford; Rory Kockott kicked a penalty after Billy Vunipola failed to roll away; Nowell stepped out of trouble for his first try: Mermoz’s delayed pass to Nakaitaci set up a try for Vincent Debaty; Billy Vunipola forced his way over; then Benjamin Kayser did the same.
(14) In 1960, Nowell and Hungerford found, for the first time, a minute chromosome at the metaphase in chronic myelocytic leukemia (CML) cells, which was called Philadelphia chromosome (Ph1 chromosome) later.
(15) The hypothesis of tumor progression proposed by Nowell [P. C. Nowell, Science (Wash. DC), 194: 23-28, 1976] states that one mechanism for the development of the metastatic phenotype could be the induction of chromosomal instability.
(16) These findings support Nowell's hypothesis that the stem line is different for each solid tumor, which makes it difficult to relate chromosomal changes to the initiation of the neoplastic state.
(17) Genetic instability has been hypothesized by P. C. Nowell and other investigators to be an important aspect of tumor progression that leads to the generation of metastatic variants.
(18) Nowell’s second try seemed to tilt the match towards England, as if they were touched by destiny.
(19) These experimental observations strongly support Nowell's clonal evolution model of tumour progression.
(20) In addition, we will attempt to integrate the concept of the unicellular behavior of tumor cells with Foulds' and subsequently Nowell's insightful hypothesis concerning tumor progression.