(a.) Free of access; not shut up; not closed; affording unobstructed ingress or egress; not impeding or preventing passage; not locked up or covered over; -- applied to passageways; as, an open door, window, road, etc.; also, to inclosed structures or objects; as, open houses, boxes, baskets, bottles, etc.; also, to means of communication or approach by water or land; as, an open harbor or roadstead.
(a.) Free to be used, enjoyed, visited, or the like; not private; public; unrestricted in use; as, an open library, museum, court, or other assembly; liable to the approach, trespass, or attack of any one; unprotected; exposed.
(a.) Free or cleared of obstruction to progress or to view; accessible; as, an open tract; the open sea.
(a.) Not drawn together, closed, or contracted; extended; expanded; as, an open hand; open arms; an open flower; an open prospect.
(a.) Without reserve or false pretense; sincere; characterized by sincerity; unfeigned; frank; also, generous; liberal; bounteous; -- applied to personal appearance, or character, and to the expression of thought and feeling, etc.
(a.) Not concealed or secret; not hidden or disguised; exposed to view or to knowledge; revealed; apparent; as, open schemes or plans; open shame or guilt.
(a.) Not of a quality to prevent communication, as by closing water ways, blocking roads, etc.; hence, not frosty or inclement; mild; -- used of the weather or the climate; as, an open season; an open winter.
(a.) Not settled or adjusted; not decided or determined; not closed or withdrawn from consideration; as, an open account; an open question; to keep an offer or opportunity open.
(a.) Free; disengaged; unappropriated; as, to keep a day open for any purpose; to be open for an engagement.
(a.) Uttered with a relatively wide opening of the articulating organs; -- said of vowels; as, the an far is open as compared with the a in say.
(a.) Uttered, as a consonant, with the oral passage simply narrowed without closure, as in uttering s.
(a.) Not closed or stopped with the finger; -- said of the string of an instrument, as of a violin, when it is allowed to vibrate throughout its whole length.
(a.) Produced by an open string; as, an open tone.
(n.) Open or unobstructed space; clear land, without trees or obstructions; open ocean; open water.
(v. t.) To make or set open; to render free of access; to unclose; to unbar; to unlock; to remove any fastening or covering from; as, to open a door; to open a box; to open a room; to open a letter.
(v. t.) To spread; to expand; as, to open the hand.
(v. t.) To disclose; to reveal; to interpret; to explain.
(v. t.) To make known; to discover; also, to render available or accessible for settlements, trade, etc.
(v. t.) To enter upon; to begin; as, to open a discussion; to open fire upon an enemy; to open trade, or correspondence; to open a case in court, or a meeting.
(v. t.) To loosen or make less compact; as, to open matted cotton by separating the fibers.
(v. i.) To unclose; to form a hole, breach, or gap; to be unclosed; to be parted.
(v. i.) To expand; to spread out; to be disclosed; as, the harbor opened to our view.
(v. i.) To begin; to commence; as, the stock opened at par; the battery opened upon the enemy.
(v. i.) To bark on scent or view of the game.
Example Sentences:
(1) says Gregg Wallace opening the new series of Celebrity MasterChef (Mon-Fri, 2.15pm, BBC1).
(2) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
(3) His son, Karim Makarius, opened the gallery to display some of the legacy bequeathed to him by his father in 2009, as well as the work of other Argentine photographers and artists – currently images by contemporary photographer Facundo de Zuviria are also on show.
(4) Blatter requires a two-thirds majority of the 209 voters to triumph in the opening round, with a simple majority required if it goes to a second round.
(5) Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial.
(6) By hybridization studies, three plasmids in two forms (open circular and supercoiled) were detected in the strain A24.
(7) It is the only fully-fledged casino to open in the region, outside Lebanon.
(8) Sixty-six patients were followed for 12 months in an open safety study.
(9) The PUP founder made the comments at a voters’ forum and press conference during an open day held at his Palmer Coolum Resort, where he invited the electorate to see his giant robotic dinosaur park, memorabilia including his car collection and a concert by Dean Vegas, an Elvis impersonator.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) An opening wedge osteotomy is then directed posterior-dorsal to anterior-plantar, to effectively plantarflex the posterior aspect of the calcaneus.
