(superl.) Not young; advanced far in years or life; having lived till toward the end of the ordinary term of living; as, an old man; an old age; an old horse; an old tree.
(superl.) Not new or fresh; not recently made or produced; having existed for a long time; as, old wine; an old friendship.
(superl.) Formerly existing; ancient; not modern; preceding; original; as, an old law; an old custom; an old promise.
(superl.) Continued in life; advanced in the course of existence; having (a certain) length of existence; -- designating the age of a person or thing; as, an infant a few hours old; a cathedral centuries old.
(superl.) Long practiced; hence, skilled; experienced; cunning; as, an old offender; old in vice.
(superl.) Long cultivated; as, an old farm; old land, as opposed to new land, that is, to land lately cleared.
(superl.) Worn out; weakened or exhausted by use; past usefulness; as, old shoes; old clothes.
(superl.) More than enough; abundant.
(superl.) Aged; antiquated; hence, wanting in the mental vigor or other qualities belonging to youth; -- used disparagingly as a term of reproach.
(superl.) Old-fashioned; wonted; customary; as of old; as, the good old times; hence, colloquially, gay; jolly.
(superl.) Used colloquially as a term of cordiality and familiarity.
Example Sentences:
(1) A 2.5-month-old child with cyanotic heart disease who required long-term PGE1 infusions; developed widespread periosteal reactions during the course of therapy.
(2) Yet the Tory promise of fiscal rectitude prevailed in England Alexander had been in charge of Labour’s election strategy, but he could not strategise a victory over a 20-year-old Scottish nationalist who has not yet taken her finals.
(3) A 61-year-old man experienced four bouts of pancreatitis in 1 year.
(4) A total of 104 evaluable patients 20-90 years old treated by direct vision internal urethrotomy a.m. Sachse for urethral strictures reported retrospectively via a questionnaire their sexual potency before and after internal urethrotomy.
(5) A 66-year-old woman with acute idiopathic polyneuritis (Landry-Guillain-Barré [LGB] syndrome) had normal extraocular movements, but her pupils did not react to light or accommodation.
(6) Scatchard analyses of binding data obtained with synaptosomal preparations from 17-day-old embryos revealed two T3 binding sites.
(7) A remarkable deterioration of prognosis with increasing age rises the question whether treatment with cytotoxic drugs should be tried in patients more than 60 years old.
(8) A specimen of a very early ovum, 4 to 6 days old, shown in the luminal form of imbedding before any hemorrhage has taken place, confirms that the luminal form of imbedding does occur.
(9) Data collection at the old hospital for comparison, however, was not always reliable.
(10) A leg ulcer in a 52-year-old renal transplant patient yielded foamy histiocytes containing acid-fast bacilli subsequently identified as a Runyon group III Mycobacterium.
(11) The 36-year-old teacher at an inner-city London primary school earns £40,000 a year and contributes £216 a month to her pension.
(12) Eight-week-old virgin untreated female mice were induced to ovulate using equine chorionic gonadotropin (eCG) and human chorionic gonadotropin (hCG), and were then caged with males overnight.
(13) The authors report an ocular luxation of a four-year-old girl after a bicycle accident.
(14) Peak incidence is found among 40 to 49-year-old and 60 to 64-year-old women.
(15) The capillary-adipocyte distances were shorter and the vascularization density was higher in old rats.
(16) Brilliant, old-fashioned speech, from the days before teleprompters became all-dominant.
(17) Though the 54-year-old designer made brief returns to the limelight after his fall from grace, designing a one-off collection for Oscar de la Renta last year , his appointment at Margiela marks a more permanent comeback.
(18) He also deals with the incidence, conservative and surgical treatment of osteo-arthrosis in old age and with the possibilities of its prevention.
(19) Sterile, pruritic papules and papulopustules that formed annular rings developed on the back of a 58-year-old woman.
(20) The first patient, an 82-year-old woman, developed a WPW syndrome suggesting posterior right ventricular preexcitation, a pattern which persisted for four months until her death.
Senescent
Definition:
(a.) Growing old; decaying with the lapse of time.
Example Sentences:
(1) The proliferation of this cell type may represent an escape from the senescence pathway and progression to immortal tumor cells.
(2) In senescent rats, however, the proportions of salt-soluble and detergent-soluble AChE may differ from those in young rats.
(3) In addition, we have shown that long-lived, presumably non-senescent, strains do not arise by suppressor mutation, but lose senescence plasmid DNA by another mechanism.
(4) Senescent (26-28 months) Fischer 344 rats were shown to have a lower density of D2 sites (-36%) without any change in affinity in membranes prepared from homogenized caudate-putamen (CPU), as compared to young adult (5-6 months) rats.
(5) The cell cycle-dependent changes in the transglutaminase mRNA levels strongly support the implicated involvement of the enzyme in cell growth, differentiation, and senescence.
(6) The increased levels of HK1 could affect other erythrocyte metabolic pathways slowing down the physiological rate of cellular senescence and result in increased activity levels of other cell-age-dependent enzymes.
(7) Advancing age was associated with a reduction in cell proliferative responses to PHA in both substrains, although the rate of decline was significantly more rapid in the senescence-prone animals.
(8) Instead of degenerative changes, these results show an activation of the vasopressinergic system in senescence and in SDAT patients, similar to earlier observations in the aged rat and in accordance with a rise in human neurophysin and VP levels reported recently.
(9) Thus, constitutive expression of specific cytochrome P450 genes is repressed or activated in senescent rats.
(10) Mild daily exercise, maintained throughout adult life into early senescence, attenuates muscle atrophy and promotes adaptive enzymatic changes in atrophying muscles.
(11) A second set of experiments which involved the injection of E2 into senescent male as well as female rats indicated that there were no sex differences in improvements in inclined screen performance, and that once the E2 injections were discontinued, performance returned to preadministration levels.
(12) Additionally, analysis of the multiple steps occurring in the El cultures, as well as in the emergence of the continuous cell lines, could potentially elucidate the processes occurring during human epithelial cell carcinogenesis and escape from senescence.
(13) Significant anamnestic SIgA responses were shown after oral immunization with DNP-BGG in adult rats, but was not observed in the senescent and midlife (10-12 months) rats.
(14) Modulation of cellular senescence by growth factors, hormones, and genetic manipulation is contrasted, but newer studies in oncogene involvement are omitted.
(15) Under the same conditions, PM from senescent mice generated 62% of the initial O2- produced in response to zymosan, and 45% in response to OZ.
(16) Untreated cells, or cells treated with MCA or TPA only, usually became senescent around 6-8 weeks after plating and died, but those treated with both MCA and TPA became immortalised and underwent transformation to a phenotype capable of growth in soft agar.
(17) Because immune senescence most profoundly affects T lymphocyte functions, we suspected that LIA production would decline with age.
(18) Abnormal granular structures, which stained positively with periodic acid-Schiff (PAS-positive granular structures; PGS), were observed in the brain of senescence accelerated mouse (SAM).
(19) In senescent females the number of small IMPs was decreased in the perikarya and dendritic shafts compared to young females while the number of large particles was increased in the outer leaflet of the membrane of dendritic shafts, reaching values similar to those observed in males.
(20) Our data suggest that the release of u-PA antigen by human macrovascular endothelial cells can be used as an indicator of cell senescence.