(a.) Of recent origin or introduction; not ancient; new; hence, out of the ordinary course; unusual; strange; surprising.
(a.) That which is new or unusual; a novelty.
(a.) News; fresh tidings.
(a.) A fictitious tale or narrative, professing to be conformed to real life; esp., one intended to exhibit the operation of the passions, and particularly of love.
(a.) A new or supplemental constitution. See the Note under Novel, a.
Example Sentences:
(1) Moreover in MIT-1, the size of the novel polypeptide was not that predicted of the precursor (44.9 kDa) but was about 39 kDa, the same size as the authentic GS gamma polypeptide in CYT-4.
(2) A novel bicyclic prostaglandin analogue, (1S)-[1 alpha,2 alpha(Z),3 alpha,4 alpha]-7-[3-[(hexylthio)methyl]-7- oxabicyclo [2.2.1]hept-2-yl]-5-heptenoic acid ((-)-10), and its cogeners were found to be potent antagonists at the TxA2 receptor.
(3) A novel prostaglandin E2 analogue, CL 115347, can be administered transdermally on a long-term basis.
(4) The lipid A moiety was shown to be responsible for this novel biological activity of the LPS molecule.
(5) Experiment 3 showed that the color-induced increase in odor intensity is not due to subjects' preexperimental experience with particular color-odor combinations, because the increase occurred with novel ones.
(6) This novel mechanism of receptor regulation, named transmodulation, should be distinguished from the reduction in total receptor number caused by the homologous ligand (downregulation) and from the change in affinity produced by the binding of agonists or antagonists to the same receptor site.
(7) But what they take for a witticism might very well be true; most of Ellis's novels tell more or less the same story, about the same alienated ennui, and maybe they really are nothing more than the fictionalised diaries of an unremarkably unhappy man.
(8) Cyclosporine is a fungal endecapeptide of novel chemical structure that causes preferential inhibition of T helper cells.
(9) As novel antibody therapeutics are developed for different malignancies and require evaluation with cells previously uncharacterized as antibody-dependent cell-mediated cytotoxicity (ADCC) targets, efficient description of key parameters of the assay system expedites the preclinical assessment.
(10) Her novels have an enduring and universal appeal and she is recognised as one of the greatest writers in English literature.
(11) The complex problems have been successfully managed with novel guiding catheter shapes and ultralow profile balloons.
(12) Moreover, the most recent combined application of the rat interstitial cell testosterone (RICT) bioassay and a novel multiple-parameter deonvolution model has allowed investigators to dissect plasma concentration profiles of bioactive LH into defined secretory bursts, which have numerically explicit amplitudes, locations in time, and durations, and are acted upon by determinable subject- and study-specific endogenous metabolic clearance rates.
(13) The extensive conversion of anti-BPDE to B[a]PT-10-sulfonate under conditions where sulfite enhances diolepoxide mutagenicity, when coupled with this enhancement of diolepoxide mutagenicity by B[a]PT-10-sulfonate in the reverse mutation assay, supports this novel B[a]P derivative as a mediator of the sulfite-dependent enhancement of B[a]P genotoxicity.
(14) This novel coumarin derivative significantly inhibited skin tumor initiation by DMBA in SENCAR mice when given at a dose of 200 nmol, 5 min (69% inhibition) or 24 h (76% inhibition) prior to initiation.
(15) Using a novel method for joining DNA sequences, we have exploited this difference between the two enzymes to identify the regions of the RT that contribute to the compounds' inhibitory activities.
(16) It may thus represent an artifact of the labeling procedure rather than a novel basophil-derived prostaglandin.
(17) Endothelin-1 (ET-1) is a novel vasoconstricting and cardiotonic peptide that is synthesized by the vascular endothelium.
(18) These observations indicated a novel mechanism that in the absence of light-dark schedule, mothers taught the circadian rhythm to the pups as they raised them.
(19) Pretreatment with a novel CRF antagonist, alpha-helical CRF9-41 (130.9 nmol i.t.v.
(20) Prions are novel, transmissible pathogens causing degenerative diseases of the central nervous system both in humans and in animals.
Unprecedented
Definition:
(a.) Having no precedent or example; not preceded by a like case; not having the authority of prior example; novel; new; unexampled.
Example Sentences:
(1) Anesthesiology residency programs experienced unprecedented growth from 1980 to 1986.
(2) "We have determined that an unprecedented framework has been established, where an organisation that can make decisions at a national level ... will be at the forefront of the investigations," Abe said.
(3) Fine, but the most important new political fact is the unprecedented wave of support that has latched on to Corbyn: the hundreds of thousands who joined Labour, the thumping majority that handed him the leadership, the huge sections of the country that have tuned out of Westminster droid-talk.
(4) Talking ahead of a UN climate summit in Peru next month, Kim said he was alarmed by World Bank-commissioned research from the Potsdam Institute for Climate Impact Research in Germany, which said that as a result of past greenhouse gas emissions the world is condemned to unprecedented weather events.
(5) Such briefings for the entire senate are not unprecedented but it is very rare for them to take place in the White House, which does not have large secure facilities for such classified sessions as Congress.
(6) Mike Ashley’s comment that he wants to make Sports Directhis chain the best employer on the high street behind John Lewis was unprecedented.
(7) Stonehenge stood at the heart of a sprawling landscape of chapels, burial mounds, massive pits and ritual shrines, according to an unprecedented survey of the ancient grounds.
(8) His comments come the day after David Cameron revealed that an unprecedented aerial strike in Syria had killed two Britons fighting alongside Islamic State (Isis).
(9) The "fly on the wall" stuff is no more for the moment but, Andy, grab the opportunities when you can – a few years down the line when Cameron is on the lecture circuit and the rest of us are hanging up our cameras for good, you should have an unprecedented photographic record of a seat of power.
(10) CLIA will require unprecedented coordination and cooperation between the clinical laboratory and ancillary sites.
(11) The recent violence is unprecedented, but this immigration pattern is nothing new.
(12) All of this amounts to an unprecedented opportunity to fix a system that is recognised as broken by the highest levels of government.
(13) Apple held an unprecedented online sale on Friday and retail giants like WalMart have combined their online and bricks and mortar sales.
(14) And, to state the bleedin' obvious, the law seems to be doing its job: unprecedented numbers of journalists and media executives have been arrested, and are being tried or face trial.
(15) There is a global consensus that a changing climate leads to changes in the frequency, intensity, duration and timing of extreme weather and climate events, and can result in unprecedented events.
(16) MR imaging may afford unprecedented diagnostic sensitivity in assessing pharmacologic efficacy in cerebral ischemia.
(17) An unprecedented alliance of business, welfare and environmental groups and trade unions recently demanded an end to Australia’s climate policy paralysis , issuing principles including that Australia be able to buy cheaper international permits, and that greenhouse reductions occur “across all sections of the economy”.
(18) Ian Macfarlane signals frontbench ambition after defecting to Nationals Read more But the deputy leader of the Nationals, Barnaby Joyce, pushed back at the criticism, saying it was not unprecedented for people to move between the Coalition parties and noted it was not as significant as ousting a prime minister.
(19) This was equivalent to nearly nearly half the number rescued last May, a month which saw an unprecedented level of migration in the Mediterranean.
(20) It would have been unprecedented for a large bloc such as the Freedom Caucus to have voted against the party’s choice of nominee, as they had hinted they might do with Webster.