(a.) Free of access; not shut up; not closed; affording unobstructed ingress or egress; not impeding or preventing passage; not locked up or covered over; -- applied to passageways; as, an open door, window, road, etc.; also, to inclosed structures or objects; as, open houses, boxes, baskets, bottles, etc.; also, to means of communication or approach by water or land; as, an open harbor or roadstead.
(a.) Free to be used, enjoyed, visited, or the like; not private; public; unrestricted in use; as, an open library, museum, court, or other assembly; liable to the approach, trespass, or attack of any one; unprotected; exposed.
(a.) Free or cleared of obstruction to progress or to view; accessible; as, an open tract; the open sea.
(a.) Not drawn together, closed, or contracted; extended; expanded; as, an open hand; open arms; an open flower; an open prospect.
(a.) Without reserve or false pretense; sincere; characterized by sincerity; unfeigned; frank; also, generous; liberal; bounteous; -- applied to personal appearance, or character, and to the expression of thought and feeling, etc.
(a.) Not concealed or secret; not hidden or disguised; exposed to view or to knowledge; revealed; apparent; as, open schemes or plans; open shame or guilt.
(a.) Not of a quality to prevent communication, as by closing water ways, blocking roads, etc.; hence, not frosty or inclement; mild; -- used of the weather or the climate; as, an open season; an open winter.
(a.) Not settled or adjusted; not decided or determined; not closed or withdrawn from consideration; as, an open account; an open question; to keep an offer or opportunity open.
(a.) Free; disengaged; unappropriated; as, to keep a day open for any purpose; to be open for an engagement.
(a.) Uttered with a relatively wide opening of the articulating organs; -- said of vowels; as, the an far is open as compared with the a in say.
(a.) Uttered, as a consonant, with the oral passage simply narrowed without closure, as in uttering s.
(a.) Not closed or stopped with the finger; -- said of the string of an instrument, as of a violin, when it is allowed to vibrate throughout its whole length.
(a.) Produced by an open string; as, an open tone.
(n.) Open or unobstructed space; clear land, without trees or obstructions; open ocean; open water.
(v. t.) To make or set open; to render free of access; to unclose; to unbar; to unlock; to remove any fastening or covering from; as, to open a door; to open a box; to open a room; to open a letter.
(v. t.) To spread; to expand; as, to open the hand.
(v. t.) To disclose; to reveal; to interpret; to explain.
(v. t.) To make known; to discover; also, to render available or accessible for settlements, trade, etc.
(v. t.) To enter upon; to begin; as, to open a discussion; to open fire upon an enemy; to open trade, or correspondence; to open a case in court, or a meeting.
(v. t.) To loosen or make less compact; as, to open matted cotton by separating the fibers.
(v. i.) To unclose; to form a hole, breach, or gap; to be unclosed; to be parted.
(v. i.) To expand; to spread out; to be disclosed; as, the harbor opened to our view.
(v. i.) To begin; to commence; as, the stock opened at par; the battery opened upon the enemy.
(v. i.) To bark on scent or view of the game.
Example Sentences:
(1) says Gregg Wallace opening the new series of Celebrity MasterChef (Mon-Fri, 2.15pm, BBC1).
(2) Open field behaviors and isolation-induced aggression were reduced by anxiolytics, at doses which may be within the sedative-hypnotic range.
(3) His son, Karim Makarius, opened the gallery to display some of the legacy bequeathed to him by his father in 2009, as well as the work of other Argentine photographers and artists – currently images by contemporary photographer Facundo de Zuviria are also on show.
(4) Blatter requires a two-thirds majority of the 209 voters to triumph in the opening round, with a simple majority required if it goes to a second round.
(5) Clonazepam was added to the treatment of patients with poorly controlled epilepsy in a double-blind trial and an open trial.
(6) By hybridization studies, three plasmids in two forms (open circular and supercoiled) were detected in the strain A24.
(7) It is the only fully-fledged casino to open in the region, outside Lebanon.
(8) Sixty-six patients were followed for 12 months in an open safety study.
(9) The PUP founder made the comments at a voters’ forum and press conference during an open day held at his Palmer Coolum Resort, where he invited the electorate to see his giant robotic dinosaur park, memorabilia including his car collection and a concert by Dean Vegas, an Elvis impersonator.
(10) The purpose of the present study was to analyze the effects of cromakalim (BRL 34915), a potent drug from a new class of drugs characterized as "K+ channel openers", on the electrical activity of human skeletal muscle.
(11) An opening wedge osteotomy is then directed posterior-dorsal to anterior-plantar, to effectively plantarflex the posterior aspect of the calcaneus.
(12) … or a theatre and concert hall There are a total of 16 ghost stations on the Paris metro; stops that were closed or never opened.
(13) The decline in the frequency of serious complications was primarily due to a decrease in the proportion of patients with open fractures treated with plate osteosynthesis from nearly 50% to 19%.
(14) At 100 microM-ACh the apparent open time became shorter probably due to channel blockade by ACh molecules.
(15) 'The French see it as an open and shut case,' says a Paris-based diplomat.
(16) The White House denied there had been an agreement, but said it was open in principle to such negotations.
