(n.) One of the protoplasmic cells which occur in the osteogenetic layer of the periosteum, and from or around which the matrix of the bone is developed; an osteoplast.
Example Sentences:
(1) Blocking the heparin-binding domains of fibronectin inhibited osteoblast attachment by 40-45%, which is complementary to inhibition results previously obtained with the RGDS tetrapeptide.
(2) Human GH did not alter basal cyclic AMP levels in mouse osteoblasts.
(3) The detailed sequence of the expression of osteoblastic genes in situ has not been fully characterized.
(4) The present data indicate the osteoblast as a direct and specific target for ipriflavone and suggest that this compound may share intracellular transducing mechanisms with other antiosteoporotic hormones such as estrogen and calcitonin.
(5) The data suggest that after spaceflight there is a strong and rapid recovery mechanism for osteoblast differentiation that is not suppressed by physiological stress.
(6) The presence of alkaline phosphatase-positive cells forming woven bone in giant cell granulomas suggests that osteoblasts are present in the lesion.
(7) Marked declines in stainable bone-surface aluminum were associated with increases in bone formation rate and osteoblastic osteoid following deferoxamine.
(8) They were formed by budding off from the cytoplasmic projections of the osteoblastic tumor cells.
(9) In order to determine the specific action of cadmium on bone metabolism, the effect of cadmium on alkaline phosphatase activity, a marker enzyme of osteoblasts, was compared with that of other divalent heavy metal ions, i.e., zinc, manganese, lead, copper, nickel and mercury (10 microM each), using cloned osteoblast-like cells, MC3T3-E1.
(10) Osteoblast-like rat calvaria cells release specific insulin-like growth factor (IGF) carrier proteins (CPs).
(11) The osseous component consisted of immature woven bone trabeculae lined by abnormal osteoblasts with a fibroblastlike appearance.
(12) This heterogeneity of the osteoblast and odontoblast population suggests that the composition of the matrix produced by these cells also differs.
(13) ALP activity in PLF was stimulated but that of osteoblasts was inhibited under the hypoxic condition.
(14) WCM stimulated adenylate cyclase in osteoblast like cells, the dose-response curve paralleling that of hPTHrP(1-34).
(15) Sections of mitochondria from prenatal osteoblasts showed an average number of 10 granuales per mitochondrial section, whereas sections of mitochondria of postnatal osteoblasts showed only occasionally 1-2 granules per mitochondrial section.
(16) Zn was found in bone matrix, osteoblasts, osteocytes and hypertrophied chondrocytes.
(17) Gold(III) (Au(III)) up to 0.25 microM increased parathyroid hormone- and prostaglandin E2-sensitive chick osteoblast adenylate cyclase activity without affecting 5'-guanylylimidodiphosphate-stimulated enzyme activity.
(18) Biosynthesis of calcitroic acid has been demonstrated in two target cells of vitamin D, in the kidney and the osteoblastic cell line UMR-106.
(19) Cd-treated cells were well differentiated into osteoblasts morphologically, but the mineralization degree was lower than that of the controls.
(20) A monoclonal antibody (MBP 322), raised against a denatured form of a small collagenous bone protein, reacted strongly with osteoblastic cells but more moderately with alveolar bone.
Osteoid
Definition:
(a.) Resembling bone; bonelike.
Example Sentences:
(1) The fibrous matrix and cartilage formed within the nonunion site transformed to osteoid and bone with increased vascularity.
(2) Osteomalacia is characterized by large osteoid seams and a preserved volume of bone trabeculae.
(3) The radiological and macroscopic features were identical with osteoid osteoma.
(4) Marked declines in stainable bone-surface aluminum were associated with increases in bone formation rate and osteoblastic osteoid following deferoxamine.
(5) A sclerotic border and osteoid seams were noted, two features that seem not to have been previously reported in early lesions.
(6) Trabecular bone volume, osteoid amount, and eroded surfaces were measured.
(7) Calcification initially occurs in maxtrix vesicles (or calcifying globules) which are very numerous between the collagen fibrils of the osteoid tissue, and successively spreads into the surrounding interfibrillar matrix.
(8) The frequencies in the two groups are as follows: In the benign group, osteoma had the highest incidence and then, with decreasing frequencies: osteochondroma, chondroma, synovioma, giant cell tumor, ossifying fibroma, osteoid osteoma, chondromyxoid fibroma.
(9) Fluoride-exposed rats accumulated a significantly larger osteoid volume, suggesting an exacerbation of the osteomalacic lesion, and furthermore, dynamic histomorphometric parameters remained depressed.
(10) Four of eight patients had high or high normal fractional resorption surfaces, fractional formation surfaces, and fractional osteoid volumes.
(11) Since the reaction is inhibited at -20 degrees C, complete infiltration of blocks is achieved within 3 d. Polymerization took place at +4 degrees C. The method provides undecalcified bone sections suitable for histomorphometric analysis of osteoid tissue, tetracycline bone labeling and Tartrate Resistant Acid Phosphatase.
(12) Other cells present in osteoid osteoma besides osteocytes included osteoprogenitor cells resembling Scott type A and B cells and cells in transitional stages of differentiation.
(13) Osteoid osteomas were removed by CT-guided core drill excision of the nidus in 4 patients.
(14) We conclude that in patients with osteomalacia, a condition which is characterized by an increased osteoid accumulation due to a decreased mineralization rate, the increased level of serum osteocalcin reflects the increased osteoid synthesis but not the mineralization defect.
(15) Juxta-articular osteoid osteomas often show an absent or small perifocal osteosclerosis, whereas a laminar periosteal reaction was seen in all own cases.
(16) On the other hand, the augmented BMD of the lumbar spine might reflect the overabundance of partially mineralized osteoid.
(17) The histological study of the tibiae showed decreased mineralization with narrower trabeculae and enlarged osteoid seams; bone resorption at the inner surface was also significantly decreased.
(18) Its role could be limited in the removal of any non-mineralized collagen layers which could be covering mineralized bone surfaces and which seem to prevent the activation of osteoclasts and thus their action; such a "shield" of unmineralized osteoid is well-established at the surface of actively growing woven bone, although not on the resorbing surfaces of mature lamellar bone.
(19) The amount of osteoid and the length of the osteoid seams were normal, whereas the mean width of the osteoid seams was decreased.
(20) Immunohistochemical staining shows that BMP is distributed along collagen fibres in normal bone, also exist in osteoid tissue of new bone, in osteoblasts and in the cells of bone marrow.