(n.) The operation of breaking a bone in order to correct deformity.
Example Sentences:
(1) The modern corticotomy has evolved from the initial open osteotomies, which eventually proved to be traumatic to bone's osteogenic elements, and closed bone osteoclasis, which proved time consuming and difficult to control.
(2) The question of osteoblastic osteoclasis falls into this category.
(3) The distractions were performed after both open osteotomy and closed osteoclasis.
(4) The correction of angular deformities of long bones by incomplete osteotomy, followed three weeks later by manual osteoclasis, overcomes the problem of secondary displacement sometimes seen after correction by complete osteotomy and makes internal fixation unnecessary.
(5) Bone loss may be the direct result of mechanical injury, increased osteoclasis, or direct lysis of bone by various enzymes released by the interface membrane.
(6) Eight years ago, axial correction of deformities of the femora and tibiae by manual osteoclasis was carried out in a 7 year old girl in whom osteogenesis imperfecta had produced severe bowing of the long bones of the legs.
(7) In one case, a 15 degree internal rotation deformity was corrected after 5 weeks by osteoclasis and fresh elastic nailing which also healed.
(8) Ultimately, this led to the combination of an open partial subperiosteal cortical osteotomy, followed by manual osteoclasis of the remainder of the bone cortex.
(9) It is concluded that in metaphyseal bone 1,25-(OH)2D3 increased the number and synthetic activity of osteoblasts without significantly enhancing osteoclasis or osteocytic osteolysis.
(10) These findings were interpreted to suggest that PTH mobilizes bone mineral by osteoclasis and increases metabolic activity of the osteocyte-osteoblast pump.
(11) Increased osteoclasis in uremic rats was limited to diaphyseal cortical bone while metaphyseal trabeculae were relatively unaffected compared to sham-operated rats administered vitamin D. Ultrastructurally thyroid C cells were degranulated and in an active stage in both groups of rats receiving vitamin D. Urinary calcium excretion was greater in sham-operated rats given vitamin D than in uremic rats.
(12) As there was no elevation of the osteoblastic activity in knee joints with developing osteoarthrosis, it would appear that bone sclerosis associated with the disease was due to decreased osteoclasis.
(13) Modes and surgical treatment include osteoclasis and percutaneous pinning for long-bone deformities in the infant and, in the child older than two years of age, segmentation and the use of telescoping rods.
(14) An excess of bone surfaces were covered by osteoid seams, all of which showed active mineralisation, indicating a relative increase in osteoblastic activity; osteoclasis seemed to be unaffected.
(15) In rats given 5 units of 1,25-(OH)2D3, osteoclasis was markedly increased.
(16) Eight of fourteen patients elected some form of surgical revision, most commonly closed osteoclasis with restoration of femoral length, followed by the insertion of a statically locked nail.
(17) The results accord with hypotheses that (1) osteoclasis of scaffoldtype woven bone is impaired in mi mi, (2) that osteoclastic cells are derived through circulating monocytes from hematopoietic stem cells, and (3) in mi mi this defect can be overcome by a transplant of normal hemopoietic stem cells.
Osteoclast
Definition:
(n.) A myeloplax.
(n.) An instrument for performing osteoclasis.
Example Sentences:
(1) A novel staining procedure for enumerating osteoclasts on neonatal mouse calvaria with the vital fluorescent dye acridine orange is described.
(2) Light microscopic autoradiography after labeling of the cultures with tritiated thymidine showed that both RA and 1,25-(OH)2D3 induced osteoclast differentiation from proliferating and postmitotic precursors.
(3) We have previously shown that multinucleated cells (MNC) with many features of the osteoclast phenotype form in long term human marrow cultures.
(4) Osteoclasts dissolve bone mineral by the vectorial secretion of hydrogen ion at their osseous attachment site.
(5) Superoxide dismutase (SOD) inhibited the accumulation of formazan by the isolated osteoclasts.
(6) Addition of extracellular Ca2+ (5 mM CaCl2), a potent osteoclast inhibitor, increased [Ca2+]i in all osteoclasts, but 10(-6) M salmon calcitonin (sCT) did so only in a subpopulation of osteoclasts.
(7) Osteoclasts were isolated from the long bones of neonatal rabbits and cultured on devitalized bovine bone slices for 8, 24, 48 and 72 h with and without prostaglandin E2 (PGE2) (10(-6) M).
(8) Marrow macrophages, at various stages of in vitro maturation, also possess lysozyme mRNA but in amounts approximately two to four times lower than osteoclasts.
(9) The use of diphosphonates (bisphosphonates), a group of potent osteoclast inhibitors, is discussed in some detail.
(10) Dimethylamiloride (100 microM) inhibited bone resorption by 80% and 65% when added at t = 0 or 1 hr after osteoclast adherence, but was without effect when added at t = 3 or 6 hr.
(11) These results provide strong evidence for the osteoclastic nature of the giant cells in this variant of the MFH.
(12) Since the osteoclast plays an important role in the resorption and remodeling of bone in these middle ear diseases, the source, physiology, and local control of these cells are of prime importance in investigating the pathophysiology of these diseases.
(13) The effects of interleukin-1 did not appear to be related to osteoclast precursor proliferation, since hydroxyurea (which inhibits DNA synthesis in these cultures) had no effect on the response of calvaria calavaria increases osteoclast to interleukin-1.
(14) These results indicate that CT activates PKC in osteoclasts and that this activation, like the activation of cAMP-dependent protein kinase, leads to an inhibition of bone resorption.
(15) Quantitative time-lapse videomicroscopy showed that the CT-induced retraction of osteoclasts also involved activation of the PKC pathway and could therefore be induced by phorbol esters.
(16) Thus, the resorption-antagonizing capacities of EHDP, Cl2MDP and APD reflect metabolic inhibition, with selectivity for the osteoclast resulting from high affinity binding to bone mineral.
(17) NBT staining was detected only in osteoclasts in cultures of resorbing bones.
(18) Band 5 represents the only tartrate-resistant form and is present in bone osteoclasts and in human alveolar macrophages (AMs).
(19) These results suggest that osteoclast resorbs bone by secreting protons through vacuolar H(+)-ATPase.
(20) Hypercalcemia in this model is mediated in part by the effects of PTH-rP to increase osteoclastic bone resorption.