(a.) Binding in law or conscience; imposing duty or obligation; requiring performance or forbearance of some act; -- often followed by on or upon; as, obedience is obligatory on a soldier.
Example Sentences:
(1) It is important to note that the proposed mechanism is not obligatory for androgen or other steroid hormone action.
(2) However, besides these obligatory alterations a high inter- and intraindividual variability of structural aspects is found in MS lesions.
(3) The presence of the other islet cell-types may be obligatory for these appropriate responses.
(4) From the derived cell flux in these compartments we suggest that 1) many more pre-B cells are produced than needed by the peripheral B cell pool; 2) if TdT is an obligatory stage in B cell genesis, there must be at least two cell cycles in the pre-B cell compartment; 3) if it is not, the TdT+ stage may be bypassed, with HIS24+TdT-Ig- cells perhaps feeding directly into the pre-B cell compartment.
(5) Neither cytochrome a nor cytochrome c appears to be an obligatory intermediate in cyanide-sensitive nicotinamide adenine dinucleotide oxidation in B. subtilis.
(6) Thus, the results of this study indicate that retinal is an obligatory intermediate in the hepatic production of retinoic acid from retinol and that cytosolic and microsomal retinol dehydrogenases play a key role in this process.
(7) Thus, even though LPS is a potent inducer of IFN-beta in murine macrophages, class I IFN expression may not be an obligatory intermediate event in the LPS-driven activation of ISRE binding activity.
(8) The four hosts (Mollusc -- Crustacean -- Odonat -- Amphibian) are obligatory in the life cycle for it is impossible to infect the Insects directly with the cecariae or the frog (tadpoles as well as adults) with the mesocercariae.
(9) The synergistic actions of E2 and either AA, the obligatory precursor of PGF2 alpha, or A23187, an enhancer of AA release from phospholipid stores, point to a stimulatory effect of E2 on prostaglandin synthase activity.
(10) No wt-1 expression was detected at any stage of tooth development showing that wt-1 is not obligatory for regulation of Egr-1 expression.
(11) These findings show that class switch by deletion of DNA regions in mature plasma cells is not obligatory for the secretion of immunoglobulin classes other than IgM.
(12) Serotonin plays an obligatory role in the initiation and expression of leech feeding behavior by its differential modulation of central neuronal networks and peripheral glands and muscles.
(13) However, in spite of these similarities, they differentially stimulate estrogenic responses that were previously thought to be interrelated and obligatory for full estrogenic action.
(14) These results, together with data from the native proteins, are consistent with obligatory 1-electron transfer between dehydrogenase and ETF possibly involving the exposed dimethylbenzene edge of ETF.
(15) Although Mg2+ is absolutely required for activation of adenylate cyclase by the GTP analogue guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG), it is not obligatory for p[NH]ppG-stimulated ADP-ribosylation by cholera toxin.
(16) This suggests that normally the midline floor plate cells do provide guidance cues, but that these cues are not obligatory.
(17) The protein supply recommended for a certain age group should not be obligatory for the individual child.
(18) The results strongly suggest that the obligatory antigen processing event required for helper T cell recognition of alloantigen is simply the insertion of the alloantigen into the same membrane bilayer as the syngeneic Ia restricting element.
(19) This new function is derived by assuming that all chromosome arms except the short arms of acrocentric chromosomes hav an obligatory chiasma, and that the remaining chiasmata are distributed at random; assumptions which may correspond reasonably well to reality.
(20) Its somewhat unique features have attracted widespread interest both nationally and internationally and may be seen as part of an international movement towards obligatory CME in Western Medicine.
Oblige
Definition:
(v. t.) To attach, as by a bond.
(v. t.) To constrain by physical, moral, or legal force; to put under obligation to do or forbear something.
(v. t.) To bind by some favor rendered; to place under a debt; hence, to do a favor to; to please; to gratify; to accommodate.
Example Sentences:
(1) However, he has also insisted that North Korea live up to its own commitments, adhere to its international obligations and deal peacefully with its neighbours.
(2) Shorten said any arrangement needed to be consistent with international obligations, with asylum seekers afforded due process and their claims properly assessed.
(3) And this has opened up a loophole for businesses to be morally bankrupt, ignoring the obligations to its workforce because no legal conduct has been established.” Whatever the outcome of the pending lawsuits, it’s unlikely that just one model will work for everybody.
(4) If we’re waiting around for the Democratic version to sail through here, or the Republican version to sail through here, all those victims who are waiting for us to do something will wait for days, months, years, forever and we won’t get anything done.” Senator Bill Nelson, whose home state of Florida is still reeling from the Orlando shooting, said he felt morally obligated to return to his constituents with results.
(5) 45Calcium has been used to compare the kinetics for the transport and bioaccumulation of this regulatory cation in keratinocyte cultures of a kindred with HPS (i.e., one HPS homozygote, one HPS obligate heterozygote, one normal family member, and healthy adult controls).
(6) The department will consider the judgment to see whether it is obliged to rerun the consultation process.
(7) Physicians have an obligation to ensure that parents make a well-considered decision, and to provide them with counsel and support.
(8) As he told us: 'Individual faults and frailties are no excuse to give in and no exemption from the common obligation to give of ourselves.'
(9) Organisms of the genus Bacteroides represent the major group of obligate anaerobes involved in human infections.
(10) Considerations of different ways of obtaining informed consent, determining ways of minimizing harm, and justifications for violating the therapeutic obligation are discussed but found unsatisfactory in many respects.
(11) As commander in chief, I believe that taking care of our veterans and their families is a sacred obligation.
(12) A 20% discount will save the average first-time buyer £43,000 on a £218,000 home (the average cost paid by such buyers), which would leave a revenue shortfall of £8bn from income if current regulatory obligations had been retained on the 200,000 homes.
(13) Justice Hiley later suggested the conduct required by a doctor outside of his profession, as Chapman was describing it, was perhaps a “broad generality” and not specific enough “to create an ethical obligation.” “It’s no broader than the Hippocratic oath,” Chapman said in her reply.
(14) Asked by Marr if he knew if Ashcroft paid tax in this country, Hague said:" I'm sure he fulfils the obligations that were imposed on him at the time he became …" Marr: "Have you asked him?"
(15) These species are all obligately anaerobic, asaccharolytic, and generally nonreactive, and they grow poorly and slowly on media commonly used to isolate anaerobic bacteria.
(16) According to Swedish law, couples who are planning to marry are obliged to publish their address.
(17) In the present report we summarize our data on 144 obligate female carriers.
(18) But whether it arose from religious belief, from a noblesse oblige or from a sense of solidarity, duty in Britain has been, to most people, the foundation of rights rather than their consequence.
(19) No serious side effects were reported and none of the patients was obliged to terminate treatment because of side effects.
(20) This paper argues that although this is true of some types of obligation, including the ones discussed by Professor Kluge, it is by no means true of all.