(17) The following model is suggested: exogenous ATP interacts with a membrane receptor in the presence of Ca2+, a cascade of events occurs which mobilizes intracellular calcium, thereby increasing the cytosolic free Ca2+ concentration which consequently opens the calcium-activated K+ channels, which then leads to a change in membrane potential.
(18) The data indicate greater legitimacy and openness in discussing holocaust-related issues in the homes of ex-partisans than in the homes of ex-prisoners in concentration camps.
(19) He also plans to build a processing facility where tourists can gain firsthand experience of the fisheries industry, and to open a restaurant.
(20) He had been just asked to open their new town hall, in the hope he might donate a Shakespeare statue.
Topic
Definition:
(n.) One of the various general forms of argument employed in probable as distinguished from demonstrative reasoning, -- denominated by Aristotle to`poi (literally, places), as being the places or sources from which arguments may be derived, or to which they may be referred; also, a prepared form of argument, applicable to a great variety of cases, with a supply of which the ancient rhetoricians and orators provided themselves; a commonplace of argument or oratory.
(n.) A treatise on forms of argument; a system or scheme of forms or commonplaces of argument or oratory; as, the Topics of Aristotle.
(n.) An argument or reason.
(n.) The subject of any distinct portion of a discourse, or argument, or literary composition; also, the general or main subject of the whole; a matter treated of; a subject, as of conversation or of thought; a matter; a point; a head.
(n.) An external local application or remedy, as a plaster, a blister, etc.
(a.) Topical.
Example Sentences:
(1) Furthermore, all of the sera from seven other patients with shock reactions following the topical application of chlorhexidine preparation also showed high RAST counts.
(2) Topical and systemic antibiotic therapy is common in dermatology, yet it is hard to find a rationale for a particular route in some diseases.
(3) Community involvement is a key element of the Primary Health Care (PHC) approach, and thus an essential topic on a course for managers of Primary Health Care programmes.
(4) The discussion on topics like post-schooling and rehabilitation of motorists has intensified the contacts between advocates of traffic law and traffic psychologists in the last years.
(5) Eighty micrograms of the topically active parasympatholytic drug ipratropium were applied intranasally four times daily in 20 adults with perennial rhinitis and severe watery rhinorrhoea in a double-blind controlled cross-over trial.
(6) Health information dissemination is severely complicated by the widespread stigma associated with digestive topics, manifested in the American public's general discomfort in communicating with others about digestive health.
(7) Female CD-1 mice were initiated with 200 nmol 7,12-dimethylbenz[a] anthracene and topically promoted three times weekly for 20 weeks with doses of 25, 50, 100, or 200 nmol mirex.
(8) This study compares the effects of 60 minutes of ischemic arrest with profound topical hypothermia (10 dogs) on myocardial (1) blood flow and distribution (microspheres), (2) metabolism (oxygen and lactate), (3) water content (wet to dry weights), (4) compliance (intraventricular balloon), and (5) performance (isovolumetric function curves) with 180 minutes of cardiopulmonary bypass with the heart in the beating empty state (seven dogs).
(9) "This will obviously be a sensitive topic for the US administration, but partners in the transatlantic alliance must be clear on common rules of engagement in times of conflict if we are to retain any moral standing in the world," Verhofstadt said.
(10) The decision of the editors to solicit a review for the Medical Progress series of this journal devoted to current concepts of the renal handling of salt and water is sound in that this important topic in kidney physiology has recently been the object of a number of new, exciting and, in some instances, quite unexpected insights into the mechanisms governing sodium excretion.
(11) The tetracaine component of TAC is superfluous for obtaining topical anesthesia of minor dermal lacerations of the face in children.
(12) I think we are still trying to understand all that and I think that fits under the broader topic of social licence and what bringing in automation to an area does to that region as a whole, which we don’t quite know yet.” Could carbon farming be the answer for a 'clapped-out' Australia?
(13) UPDATE II [Tues.] Two other items that may be of interest: first, Guardian editor-in-chief Alan Rusbridger was the guest for the full hour yesterday on Democracy Now, discussing the paper's role in reporting the NSA stories, and the video and transcript of the interview are here ; second, marking our collaboration on a series of articles about spying on Indians, the Hindu has a long interview with me on a variety of related topics, here .
(14) CNS excitation and seizures, manifestations of organochlorine intoxication, can occur following ingestion or inappropriate application of the 1 per cent topical formulation of lindane used to treat scabies and lice.
(15) A water based 5% benzoyl peroxide gel (Benzac W5) was compared with topical 1% clindamycin phosphate solution (Cleocin T) in the treatment of acne vulgaris using a randomized, investigator blind study design.
(16) In conclusion, this study indicates that topical CsA is capable of locally suppressing a strong T-cell-mediated immune response after an initial short-term systemic dose of CsA.
(17) Poly(ortho ester) bioerodible polymers are suitable materials for the topical administration of a wide variety of therapeutic agents; varying the nature and amounts of excipients physically incorporated into the polymer will vary the erosion rates from a few hours to many months.
(18) Future studies will need to carefully evaluate the vehicle used and the strength of topical CsA employed.
(19) The animal model of psoriasis was effectively treated by bimolane, both systemically and topically, and also by parenteral methotrexate and topical betamethasone valerate.
(20) Data were compared with those from a previous study with topical 1% minoxidil solution.