(a.) Pertaining to the origin or beginning; preceding all others; first in order; primitive; primary; pristine; as, the original state of man; the original laws of a country; the original inventor of a process.
(a.) Not copied, imitated, or translated; new; fresh; genuine; as, an original thought; an original process; the original text of Scripture.
(a.) Having the power to suggest new thoughts or combinations of thought; inventive; as, an original genius.
(a.) Before unused or unknown; new; as, a book full of original matter.
(n.) Origin; commencement; source.
(n.) That which precedes all others of its class; archetype; first copy; hence, an original work of art, manuscript, text, and the like, as distinguished from a copy, translation, etc.
(n.) An original thinker or writer; an originator.
(n.) A person of marked eccentricity.
(n.) The natural or wild species from which a domesticated or cultivated variety has been derived; as, the wolf is thought by some to be the original of the dog, the blackthorn the original of the plum.
Example Sentences:
(1) Our results suggest that the peripheral sensitivity to hypoxia declined more than that to CO2, implying a peripheral chemoreceptor origin for hypoxic ventilatory decline.
(2) These immunocytochemical studies clearly demonstrated that cells encountered within the fibrous intimal thickening in the vein graft were inevitably smooth muscle cell in origin.
(3) The nuclear origin of the Ha antigen was confirmed by the speckled nuclear immunofluorescence staining pattern given by purified antibody to Ha obtained from a specific immune precipitate.
(4) The origin of the aorta and pulmonary artery from the right ventricle is a complicated and little studied congenital cardiac malformation.
(5) The origins of aging of higher forms of life, particularly humans, is presented as the consequence of an evolved balance between 4 specific kinds of dysfunction-producing events and 4 kinds of evolved counteracting effects in long-lived forms.
(6) These cells contained organelles characteristic of the maturation stage ameloblast and often extended to the enamel surface, suggesting a possible origin from the ameloblast layer.
(7) We conclude that chloramphenicol resistance encoded by Tn1696 is due to a permeability barrier and hypothesize that the gene from P. aeruginosa may share a common ancestral origin with these genes from other gram-negative organisms.
(8) Typological and archaeological investigations indicate that the church building represents originally the hospital facility for the lay brothers of the monastery, which according to the chronicle of the monastery was built in the beginning of the 14th century.
(9) Plasma NPY correlated better with plasma norepinephrine than with epinephrine, indicating its origin from sympathetic nerve terminals.
(10) Interadjudicator agreement was stronger on 'originality' than on 'aesthetic pleasingness'.
(11) One rare case of blind-ending branch originating in the upper third of the ureter are described.
(12) It is my desperate hope that we close out of town.” In the book, God publishes his own 'It Getteth Better' video and clarifies his original writings on homosexuality: I remember dictating these lines to Moses; and afterward looking up to find him staring at me in wide-eyed astonishment, and saying, "Thou do knowest that when the Israelites read this, they're going to lose their fucking shit, right?"
(13) As the requirements to store and display these images increase, the following questions become important: (a) What methods can be used to ensure that information given to the physician represents the originally acquired data?
(14) The condition is compared to extrahepatic and intrahepatic biliary atresia of man and evidence is presented for regarding this case to be one of extrahepatic origin.
(15) The position of the cyst supports the theory that branchial cysts are congenital in origin.
(16) heterografts of GW-39, a CEA-producing colonic tumor of human origin, was demonstrated in radioimmunoassay using radioiodinated CEA purified from GW-39.
(17) The committee reviewed the history, original intent, current purpose, and effectiveness of meetings held on the unit; when problems were identified, suggestions for change were formulated.
(18) The relative strength of the progressions varies with excitation wavelength and this, together with the absence of a common origin, indicates the existence of two independent emitting states with 0-0' levels separated by either 300 or 1000 cm-1.
(19) Sickle and normal discocytes both showed membrane elasticity with reversion to original cell shape following release of the cell from its aspirated position at the pipette tip.
(20) With respect to family environment, a history of sexual abuse was associated with perceptions that families of origin had less cohesion, more conflict, less emphasis on moral-religious matters, less emphasis on achievement, and less of an orientation towards intellectual, cultural, and recreational pursuits.