(12) … or a theatre and concert hall There are a total of 16 ghost stations on the Paris metro; stops that were closed or never opened.
(13) The decline in the frequency of serious complications was primarily due to a decrease in the proportion of patients with open fractures treated with plate osteosynthesis from nearly 50% to 19%.
(14) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(15) 'The French see it as an open and shut case,' says a Paris-based diplomat.
(16) The White House denied there had been an agreement, but said it was open in principle to such negotations.
(17) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(18) The data indicate greater legitimacy and openness in discussing holocaust-related issues in the homes of ex-partisans than in the homes of ex-prisoners in concentration camps.
(19) He also plans to build a processing facility where tourists can gain firsthand experience of the fisheries industry, and to open a restaurant.
(20) He had been just asked to open their new town hall, in the hope he might donate a Shakespeare statue.
Profound
Definition:
(a.) Descending far below the surface; opening or reaching to a great depth; deep.
(a.) Intellectually deep; entering far into subjects; reaching to the bottom of a matter, or of a branch of learning; thorough; as, a profound investigation or treatise; a profound scholar; profound wisdom.
(a.) Characterized by intensity; deeply felt; pervading; overmastering; far-reaching; strongly impressed; as, a profound sleep.
(a.) Bending low, exhibiting or expressing deep humility; lowly; submissive; as, a profound bow.
(n.) The deep; the sea; the ocean.
(n.) An abyss.
(v. t.) To cause to sink deeply; to cause to dive or penetrate far down.
(v. i.) To dive deeply; to penetrate.
Example Sentences:
(1) With profound blockade, the slope of the edrophonium dose-response relationship was significantly flatter (P less than 0.05) than that of neostigmine.
(2) Cadavers have a multitude of possible uses--from the harvesting of organs, to medical education, to automotive safety testing--and yet their actual utilization arouses profound aversion no matter how altruistic and beneficial the motivation.
(3) Our positive experiences with IMACS discussed above should be even more profound and profitable for the larger medical institutions.
(4) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(5) About one out of three profoundly deaf children has an autosomal recessive form of inherited deafness.
(6) This continuing influence of Nazi medicine raises profound questions for the epistemology and morality of medicine.
(7) However six equivocal studies were observed in profoundly jaundiced patients with bilirubin levels above 400 mumol l-1 due to difficulties in differentiating extrahepatic obstruction from severe intrahepatic cholestasis.
(8) After a 2-day incubation with IL-4, expression of IL-2R p55 was markedly induced, but expression of IL2-R p70-75 was profoundly suppressed in a dose-dependent manner.
(9) "For those people who are able to use the laws, the change is profound."
(10) Most striking finding was his difficulty in identifying common objects and colours along with a profound alexia.
(11) This BOA technique was used to test the hearing of 82 profoundly involved handicapped children.
(12) These tools will allow us to manipulate the mammalian immune response in a variety of different ways that will have a profound impact both on our understanding of immunology and on medicine in the future.
(13) Based on the fact that all hibernators, at their regulated minimal body temperature, display a uniform turnover rate, related to body weight, the hypothesis is developed that cold tolerance of mammals is generally limited by a common specific minimal metabolic rate, which larger organisms, because of their lower basal metabolism, already attain in less profound hypothermia.
(14) Insulin-like growth factor II (IGF-II) is present at high levels in fetal and early neonatal rat plasma, and decreases profoundly following birth.
(15) The reduction in level of activity and adverse changes in body composition caused by SCI have profound metabolic consequences that may influence the progression and severity of coronary artery disease.
(16) The case of a 32-year-old man who suffered a blow to his left supraorbital region and eyebrow in an automatic closing door is reported to draw attention to the uncommon but trivial nature of this injury which may result in profound visual loss.
(17) In the paper life-threatening diseases which may be accompanied by profound unconsciousness are explained from the laboratory-chemical point of view.
(18) However pneumonia to PC points to a poor prognosis because they are always associated with a profound deficit or cellular immunity.
(19) Thus, it is possible that the loss of these dendritic cells may contribute to the profound immunological abnormalities seen in AIDS.
(20) They produce a more profound effect on clinical and biochemical aspects of rheumatoid arthritis than do the aspirin-like non steroidals.