(n.) The organic basis of bone tissue; the residue after removal of the mineral matters from bone by dilute acid; in embryonic tissue, the substance in which the mineral salts are deposited to form bone; -- called also ostein. Chemically it is the same as collagen.
Example Sentences:
(1) The 'Ossein' implants remained as inert material neither invaded by host cells nor inducing any bone formation.
(2) A study was undertaken in 60 adult rabbits in order to determine the effects of ossein-hydroxyapatite compound on bone healing.
(3) The present study was undertaken, therefore, to examine whether oral administration of ossein-hydroxyapatite compound (OHC) could stimulate new bone growth on aluminium oxide implant surfaces and, if so, whether it was the mineral or organic part of the compound which was responsible.
(4) Study was undertaken to identify polypeptide factors in the commercially available ossein-mineral-compound and to see if they are present in a biologically relevant quantity.
(5) Ossein-hydroxyapatite compound (OHC) is a protein-mineral complex derived from bovine bone.
(6) Treatment with ossein-hydroxyapatite compound, but not the other two active treatments, resulted in significant improvements in the pattern and quality of bone healing, particularly when assessed at 56 or 84 days after induction of the bone defect.
(7) Growth factors IGF-I, IGF-II, and TGF-beta were identified in the ossein-mineral-compound.
(8) The ossein-hydroxyapatite compound (OHC) treatment provided 1.6 g calcium, 0.74 g phosphorus and 1.94 g noncollagen peptides a day.
(9) Ossein was solubilized by the action of alkali and a resulting high-molecular-weight fraction isolated.
(10) This strongly suggests that organic components of ossein-hydroxyapatite compound have osteogenic effects, enhancing the utilization of the mineral intake, and is consistent with previous experimental findings.
(11) In our open randomised study, 9 women on heparin-treatment received daily 6.46 g of the bone preparation OHC (ossein-hydroxyapatite-compound) over a period of 6 months and were compared to 11 women without bone protective treatment.
(12) Bone-forming property of 0.6 M HCl decalcified (a) allogeneic bone matrix preserved in 70% alcohol, (b) allogeneic bone matrix preserved in anaesthetic ether, (c) allogeneic 'Ossein' provided by the Leather Research Institute, Madras, and (d) xenogeneic bone-matrix preserved in alcohol was studied by fitting the implants in surgically created complete circumferential osteo-periosteal gaps in the ulna of rabbits.
(13) One group received ossein-hydroxyapatite compound, 830 mg per day, a second group received bone mineral (ossein-hydroxyapatite compound reduced to ash, to remove organic constituents), 510 mg per day, and a third group received calcium carbonate, 650 mg per day.
(14) Because both supplemented groups received equivalent dosages of calcium and phosphate, the additional stimulation of new bone growth must have been due to the organic part of OHC (ossein).
(15) For the prevention and treatment of glucocorticoid-induced osteoporosis, frequently used drugs today are fluorides, ossein-hydroxy-apatite complexes and, especially in acute glucocorticoid osteoporosis, calcitonin.
(16) These results indicate that ossein-hydroxyapatite compound has a beneficial effect on the process of bone healing but that this effect is lost if the organic components of the compound are destroyed or if pure calcium carbonate treatment is substituted.
(17) It is suggested, therefore, that ossein-hydroxyapatite compound has considerable clinical potential and should be regarded as having specific, sophisticated effects on bone metabolism, rather than as a simple dietary mineral supplement.