What's the difference between observation and protocol?

Observation


Definition:

  • (n.) The act or the faculty of observing or taking notice; the act of seeing, or of fixing the mind upon, anything.
  • (n.) The result of an act, or of acts, of observing; view; reflection; conclusion; judgment.
  • (n.) Hence: An expression of an opinion or judgment upon what one has observed; a remark.
  • (n.) Performance of what is prescribed; adherence in practice; observance.
  • (n.) The act of recognizing and noting some fact or occurrence in nature, as an aurora, a corona, or the structure of an animal.
  • (n.) Specifically, the act of measuring, with suitable instruments, some magnitude, as the time of an occultation, with a clock; the right ascension of a star, with a transit instrument and clock; the sun's altitude, or the distance of the moon from a star, with a sextant; the temperature, with a thermometer, etc.
  • (n.) The information so acquired.

Example Sentences:

  • (1) The patterns observed were: clusters of granules related to the cell membrane; positive staining localized to portions of the cell membrane, and, less commonly, the whole cell circumference.
  • (2) However, this deficit was observed only when the sample-place preceded but not when it followed the interpolated visits (second experiment).
  • (3) In conclusion, in S-rats a glucose-stimulated insulin release is accompanied by an increase in IBF, but this is not observed in P-rats.
  • (4) The combined immediate and delayed responses to fleas in the dog are as observed by other investigators in man and guinea pigs.
  • (5) However, when cross-linked to anti-CD4 or anti-CD8 antibodies a markedly enhanced proliferation of the corresponding subpopulation is observed.
  • (6) Using monoclonal antibodies directed against the plasma membrane of Madin-Darby canine kidney (MDCK) cells, we demonstrated previously that a glycoprotein with an Mr = 23,000 (gp23) had a non-polarized cell surface distribution and was observed on both the apical and basolateral membranes (Ojakian, G. K., Romain, R. E., and Herz, R. E. (1987) Am.
  • (7) Stimulation is also observed with mixtures of APC expressing DPw3 and APC expressing A1, and likewise, DPw3+ APC become stimulatory when preincubated with supernatants from A1-positive cells.
  • (8) For this reason, these observations should not be disregarded.
  • (9) No differences between the two substances were observed with respect to side effects and general tolerability.
  • (10) The testing of other models and their failure to describe the kinetic observations are discussed.
  • (11) The extrusion of granules into the intercellular space via exocytosis is frequently observed.
  • (12) The time of observation varied between 2 and 17 years.
  • (13) Insensitive variants die more slowly than wild type cells, with 10-20% cell death observed within 24 h after addition of dexamethasone.
  • (14) The subcellular distribution of sialyltransferase and its product of action, sialic acid, was investigated in the undifferentiated cells of the rat intestinal crypts and compared with the pattern observed in the differentiated cells present in the surface epithelium.
  • (15) No reaction product was observed in the lamellar areas.
  • (16) Cyanoacrylate and PDS coatings were not detectable after 6 weeks while PHBA and PLLA coatings were still observed after 48 weeks.
  • (17) A total of 13 ascertainments of folate sensitive autosomal fragile sites is observed, of which 10q23 fragility appears to be the most frequent.
  • (18) This new observation offers good possibilities to study the metabolism of tryptophan at the cellular level.
  • (19) These membrane perturbation effects not observed with bleomycin-iron in the presence of a hydroxyl radical scavenger, dimethyl thiourea, or a chelating agent, desferrioxamine, were correlated with the ability of the complex to generate highly reactive oxygen species.
  • (20) The fluctuations in [Ca2+]i measured with fura-2 were synchronized among the population of cells observed and were sensitive to extracellular Ca2+ concentration ([Ca2+]o).

Protocol


Definition:

  • (n.) The original copy of any writing, as of a deed, treaty, dispatch, or other instrument.
  • (n.) The minutes, or rough draught, of an instrument or transaction.
  • (n.) A preliminary document upon the basis of which negotiations are carried on.
  • (n.) A convention not formally ratified.
  • (n.) An agreement of diplomatists indicating the results reached by them at a particular stage of a negotiation.
  • (v. t.) To make a protocol of.
  • (v. i.) To make or write protocols, or first draughts; to issue protocols.

Example Sentences:

  • (1) In addition, this pretreatment protocol did not modify the recipient immune response against B-lymphocyte alloantigens which developed in unsuccessful transplants.
  • (2) An effective graft-surveillance protocol needs to be applicable to all patients; practical in terms of time, effort, and cost; reliable; and able to detect, grade, and assess progression of lesions.
  • (3) Participants (n=165) entering a week-long outpatient education program completed a protocol measuring self-care patterns, glycosylated hemoglobin levels, and emotional well-being.
  • (4) Two cases with primary Carcinoma in situ (Cis) were treated with the same protocol.
  • (5) However, there was no consistent protocol for the method or duration of drug administration.
  • (6) Survival was independent of the type of clinical presentation and protocol employed but was correlated with the stage (P less than 0.0005), symptoms (P less than 0.025), bulky disease (P less than 0.025) and bone marrow involvement (P less than 0.025).
  • (7) This new protocol has increased the effectiveness of the toxicology laboratory and enhanced the efficiency of the house staff.
  • (8) Our results on humoral and cellular components of immunity in dependence of age, according to SENIEUR protocol admission criteria are presented.
  • (9) Based upon our clinical experience and this review of the literature, a suggested management protocol is presented.
  • (10) A standard protocol is reported for the highly efficient demonstration of replication patterns corresponding to R-type and G-type banding.
  • (11) Three-year and short-term instillation protocols were compared with each other and with the combination of the two.
  • (12) The use of a major pancreatic resection for the surgical management of necrotizing pancreatitis should be excluded from treatment protocols.
  • (13) We conclude that, whereas an identical protocol of acute ND had no significant effects on diaphragm muscle structure and function in adult rats, adolescent animals exhibit significantly less nutritional reserve.
  • (14) We outline a protocol for presenting the diagnosis of pseudoseizure with the goal of conveying to the patient the importance of knowing the nonepileptic nature of the spells and the need for psychiatric follow-up.
  • (15) The protocols which were developed in these studies also provide an effective maneuver for tumor-specific immunotherapy.
  • (16) In a previous report dealing with the guanidine hydrochloride protocol for the extraction of RNA from mouse peritoneal macrophages, we identified a major source of RNA-degrading activity and showed that its removal early in the extraction procedure resulted in a more dependable method for the recovery of high-quality RNA.
  • (17) Various protocols were employed to induce LTP and were deemed successful as evaluated by recording sustained enhancement of the mean peak amplitude of conventionally elicited large compound EPSPs and extracellular field potentials.
  • (18) This is the final report of the Phase I Protocol for the initial clinical study of Multiple Dose WR-2721 with radiotherapy (RTOG 80-02).
  • (19) This paper evaluates 94 patients with AAF and 462 patients with GBM treated with radiation therapy with or without BCNU on 3 consecutive randomized protocols of the Radiation Therapy Oncology Group (RTOG) between 1974 and 1983.
  • (20) The patients were included in a protocol including orthopedic and US controls.