Transcript
Definition:
(n.) That which has been transcribed; a writing or composition consisting of the same words as the original; a written copy.
(n.) A copy of any kind; an imitation.
(n.) A written version of what was said orally; as, a transcript of a trial.
Example Sentences:
(1) These lysates are comparable to those of Escherichia coli in transcriptional and translational fidelity and efficiency in response to a given template DNA.
(2) This induction is sensitive to actinomycin D but not to protein synthesis inhibitor puromycin, indicating an effect of estradiol at the transcriptional level, possibly mediated by the estrogen receptor.
(3) The promoters of the adenovirus 2 major late gene, the mouse beta-globin gene, the mouse immunoglobulin VH gene and the LTR of the human T-lymphotropic retrovirus type I were tested for their transcription activities in cell-free extracts of four cell lines; HeLa, CESS (Epstein-Barr virus-transformed human B cell line), MT-1 (HTLV-I-infected human T cell line without viral protein synthesis), and MT-2 (HTLV-I-infected human T cell line producing viral proteins).
(4) Quantitative determinations indicate that the amount of PBG-D mRNA is modulated both by the erythroid nature of the tissue and by cell proliferation, probably at the transcriptional level.
(5) Here we show that this induction of AP-2 mRNA is at the level of transcription and is transient, reaching a peak 48-72 hr after the addition of RA and declining thereafter, even in the continuous presence of RA.
(6) At the fepB operator, a 31 base-pair Fur-protected region was identified, corresponding to positions -19 to +12 with respect to the transcriptional start site.
(7) A strong block to the elongation of nascent RNA transcripts by RNA polymerase II occurs in the 5' part of the mammalian c-fos proto-oncogene.
(8) In the absence of an authentic target for the MASH proteins, we examined their DNA binding and transcriptional regulatory activity by using a binding site (the E box) from the muscle creatine kinase (MCK) gene, a target of MyoD.
(9) Thus, human bronchial epithelial cells can express the IL-8 gene, with expression in response to the inflammatory mediator TNF regulated mainly at the transcriptional level, and with elements within the 5'-flanking region of the gene that are directly or indirectly modulated by the TNF signal.
(10) Nevertheless, this LTR does not govern efficient transcription of adjacent genes in a transient expression assay.
(11) Other DNase I hypersensitive sites located adjacent to the S14 cap site at -65 to -265 base pairs (Hss-1) or upstream at -1.3 kb (Hss-2), -2.1 kb (Hss-3'), -5.3 kb (Hss-4), and -6.2 kb (Hss-5) remained unaffected by changes in S14 gene transcription.
(12) In vitro transcription products were analyzed for their 5' end sequences and their oligonucleotide compositions.
(13) We have investigated interactions between the erythroid transcription factor GATA-1 and factors binding two cis-acting elements commonly linked to GATA sites in erythroid control elements.
(14) Thyroid hormones suppress transcription of the gene for the beta-subunit of thyrotropin (TSH beta).
(15) An sdh-specific transcript of about 3,450 nucleotides was detected in vegetative bacteria.
(16) An attempt was made to elucidate possible participation of low molecular weight nuclear RNA's (LMWN RNA's) in the transcription process.
(17) The relative contributions of transcriptional and posttranscriptional regulation of gene expression to the increase in constitutively expressed cellular proteins were examined in mouse kidneys undergoing compensatory growth following unilateral nephrectomy (UNI-NX).
(18) Reverse transcription of retina mRNA followed by DNA amplification using D4-specific nucleotides demonstrates the presence of D4 mRNA in retina.
(19) These levels are sufficient to maintain normal in vivo rates of mRNA and rRNA synthesis, but the average density of packing of polymerases on DNA is considerably less than the maximum density predicted by Miller and Bakken (1972), suggesting that initiation of polymerases of DNA is a limiting factor in the control of transcription.
(20) In addition, a 2.6-kilobase WHV RNA transcript was found in the majority of the NL tissues.