(a.) Binding in law or conscience; imposing duty or obligation; requiring performance or forbearance of some act; -- often followed by on or upon; as, obedience is obligatory on a soldier.
Example Sentences:
(1) It is important to note that the proposed mechanism is not obligatory for androgen or other steroid hormone action.
(2) However, besides these obligatory alterations a high inter- and intraindividual variability of structural aspects is found in MS lesions.
(3) The presence of the other islet cell-types may be obligatory for these appropriate responses.
(4) From the derived cell flux in these compartments we suggest that 1) many more pre-B cells are produced than needed by the peripheral B cell pool; 2) if TdT is an obligatory stage in B cell genesis, there must be at least two cell cycles in the pre-B cell compartment; 3) if it is not, the TdT+ stage may be bypassed, with HIS24+TdT-Ig- cells perhaps feeding directly into the pre-B cell compartment.
(5) Neither cytochrome a nor cytochrome c appears to be an obligatory intermediate in cyanide-sensitive nicotinamide adenine dinucleotide oxidation in B. subtilis.
(6) Thus, the results of this study indicate that retinal is an obligatory intermediate in the hepatic production of retinoic acid from retinol and that cytosolic and microsomal retinol dehydrogenases play a key role in this process.
(7) Thus, even though LPS is a potent inducer of IFN-beta in murine macrophages, class I IFN expression may not be an obligatory intermediate event in the LPS-driven activation of ISRE binding activity.
(8) The four hosts (Mollusc -- Crustacean -- Odonat -- Amphibian) are obligatory in the life cycle for it is impossible to infect the Insects directly with the cecariae or the frog (tadpoles as well as adults) with the mesocercariae.
(9) The synergistic actions of E2 and either AA, the obligatory precursor of PGF2 alpha, or A23187, an enhancer of AA release from phospholipid stores, point to a stimulatory effect of E2 on prostaglandin synthase activity.
(10) No wt-1 expression was detected at any stage of tooth development showing that wt-1 is not obligatory for regulation of Egr-1 expression.
(11) These findings show that class switch by deletion of DNA regions in mature plasma cells is not obligatory for the secretion of immunoglobulin classes other than IgM.
(12) Serotonin plays an obligatory role in the initiation and expression of leech feeding behavior by its differential modulation of central neuronal networks and peripheral glands and muscles.
(13) However, in spite of these similarities, they differentially stimulate estrogenic responses that were previously thought to be interrelated and obligatory for full estrogenic action.
(14) These results, together with data from the native proteins, are consistent with obligatory 1-electron transfer between dehydrogenase and ETF possibly involving the exposed dimethylbenzene edge of ETF.
(15) Although Mg2+ is absolutely required for activation of adenylate cyclase by the GTP analogue guanosine 5'-[beta gamma-imido]triphosphate (p[NH]ppG), it is not obligatory for p[NH]ppG-stimulated ADP-ribosylation by cholera toxin.
(16) This suggests that normally the midline floor plate cells do provide guidance cues, but that these cues are not obligatory.
(17) The protein supply recommended for a certain age group should not be obligatory for the individual child.
(18) The results strongly suggest that the obligatory antigen processing event required for helper T cell recognition of alloantigen is simply the insertion of the alloantigen into the same membrane bilayer as the syngeneic Ia restricting element.
(19) This new function is derived by assuming that all chromosome arms except the short arms of acrocentric chromosomes hav an obligatory chiasma, and that the remaining chiasmata are distributed at random; assumptions which may correspond reasonably well to reality.
(20) Its somewhat unique features have attracted widespread interest both nationally and internationally and may be seen as part of an international movement towards obligatory CME in Western Medicine.
Required
Definition:
(imp. & p. p.) of Require
Example Sentences:
(1) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(2) Patients with normal echocardiogram and ECG on admission do not require intensive care monitoring.
(3) More than 2 months after the combined treatment were required for the suppression.
(4) It involves creativity, understanding of art form and the ability to improvise in the highly complex environment of a care setting.” David Cameron has boosted dementia awareness but more needs to be done Read more She warns: “To effect a cultural change in dementia care requires a change of thinking … this approach is complex and intricate, and can change cultural attitudes by regarding the arts as central to everyday life of the care home.” Another participant, Mary*, a former teacher who had been bedridden for a year, read plays with the reminiscence arts practitioner.
(5) Blatter requires a two-thirds majority of the 209 voters to triumph in the opening round, with a simple majority required if it goes to a second round.
(6) In platform shoes to emulate Johnson's height, and with the aid of prosthetic earlobes, Cranston becomes the 36th president: he bullies and cajoles, flatters and snarls and barks, tells dirty jokes or glows with idealism as required, and delivers the famous "Johnson treatment" to everyone from Martin Luther King to the racist Alabama governor George Wallace.
(7) Even so, amputation of fifteen extremities and four other major excisions were required in twelve patients.
(8) However, its identity requires further characterization.
(9) Past imaging techniques shown in the courtroom have made the conventional rules of evidence more difficult because of the different informational content and format required for presentation of these data.
(10) Further studies are required to elucidate specific roles of the steroid-induced proteins in the effects of glucocorticoids on HTM and HS cells.
(11) As the requirements to store and display these images increase, the following questions become important: (a) What methods can be used to ensure that information given to the physician represents the originally acquired data?
(12) Maximal covalent binding of [4,5-14C]ronidazole to DNA also required four-electron reduction, consistent with previous studies of the covalent binding of this agent to immobilized sulfhydryl groups [Kedderis et al.
(13) Most patients of the bopindolol-group needed 1 mg once daily as compared to those on the nifedipine who required 20 mg b.i.d.
(14) Throughout the period of rehabilitation, the frequent changes of a patient's condition may require a process of ongoing evaluation and appropriate adjustments in the physical therapy program.
(15) Breast reconstruction should not be limited to the requiring patients, but should represent, in selected cases with favourable prognosis, an integrative and complementary procedure of the treatment.
(16) A domain containing a CA repeat, similar to ones found in other late, cAMP-induced Dictyostelium genes, is required for cAMP-induced and developmental expression.
(17) Many problems at the macroscopic level require clarification of how an animal uses a compartment of suite of muscles and whether morphological differences reflect functional ones.
(18) Although the longest period required for resolving weakness was three days, the MRI, the CT and the electroencephalogram revealed no significant abnormality.
(19) T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation.
(20) In contrast, HEL antigen requires metabolically active cells for both of these processes.