(n.) The opinion or doctrine that everything in nature, being the work of God, is ordered for the best, or that the ordering of things in the universe is such as to produce the highest good.
(n.) A disposition to take the most hopeful view; -- opposed to pessimism.
Example Sentences:
(1) The optimal size for stimulation was between 5 degrees and 12 degrees (visual angle).
(2) In addition, intravenous injection of complexes into rabbits showed optimal myocardial images with agents of intermediate lipophilicity.
(3) More research and a national policy to provide optimal nutrition for all pregnant women, including the adolescent, are needed.
(4) A beta-adrenergic receptor cDNA cloned into a eukaryotic expression vector reliably induces high levels of beta-adrenergic receptor expression in 2-12% of COS cell colonies transfected with this plasmid after experimental conditions are optimized.
(5) Enhanced sensitivity to ITDs should translate to better-defined azimuthal receptive fields, and therefore may be a step toward achieving an optimal representation of azimuth within the auditory pathway.
(6) T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation.
(7) This optimization resulted in products which are now studied in-vivo.
(8) This promotion of repetitive activity by the introduction of additional potassium channels occurred up to an "optimal" value beyond which a further increase in paranodal potassium permeability narrowed the range of currents with a repetitive response.
(9) In general, optimal DAGAT activity in vitro was observed when long-chain unsaturated acyl-CoAs and diacylglycerols (DAGs) containing long acyl chains were used as substrates for in vitro TAG synthesis (although 1,2-didecanoin was also very effective).
(10) In conclusion, autoimmune thyroiditis in an animal model can be prevented by reducing thyroidal iodine or its metabolism and optimal effects require intervention at the embryonic stage.
(11) Research must continue to determine the optimal regimen that suppresses testosterone activity with the least amount of toxicity.
(12) We present the analysis both formally and in geometric terms and show how it leads to a general algorithm for the optimization of NMR excitation schemes.
(13) The effect of exclusion versus inclusion of the fiducial timing point optimizing routine in the signal averaging program was examined in 21 patients.
(14) The nurse is in an optimal position to plan and deliver a program and determine its effectiveness.
(15) elution patterns of the adducts formed by DBF metabolites with DNA and obtained in vivo at the optimal exposure time of 42-48 h were qualitatively very similar to the patterns obtained in vitro, but their amplitude was quantitatively reduced.
(16) Incubation of the blocked filters with radiolabeled DNA under optimal binding conditions and subsequent autoradiography reveals high-affinity DNA-protein interactions.
(17) A technique is therefore described using 3-D images and reconstruction of high-resolution films, which allows rapid examination of the menisci in optimal planes.
(18) The data of first 1000 first-born, non-malformed, mature (greater than or equal to 2500 g) offspring of participants in the Hungarian "Optimal" Family Planning Programme were evaluated.
(19) Molecular mass of the native enzyme is 560,000 and optimal reaction temperature is 70 degrees C. Km value for ribulose 1,5-bisphosphate is 0.27 mM.
(20) Optimal yields of 7-ketolithocholic acid and 7-ketodeoxycholic acid were obtained after 78 h of incubation.
Pessimism
Definition:
(n.) The opinion or doctrine that everything in nature is ordered for or tends to the worst, or that the world is wholly evil; -- opposed to optimism.
(n.) A disposition to take the least hopeful view of things.
Example Sentences:
(1) Ultimately, the judgments combine to make a particularly peculiar melange: among the plaintiffs there is a mix of economic pessimism and insecure nationalism with a shot of nostalgia for the Deutschmark.
(2) Since doctors are generally accepted as experts on health matters, their apparent undue pessimism about cancer prognosis is unfortunate.
(3) Behind the broad sweep of pessimism, it is worth thinking about how the "eurozone in crisis" story could eventually improve.
(4) Pessimism is my default setting," she told the Daily Telegraph.
(5) There has been widespread pessimism, usually without significant data, about the cloth-covered prosthesis, because of concern of cloth wear, hemolysis and other complications.
(6) The cognitive theories of depression emphasize the role of pessimism about the future in the etiology and maintenance of depression.
(7) Other negative emotions – self-pity, guilt, apathy, pessimism, narcissism – make it a deeply unattractive illness to be around, one that requires unusual levels of understanding and tolerance from family and friends.
(8) But Cameron veered from Libya to adoption, from apprenticeships to gay marriage, and on the economy, from optimism to pessimism.
(9) Indications of brain damage sustained during infancy are not grounds for pessimism on the part of the psychotherapeut.
(10) The pessimism about the psychiatric reform that emerges among some general practitioners seems to have more to do with the slow progress in creating intermediary facilities between hospital and region rather than an a priori opposition to the reform.
(11) To the widespread therapeutic pessimism we oppose various psychotherapeutic techniques for the treatment of non-psychotic compulsive phenomenal; for the manifestations occurring in the course of psychotic illnesses, the appropriate psychotropic drugs will be used in the first place, although they are of limited importance in these types of illness which oppose serious difficulties to all methods of treatment.
(12) In MAS, more than a few patients revealed a high anxiety level concretely, recognized psychosocial problems with loss of desire for treatment pessimism recording their prognosis, in addition to loss of QOL.
(13) One of the patterns of rigidity is an outgrowth of the lifestyle of pessimism, suspicion, self-reliance, self-discipline, determination, and endurance.
(14) The findings are discussed with respect to the mechanisms underlying predictive optimism and pessimism and the possible functions and implications of these predictive biases.
(15) But I don’t share the pessimism of a younger friend and activist who says: “I can’t see us being back in office this side of 2030.
(16) The questionnaire measured various attitudes concerning asthma and was used to identify those respondents reporting high levels of pessimism or stigma in relation to their condition.
(17) A kind of ironic pessimism – planning to fail – is a bit of a cliche in contemporary art.
(18) Among the 14 explanatory variables in the multivariate logistic analysis, family members' and friends' smoking, the place of residence, strenuousness of leisure-time physical activities, number of friends, rebelliousness, intelligence test score, and general pessimism were most strongly associated with the likelihood of being a current smoker.
(19) The climate models are unequivocal in their pessimism for the future.
(20) Compared with findings in manic subjects, the dimensional score for Harm Avoidance was elevated in all affective groups, "worry and pessimism" was elevated in mixed-state subjects, "shyness with strangers" was elevated in depressed and nonaffective subjects, and "attachment" was lower in depressed and nonaffective subjects.